77 completed, 19 recruiting, 10 unknown, 8 terminated. 130 Phase 2, 31 Phase 1, 17 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use. Sham Air, Supplemental Oxygen - Sleep-disordered Breathing, Chronic Opioid Use | Phase 2 | Not yet recruiting | University of California, San Diego | 62 | 2026-12-01 | 2026-11-06 |
| A Study Of Synthetic THC And Sleep Dronabinol, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Not yet recruiting | Mayo Clinic | 72 | 2026-11-01 | 2026-09-18 |
| Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea Continuous Positive Airway Pressure, Tirzepatide - Sleep Apnoea, Obesity & Overweight | Phase 2 / Phase 3 | Not yet recruiting | Woolcock Institute of Medical Research | 256 | 2026-10-01 | 2026-11-02 |
| Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition - Obstructive Sleep Apnea, Sleep-disordered Breathing | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 24 | 2026-09-01 | 2026-09-21 |
| The Optimal One-Month Dosing of Lemborexant for Moderate Obstructive Sleep Apnea (OSA) Patients With Low Arousal Threshold Lemborexant 5 MG [Dayvigo] Period 1, Placebo Period 1, Lemborexant 5 MG [Dayvigo] Period 2 - OSA - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Not yet recruiting | Chulalongkorn University | 36 | 2026-09-01 | 2026-07-06 |
| DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea. IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide - Obstructive Sleep Apnea (OSA) | Phase 2 | Recruiting | Incannex Healthcare Ltd | 120 | 2026-07-21 | 2026-11-12 |
| Post-Operative Steroids After Sleep Surgery 8mg dexamethasone - Obstructive Sleep Apnea | Phase 2 | Withdrawn | Medical University of South Carolina | 2026-07-01 | 2026-10-06 | |
| Botulinum Toxin in the Palatopharyngeal Muscle for the Treatment of Obstructive Sleep Apnea BOTULINUM TOXIN IN THE PALATOPHARYGEUS MUSCLE - Sleep Apnea Syndrome, Obstructive, Sleep Apnea Syndrome (OSAS) | Phase 2 | Not yet recruiting | Hospital Felicio Rocho | 20 | 2026-04-05 | 2026-02-10 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping Eszopiclone 3 mg, Placebo, Lemborexant 10mg - OSA - Obstructive Sleep Apnea | Phase 2 | Recruiting | Flinders University | 15 | 2025-10-31 | 2026-09-02 |
| DRonabinol Treatment of OSA Dronabinol - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 120 | 2025-08-25 | 2026-11-05 |
| Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea Sivopixant, Placebo, Acetazolamide - Sleep Apnea | Phase 2 | Active not recruiting | Shionogi | 60 | 2025-04-02 | 2026-05-06 |
| A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension Lorundrostat, Placebo - Obstructive Sleep Apnea, Hypertension | Phase 2 | Completed | Mineralys Therapeutics Inc. | 48 | 2025-02-28 | 2026-08-21 |
| Impact of Exogenous Ketones on Sleep Apnea Ketone-IQ, Placebo - Obstructive Sleep Apnea, Sleep | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2025-01-29 | 2026-09-21 | |
| Study That Tests AD109 in Patients Taking GLP-1 Drugs AD109 - OSA | Phase 2 | Completed | Apnimed | 40 | 2024-05-20 | 2025-02-19 |
| RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA IHL-42X Low Dose, IHL-42X High Dose, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Completed | Incannex Healthcare Ltd | 121 | 2024-05-02 | 2026-07-27 |
| EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION Aprepitant 125 and 80Mg Oral Capsule, Placebo - Apnea, Obstructive | Phase 2 | Recruiting | University Hospital, Rouen | 24 | 2024-03-05 | 2026-05-11 |
| The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome) bi-level positive pressure non invasive ventilation, Oxygen gas - Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease | Phase 2 | Recruiting | University of California, San Diego | 240 | 2024-02-13 | 2026-06-03 |
| Endotypic Traits and Obstructive Sleep Apnea Surgery Acetazolamide 500 MG QHS, Eszopiclone 3 mg QHS - Obstructive Sleep Apnea | Phase 2 | Recruiting | University of California, Los Angeles | 150 | 2024-01-07 | 2026-07-01 |
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Sleep Apnea Syndromes (30) · Hypertension (8) · Obesity (7) · Sleep Wake Disorders (6) · Apnea (5) · Sleep Apnea, Central (4) · Stroke (4) · Disorders of Excessive Somnolence (3) · Down Syndrome (3) · Obesity Hypoventilation Syndrome (3) · Pain (3) · Pulmonary Disease, Chronic Obstructive (3) · Cardiovascular Diseases (2) · Chronic Pain (2)
Dyssomnias (130) · Nervous System Diseases (130) · Respiratory Tract Diseases (130) · Sleep Disorders, Intrinsic (130) · Respiration Disorders (128) · Apnea (125) · Sleep Wake Disorders (124) · Sleep Apnea Syndromes (100) · Pathological Conditions, Signs and Symptoms (27) · Signs and Symptoms (21) · Nutritional and Metabolic Diseases (13) · Neurologic Manifestations (12) · Vascular Diseases (11) · Cardiovascular Diseases (10) · Mental Disorders (10)
Continuous Positive Airway Pressure (13) · Acetazolamide (11) · Atomoxetine Hydrochloride (11) · Eszopiclone (7) · Dronabinol (5) · Oxygen (4) · oxybutynin (4) · Occlusal Splints (3) · Sugars (3) · Tablets (3) · lemborexant (3) · Desipramine (2) · Dexmedetomidine (2) · Trazodone (2) · (Lys-Gly)(5)cyclo(75-82)MBP(74-85) (1)
Brigham and Women's Hospital (21) · Apnimed (10) · University of California, San Diego (9) · Johns Hopkins University (4) · VA Office of Research and Development (4) · Bayer (3) · Flinders University (3) · University of Michigan (3) · Apnex Medical, Inc. (2) · Chulalongkorn University (2) · Duke University (2) · George Washington University (2) · Göteborg University (2) · Incannex Healthcare Ltd (2) · Istituto Auxologico Italiano (2)
United States (85) · Australia (7) · France (6) · Italy (4) · Switzerland (4) · Canada (3) · United Kingdom (3) · Denmark (2) · Germany (2) · Sweden (2) · Thailand (2) · Belgium (1) · Brazil (1) · China (1) · India (1)
Atul Malhotra, MD (3) · Jeremy Orr, MD (3) · Scott A Sands, PhD (3) · Christopher N Schmickl, MD, PhD (2) · Christopher Schmickl, MD, PhD (2) · Elisa Perger, MD (2) · Jan Hedner, MD. Prof. (2) · Ron Farkas, MD (2) · Sarocha Vivatvakin, MD (2) · Alan R Schwartz, M.D. (1) · Andrew Wellman, MD PhD (1) · Andrew Wellman, MD, PhD (1) · Anthony Doufas (1) · Aristidis Veves, MD (1) · Barbara J Morgan, PhD, PT (1)
PMID 17294232, PMID 18513353, PMID 18711110, PMID 19393404, PMID 20086074, PMID 21557231, PMID 21614467, PMID 21784661, PMID 21885958, PMID 22043118, PMID 22131599, PMID 22334806, PMID 22547887, PMID 22572632, PMID 22893765, PMID 22968110, PMID 23086863, PMID 23920422, PMID 24041858, PMID 24458967, PMID 24815497, PMID 24918372, PMID 25136550, PMID 25221387, PMID 25805361, PMID 25892349, PMID 26567858, PMID 26643404, PMID 26967681, PMID 27092703, PMID 28364504, PMID 28387543, PMID 29035093, PMID 29121334, PMID 29510792, PMID 29750475, PMID 29800466, PMID 30395486, PMID 31922899, PMID 32649638, PMID 32862007, PMID 33491327, PMID 34225174, PMID 34531274, PMID 34543665, PMID 35551600, PMID 35947827, PMID 35975547, PMID 36435266, PMID 36494591
K23HL151880 (2), 2009 (1), 2015 (1), 2017 (1), 2019 (1), I01CX002632 (1), K23HL153897 (1), K23HL161336 (1), P30DK072476 (1), R01HL065176 (1), R01HL106410 (1), R01HL128658 (1), R01HL160993 (1), R01HL179220 (1), R01NS042698 (1)