62 completed, 5 recruiting, 3 terminated, 1 unknown. 25 Phase 4, 16 Phase 3, 12 Not applicable, 10 Phase 2, 8 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea Eszopiclone, Placebo - Sleep Apnea, Obstructive Sleep Apnea | Phase 3 | Recruiting | Yale University | 250 | 2026-05-18 | 2026-06-03 |
| Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping Eszopiclone 3 mg, Placebo, Lemborexant 10mg - OSA - Obstructive Sleep Apnea | Phase 2 | Recruiting | Flinders University | 15 | 2025-10-31 | 2026-09-02 |
| Impact of Eszopiclone on Blood Pressure in Patients With Insomnia and Hypertension (PRYSMA-HTN) Eszopiclone 3 mg, Placebo - Insomnia, Hypertension | Phase 4 | Recruiting | University of Sao Paulo | 150 | 2025-06-04 | 2025-06-12 |
| Endotypic Traits and Obstructive Sleep Apnea Surgery Acetazolamide 500 MG QHS, Eszopiclone 3 mg QHS - Obstructive Sleep Apnea | Phase 2 | Recruiting | University of California, Los Angeles | 150 | 2024-01-07 | 2026-07-01 |
| Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP) Eszopiclone 2 mg, Placebo - Obstructive Sleep Apnea | Phase 2 | Completed | University of California, San Diego | 42 | 2023-08-31 | 2025-11-25 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
| Rescue Pharmacotherapy for OSA Placebo, Acetazolamide, Trazodone - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 70 | 2023-07-01 | 2026-07-15 |
| Bioavailability of Eszopiclone 3.0 mg With Regards to Reference Product Eszopiclone 3mg Test Drug T-1 Coated Tablets, Eszopiclone 3mg Test Drug T-2 Coated Tablets, Eszopiclone 3mg Reference Product Coated Tablets - Bioequivalence | Phase 1 | Completed | Laboratorios Andromaco S.A. | 28 | 2022-04-11 | 2022-04-27 |
| National Adaptive Trial for PTSD Related Insomnia Trazodone, Eszopiclone, Placebo - Insomnia | Phase 3 | Completed | VA Office of Research and Development | 673 | 2021-02-25 | 2026-06-03 |
| Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea Acetazolamide, Eszopiclone, Placebo - OSA, Obstructive Sleep Apnea | Phase 2 | Completed | University of California, San Diego | 20 | 2020-12-01 | 2024-05-29 |
| Modified Suanzaoren Decoction Versus Eszopiclone for the Treatment of Chronic Insomnia Disorder suanzaoren decoction, Eszopiclone 1 mg - Chronic Insomnia Disorder | Not applicable | Completed | Central South University | 85 | 2020-09-10 | 2024-06-11 |
| Do Endotypes Predict Response and Sequelae in OSA Patients Eszopiclone, Supplemental Oxygen, Continuous Positive Airway Pressure (CPAP) - Obstructive Sleep Apnea, Sleep Apnea | Phase 2 | Completed | University of California, San Diego | 233 | 2020-08-01 | 2026-06-18 |
| Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD eszopiclone, Brief behavioral therapy for insomnia - Complex Insomnia | Phase 4 | Completed | VA Office of Research and Development | 53 | 2019-12-01 | 2025-10-21 |
| Safety and Efficacy of Chronic Hypnotic Use 2 placebo, Zolpidem CR, Eszopiclone - Chronic Insomnia | Phase 4 | Completed | Henry Ford Health System | 41 | 2015-08-05 | 2024-03-29 |
| Auricular Acupuncture for Primary Insomnia auricular acupuncture(AA), placebo AA, Eszopiclone - Primary Insomnia | Not applicable | Completed | Chengdu University of Traditional Chinese Medicine | 288 | 2014-03-01 | 2020-02-17 |
| Investigation of the Safety and Efficacy of Eszopiclone in Insomnia Patients Eszopiclone - Insomnia | Completed | Eisai Co., Ltd. | 4876 | 2012-10-01 | 2018-09-07 | |
| Investigation of the Safety and Efficacy of Long Term Administration of Eszopiclone in Insomnia Patients Eszopiclone - Insomnia | Completed | Eisai Co., Ltd. | 438 | 2012-10-01 | 2018-09-07 | |
| Sleep Effectiveness and Insulin and Glucose Homeostasis eszopiclone - Diabetes, Prediabetic | Phase 1 | Terminated | Beth Israel Deaconess Medical Center | 20 | 2012-10-01 | 2019-12-19 |
| Combination Therapy to Treat Sleep Apnea Placebo pill, Sedative, Room air - Sleep Apnea, Obstructive | Not applicable | Completed | Brigham and Women's Hospital | 22 | 2012-08-01 | 2017-03-03 |
| Effects of Eszopiclone on Sleep and Memory in Schizophrenia eszopiclone, placebo - Schizophrenia | Not applicable | Completed | Massachusetts General Hospital | 59 | 2012-07-01 | 2017-06-14 |
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Sleep Initiation and Maintenance Disorders (45) · Sleep Apnea, Obstructive (14) · Anxiety Disorders (5) · Depression (4) · Depressive Disorder, Major (4) · Pain (3) · Schizophrenia (3) · Sleep Apnea Syndromes (3) · Sleep Wake Disorders (3) · Stress Disorders, Post-Traumatic (3) · Attention Deficit Disorder with Hyperactivity (2) · Fatigue (2) · Generalized Anxiety Disorder (2) · Insulin Resistance (2) · Parasomnias (2)
Sumitomo Pharma America, Inc. (14) · Brigham and Women's Hospital (5) · Eisai Co., Ltd. (5) · University of California, San Diego (5) · Massachusetts General Hospital (4) · Yale University (3) · Dr. Reddy's Laboratories Limited (2) · Johns Hopkins University (2) · University of California, Los Angeles (2) · VA Office of Research and Development (2) · Walter Reed Army Medical Center (2) · Beth Israel Deaconess Medical Center (1) · Butler Hospital (1) · Central South University (1) · Chengdu University of Traditional Chinese Medicine (1)
United States (52) · Japan (5) · Brazil (3) · India (3) · United Kingdom (3) · China (2) · Australia (1) · Austria (1) · Croatia (1) · France (1) · Hungary (1) · Poland (1) · Romania (1) · Russia (1) · Serbia (1)
Akira Endo (2) · Atsushi Kamijo (2) · Atul Malhotra, MD (2) · Christopher J Lettieri, MD (2) · Dr. Ronak Modi, MBBS (2) · Ali A El-Solh, MD MPH (1) · Andrea H. Weinberger, Ph.D. (1) · Andrew D Krystal, MD (1) · Audrey Zinchuk,, MD, MHS (1) · Catherine S. Sassoon, MD (1) · Cenk Tek, M.D. (1) · Christopher N Schmickl, MD, PhD (1) · Christopher Schmickl (1)
PMID 21208574, PMID 25266438, PMID 17138773, PMID 18458207, PMID 18788656, PMID 19567493, PMID 19920270, PMID 20098520, PMID 20175406, PMID 20478741, PMID 20571180, PMID 20726279, PMID 21116652, PMID 21269278, PMID 21296508, PMID 21359104, PMID 21367352, PMID 21397868, PMID 21447050, PMID 21601519, PMID 22334811, PMID 22731653, PMID 23063301, PMID 24882900, PMID 24951039, PMID 25323219, PMID 26488677, PMID 26872077, PMID 27634790, PMID 28409851, PMID 34416369, PMID 39514000, PMID 40202618, PMID 40384005, PMID 40778328, PMID 42157543
M01RR002635 (1), P01HL095491 (1), R01HL102321 (1), R01HL160993 (1), R01HL179077 (1), R21DA025794 (1), R34MH070821 (1), R34MH091338 (1)