15 completed, 1 enrolling by invitation, 1 unknown. 13 Phase 2, 4 Phase 3, 2 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 13 |
| Phase 3 | 4 | Completed 3, Enrolling by invitation 1 |
| Phase 1 | 2 | Completed 2 |
| Not applicable | 1 | Unknown 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes STANDARDCARE (STAND) group, CONTROL (CON) group - Obstructive Sleep Apnea | Not applicable | Unknown | Coastal Carolina University | 60 | 2024-08-30 | 2024-12-09 |
| Continuation Protocol for Obstructive Sleep Apnea (OSA) Aroxybutynin and Atomoxetine - OSA | Phase 3 | Enrolling by invitation | Apnimed | 1280 | 2024-07-03 | 2025-05-13 |
| Study That Tests AD109 in Patients Taking GLP-1 Drugs AD109 - OSA | Phase 2 | Completed | Apnimed | 40 | 2024-05-20 | 2025-02-19 |
| Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study) AD109, Placebo - OSA | Phase 3 | Completed | Apnimed | 646 | 2023-09-16 | 2026-09-11 |
| Parallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo) AD109, Placebo - OSA | Phase 3 | Completed | Apnimed | 660 | 2023-08-28 | 2025-11-21 |
| AD816 Crossover Study Period A, Period B, Period C - OSA, Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 25 | 2023-04-28 | 2023-11-15 |
| Parallel Arm Trial of AD109 and AD504 In Patients With OSA AD109, AD504, Atomoxetine Hydrochloride - OSA - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 294 | 2021-11-29 | 2026-08-12 |
| Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) Dosing 1: Atomoxetine, AD313 - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Completed | Apnimed | 15 | 2021-10-19 | 2023-04-07 |
| Trial of AD113 and Atomoxetine in OSA Patients With Hypertension AD113, Atomoxetine - Obstructive Sleep Apnea, Hypertension | Phase 2 | Completed | Apnimed | 21 | 2021-07-31 | 2023-08-21 |
| AD109 Dose Finding in Mild to Moderate OSA AD109 dose1- A, AD109 dose2- B, Placebo- C - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 32 | 2020-12-22 | 2022-12-22 |
| Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing AD036, Placebo - Sleep Disordered Breathing | Phase 2 | Completed | Brigham and Women's Hospital | 53 | 2020-12-02 | 2022-03-02 |
| Crossover Trial of AD182 and AD504 in Obstructive Sleep Apnea AD182, AD504, Placebo - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 15 | 2020-12-01 | 2022-09-02 |
| Crossover Trial of AD109 in Obstructive Sleep Apnea AD109, Atomoxetine, R-oxybutynin - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 60 | 2020-10-27 | 2023-01-31 |
| Effect of AD128 to Treat Obstructive Sleep Apnea AD128, Mannitol - Sleep Apnea, Obstructive | Phase 2 / Phase 3 | Completed | Raphael Heinzer | 15 | 2020-10-20 | 2021-08-06 |
| Crossover Trial of AD036 in Obstructive Sleep Apnea AD036, Atomoxetine, Placebo - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 62 | 2020-07-15 | 2023-09-14 |
| Trial of AD036 in Obstructive Sleep Apnea AD036 Dose 1, AD036 Dose 2, AD036 Dose 3 - Obstructive Sleep Apnea | Phase 2 | Completed | Apnimed | 140 | 2019-03-07 | 2023-01-17 |
| Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea SAS0421a, SAS0421b, SAS0421c - Sleep Apnea | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 23 | 2019-01-14 | 2022-03-02 |
Sleep Apnea, Obstructive (15) · Sleep Apnea Syndromes (3) · Hypertension (1) · Sleepiness (1) · Snoring (1)
Atomoxetine Hydrochloride (6) · (Lys-Gly)(5)cyclo(75-82)MBP(74-85) (1) · Mannitol (1) · Polysomnography (1) · Population Groups (1)
United States (16) · Australia (2) · Canada (2) · Switzerland (1)
Ron Farkas, MD (3) · Bradley A Edwards, PhD (2) · Scott A Sands, PhD (2) · Bruce Corser, MD (1) · Raphael Heinzer, MD (1) · Ron Farkas, MD, PhD (1) · Ronald Farkas, MD (1)
PMID 39688178, PMID 35551600, PMID 35975547, PMID 36734173, PMID 36805833, PMID 36861433, PMID 37812772, PMID 38286618, PMID 39305436, PMID 40360261, PMID 42148495