246 completed, 73 recruiting, 46 unknown, 23 terminated. 217 Not applicable, 39 Phase 2, 17 Phase 3, 16 Phase 1, 6 Phase 4.
Follow Down Syndrome: new trials by email Literature Review of Down Syndrome trials Research Report on Down Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA - Obstructive Sleep Apnea, Down Syndrome (Trisomy 21) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 50 | 2026-11-02 | 2026-10-07 |
| Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance EMPOWER-ND - Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD) | Not applicable | Not yet recruiting | Boston University Charles River Campus | 50 | 2026-11-01 | 2026-10-27 |
| Escalating Doses of Memantine in Down Syndrome (MEDS-123) Memantine - Down Syndrome, Intellectual Disability | Phase 1 | Not yet recruiting | University Hospitals Cleveland Medical Center | 25 | 2026-10-14 | 2026-10-05 |
| An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression Disorder Ublituximab - Down Syndrome Regression Disorder (DSRD), Down Syndrome (Trisomy 21) | Phase 2 | Not yet recruiting | Jonathan Santoro | 20 | 2026-10-01 | 2026-09-23 |
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-09-02 | 2026-09-10 | |
| Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down Syndrome Vestibular Stimulation Exercises, Foot Intrinsic Muscle Exercises - Down Syndrome, Balance Impairment | Not applicable | Not yet recruiting | Shalamar Institute of Health Sciences | 48 | 2026-09-02 | 2026-08-21 |
| Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment Syntactic-Semantic Visual Configuration Intervention (SSVCI) - Language Impairment, Autism | Not applicable | Not yet recruiting | Riphah International University | 20 | 2026-09-01 | 2026-08-26 |
| Executive Function Play Opportunities for Children With Down Syndrome EXPO, EXPO Extended, EXPO Foundations - Down Syndrome, Trisomy 21 | Not applicable | Not yet recruiting | Colorado State University | 150 | 2026-09-01 | 2026-08-28 |
| Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome suspension walker - Down Syndrome | Not applicable | Not yet recruiting | University of Southern California | 12 | 2026-09-01 | 2026-06-05 |
| NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome MIB-626, Placebo - Down Syndrome (DS) | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 24 | 2026-08-31 | 2026-08-19 |
| A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD) Mivelsiran, Placebo - Down Syndrome-Associated Alzheimer's Disease (DS-AD) | Phase 2 | Recruiting | Alnylam Pharmaceuticals | 58 | 2026-08-17 | 2026-10-13 |
| Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation Donanemab, Placebo - Down Syndrome (DS), Down Syndrome (Trisomy 21) | Phase 4 | Not yet recruiting | Michael Rafii, MD, PhD | 60 | 2026-08-01 | 2026-05-15 |
| The Neurocognitive Bases of Trust in Intellectual Disability Confidence adjustment assessment, clinical assessment, Cognitive assessment - Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS) | Recruiting | Hospices Civils de Lyon | 112 | 2026-07-17 | 2026-08-05 | |
| Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome Metric-optimized spectacles, Routine Clinical Spectacles - Refractive Error Correction, Visual Acuity | Phase 2 | Recruiting | Ohio State University | 24 | 2026-07-13 | 2026-07-20 |
| Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy Down Syndrome | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 700 | 2026-06-23 | 2026-10-19 | |
| Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1 Tofacitinib Oral Solution, Placebo - Down Syndrome | Phase 2 | Recruiting | University of Colorado, Denver | 92 | 2026-05-28 | 2026-09-03 |
| Collaboration for Down Syndrome Progress (CDP) Down Syndrome, Chromosome Disorders | Recruiting | RTI International | 1400 | 2026-05-01 | 2026-06-04 | |
| HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome The HomeGrown, Waitlist - Down Syndrome, Child Obesity | Not applicable | Active not recruiting | UNC Lineberger Comprehensive Cancer Center | 38 | 2026-04-16 | 2026-09-03 |
| Vascular Function in Adults With Down Syndrome Down Syndrome (Trisomy 21) | Recruiting | University of Nevada, Las Vegas | 46 | 2026-04-09 | 2026-10-02 | |
| Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia - Down Syndrome, Autonomic Dysfunction | Phase 3 | Recruiting | University of Colorado, Denver | 200 | 2026-04-06 | 2026-10-13 |
Showing 20 of 433. Sign in to see all of them.
Alzheimer Disease (30) · Sleep Apnea, Obstructive (27) · Trisomy 18 Syndrome (27) · Trisomy 13 Syndrome (24) · Intellectual Disability (19) · Cerebral Palsy (18) · Motor Activity (16) · Aneuploidy (15) · Autism Spectrum Disorder (14) · Turner Syndrome (14) · Cognitive Dysfunction (12) · Developmental Disabilities (10) · Fragile X Syndrome (9) · Autistic Disorder (8)
Abnormalities, Multiple (433) · Neurobehavioral Manifestations (433) · Congenital Abnormalities (432) · Neurologic Manifestations (432) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (431) · Genetic Diseases, Inborn (431) · Nervous System Diseases (431) · Chromosome Disorders (430) · Intellectual Disability (414) · Pathological Conditions, Signs and Symptoms (88) · Mental Disorders (85) · Signs and Symptoms (56) · Central Nervous System Diseases (54) · Brain Diseases (51) · Behavior (44)
Blood Specimen Collection (6) · Cytarabine (6) · Exercise (5) · Leucovorin (5) · Control Groups (4) · Dexamethasone (4) · Donepezil (4) · Memantine (4) · Mercaptopurine (4) · Methotrexate (4) · Polysomnography (4) · Vincristine (4) · Asparaginase (3) · Atomoxetine Hydrochloride (3) · Calcium Dobesilate (3)
Riphah International University (48) · Cairo University (12) · University of Colorado, Denver (12) · Institut Jerome Lejeune (10) · Natera, Inc. (8) · Sequenom, Inc. (8) · University of Kansas Medical Center (8) · University of Sao Paulo (8) · Children's Hospital Medical Center, Cincinnati (7) · Hoffmann-La Roche (7) · Oregon Health and Science University (5) · Parc de Salut Mar (5) · University of Michigan (5) · Assistance Publique - Hôpitaux de Paris (4) · Children's Hospital of Philadelphia (4)
United States (201) · Pakistan (50) · France (39) · Spain (36) · Canada (22) · Egypt (21) · Turkey (Türkiye) (19) · United Kingdom (15) · Italy (14) · Australia (8) · Brazil (8) · Ireland (8) · Saudi Arabia (6) · Belgium (5) · Mexico (5)
Joaquin Espinosa, PhD (4) · Michael S. Rafii, MD, PhD (3) · Richard Porreco, MD (3) · Suelly CO Limongi, PhD (3) · Alberto C Costa, MD, PhD (2) · Amy Bodde, PhD (2) · Amy J Sehnert, MD (2) · Andrea Kelly, MD, MSCE (2) · Anna Esbensen, PhD (2) · Binash Afzal, PHD* (2) · Brian Chicoine, MD (2) · Daniel Combs, MD (2) · Glenn E Palomaki, PhD (2) · Michael Rafii, MD, PhD (2)
PMID 22005709, PMID 22281937, PMID 25834952, PMID 10417280, PMID 10586155, PMID 12820840, PMID 12889762, PMID 16814942, PMID 17344250, PMID 18296460, PMID 19104360, PMID 20075148, PMID 20084109, PMID 20097432, PMID 20375405, PMID 20673078, PMID 20927000, PMID 21310373, PMID 21352207, PMID 21519036, PMID 21829931, PMID 21950393, PMID 22247403, PMID 22362253, PMID 22464072, PMID 22585317, PMID 22617594, PMID 22742782, PMID 22806212, PMID 22940168, PMID 23072851, PMID 23215555, PMID 23521658, PMID 23555282, PMID 23592541, PMID 23592550, PMID 23613152, PMID 23635743, PMID 23712453, PMID 23968742, PMID 24091801, PMID 24135152, PMID 24360805, PMID 24388429, PMID 24408338, PMID 24571752, PMID 24785862, PMID 24831720, PMID 25004354, PMID 25111587
U10CA180886 (4), 2023 (2), 2025 (2), R01AG016381 (2), R01HD071981 (2), R61HL151253 (2), 3KL2TR002367-08S1 (1), 5TL1TR002318-07 (1), K12HD055931 (1), K23MH077554 (1), K99HD092606 (1), KL2TR002367 (1), OT2HD117033 (1), R00HD092606 (1), R01AG031110 (1)