49 completed, 21 unknown, 13 recruiting, 5 not yet recruiting. 65 Not applicable, 7 Phase 4, 6 Phase 2, 6 Phase 3, 2 Phase 1.
Follow Occlusal Splints: new trials by email Literature Review of Occlusal Splints trials Research Report on Occlusal Splints
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders Low-Level Laser Acupuncture, Proprioceptive Training, Stabilization Splint Treatment - Temporomandibular Disorders (TMD), TMJ Disorder | Not applicable | Recruiting | En Chu Kong Hospital | 180 | 2026-10-09 | 2026-10-13 |
| A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin - Obstructive Sleep Apnea (OSA) | Phase 4 | Recruiting | Sairam Parthasarathy | 2400 | 2026-09-04 | 2026-10-19 |
| Mandibular Advancement Device (MAD) and Continuous Positive Airway Pressure (CPAP) for Treatment of Adult Patients Diagnosed With Moderate Obstructive Sleep Apnea Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP) - Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | University of Copenhagen | 70 | 2026-08-01 | 2026-06-30 |
| Prospective Evaluation of New Metrics to Assess Cardiovascular Remodeling in Obstructive Sleep Apnea Continuous positive airway pressure, Mandibular advancement device, Hypoglossal nerve stimulation - Obstructive Sleep Apnea, Cardiovascular (CV) Risk | Recruiting | University Hospital, Antwerp | 270 | 2026-06-10 | 2026-06-29 | |
| Ultrasonographic Assessment of Muscle Echogenicity in Myofascial Pain occlusal splint, Lidocaine Hydrochloride 2% Injection Solution - Myofascial Pain | Not applicable | Completed | Istanbul Medipol University Hospital | 80 | 2026-05-16 | 2026-08-11 |
| Mandibular Advancement to Reduce Ventricular Load and Improve Quality-of-life in Heart Failure Mandibular advancement device, Mandibular advancement device (Sham) - Heart Failure, OSA - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | National University Hospital, Singapore | 328 | 2026-05-01 | 2026-03-10 |
| Effect of Night Guard Use on Masseter Muscle Thickness in Children With Bruxism Occlusal Splint (Night Guard) - Bruxism, Bruxism, Sleep-Related | Not applicable | Recruiting | Nigde Omer Halisdemir University | 20 | 2026-03-15 | 2026-04-29 |
| Occlusal Splint Combined With Granisetron Injection for Management of Myofascial Pain Related to Temporomandibular Disorders Granisetron, lidocaine, occlusal splint - TMD, TMD/Orofacial Pain | Phase 4 | Active not recruiting | Mansoura University | 48 | 2026-01-27 | 2026-03-05 |
| 3D-Printed vs Conventional Acrylic Stabilization Splints in Young Adults With Bruxism and Temporomandibular Disorders: A Randomized Trial 3D-Printed Occlusal Splint (Voco V-Print), Conventional Acrylic Occlusal Splint - Bruxism, Sleep | Not applicable | Recruiting | Baskent University | 44 | 2026-01-12 | 2026-02-25 |
| Home-based Under Mattress Monitor for OSA Under-mattress monitor, level 3 Home Sleep Apnea Test, Mandibular Advancement Device (MAD) - Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS) | Not applicable | Recruiting | Isabel Moreno Hay | 70 | 2026-01-07 | 2026-02-03 |
| Effect of an Occlusal Splint in Swimming Performance occlusal splint - the Aim of This Study Was to Evaluate the Effect of a Custom Occlusal Splint on Swimming Performance, Stroke Efficiency, and Heart Rate in Master Swimmers, Athletic Performance and the Impact on Performance Factors | Not applicable | Completed | Universidad Europea de Valencia | 20 | 2025-12-01 | 2026-07-13 |
| Postural Perturbations Tracing to the Stomatognathic System Dental splints, Dentures - Posture | Not applicable | Recruiting | Boston University | 40 | 2025-11-17 | 2025-12-04 |
| EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck Muscles Botulinum toxin injection, Occlusal splint, Botulinum toxin + Occlusal splint combined - Myofascial Pain Syndrome (MPS), Masticatory Muscle Pain | Phase 4 | Recruiting | Istanbul University | 56 | 2025-09-01 | 2025-07-24 |
| ePROPP - eHealth for Preventing and Reducing Orofacial Pain in the Population Mobistudy Application, Occlusal splint - Temporomandibular Joint Disorder, Temporomandibular Disorders (TMDs) | Not applicable | Not yet recruiting | Malmö University | 120 | 2025-08-22 | 2025-08-05 |
| Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea Mandibular Advancement Device, Lower Oral Device Without Mandibular Advancement - Gastroesophageal Reflux Disease | Phase 3 | Not yet recruiting | Tuiuti University of Paraná | 40 | 2025-08-01 | 2025-07-08 |
| Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement Mandibular advancement device (MAD) - Obstructive Sleep Apnea | Not applicable | Recruiting | Washington University School of Medicine | 30 | 2025-07-29 | 2026-03-19 |
| Occlusal Splint and Exercise Therapy for Temporomandibular Disorders Occlusal Splint, Exercise - Temporomandibular Disorders (TMD) | Not applicable | Recruiting | Acibadem University | 38 | 2025-07-10 | 2026-04-02 |
| Superimposition of Intra-oral Scans in MAD Therapy for OSA Mandibular Advancement Device - Obstructive Sleep Apnea | Not yet recruiting | Amsterdam UMC, location VUmc | 250 | 2025-07-01 | 2025-07-10 | |
| Low-Level Laser Therapy Versus Occlusal Splint Therapy for Bruxism in Children Low-Level Laser Therapy (LLLT), Occlusal Splint - Bruxism, Sleep Bruxism | Not applicable | Completed | Ain Shams University | 30 | 2025-05-01 | 2026-10-16 |
| Exploring the Relationship Between Occlusion and Degenerative TMJ Disorders: A Comparative Clinical Study Occlusal Splint and Bite Correction Therapy, Conventional TMJ Therapy, Routine TMJ Care (Medication Only) - Degenerative Joint Disease, TMD | Not applicable | Completed | King Khalid University | 150 | 2025-01-10 | 2025-05-07 |
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Sleep Apnea, Obstructive (36) · Temporomandibular Joint Disorders (23) · Bruxism (10) · Sleep Apnea Syndromes (10) · Facial Pain (7) · Sleep Bruxism (7) · Myalgia (4) · Heart Failure (2) · Hypertension (2) · Pain (2) · Sleep Deprivation (2) · Agnosia (1) · Apnea (1) · Bites and Stings (1) · Breast Feeding (1)
Istanbul University (6) · University Hospital, Antwerp (6) · University of Nove de Julho (3) · Academic Centre for Dentistry in Amsterdam (2) · Ain Shams University (2) · Ankara University (2) · Egas Moniz - Cooperativa de Ensino Superior, CRL (2) · Malmö University (2) · National University of Singapore (2) · Université de Montréal (2) · Acibadem University (1) · Amsterdam UMC, location VUmc (1) · Angela Bianco (1) · Associação Fundo de Incentivo à Pesquisa (1) · Baskent University (1)
Turkey (Türkiye) (12) · United States (11) · Brazil (9) · Belgium (8) · Canada (6) · Egypt (5) · France (4) · Netherlands (4) · Singapore (4) · Portugal (3) · Croatia (2) · Denmark (2) · Taiwan (2) · Argentina (1) · Australia (1)
Nelly Huynh, PhD (2) · Alexandros Tsouknidas, PhD (1) · Allan Pack, MD (1) · Angela Bianco, MD (1) · Anne E Sanders, PhD (1) · Bilge Gokcen Rohlig, Prof. Dr. (1) · Bradley A Edwards, PhD (1) · Bruno M Sousa (1) · Carlos F Mir, DSc (1) · Chi-Hang Lee, MD (1) · Ching-Hsia Hung, PhD (1) · Ching-Mao Chang, MD, PhD (1) · Ching-Po Lin, PhD (1)
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R01HL128658 (1)