50 completed, 11 unknown, 10 terminated, 9 recruiting. 38 Not applicable, 9 Phase 4, 6 Phase 2, 4 Phase 3, 1 Phase 1.
Follow Sleep Apnea, Central: new trials by email Literature Review of Sleep Apnea, Central trials Research Report on Sleep Apnea, Central
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea Sleep Apnea Syndrome (OSAS), Central Sleep Apnea | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2026-12-01 | 2026-05-19 | |
| PAH-SDB: Sleep-Disordered Breathing and Outcomes in Pulmonary Arterial Hypertension Standardized Overnight Sleep and Cardiorespiratory Monitoring - Pulmonary Arterial Hypertension (PAH), Sleep-disordered Breathing (SDB) | Recruiting | Chinese Pulmonary Vascular Disease Research Group | 1500 | 2026-10-01 | 2026-10-01 | |
| Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-09-16 | 2026-10-13 |
| Automated Apnoea Detection in Preterms on Non-invasive Ventilation Diaphragmatic electromyography - Apnoea, Prematurity | Not yet recruiting | King's College Hospital NHS Trust | 30 | 2026-09-07 | 2026-08-31 | |
| Development of a Torso Patch Sensor (C-TraQ) as a Companion Device to a Fingertip Sensor (TipTraQ) for Direct Monitoring of Respiratory Effort Sleep Apnea, Obstructives, Sleep Apnea Central | Recruiting | PranaQ Pte. Ltd. | 180 | 2026-06-05 | 2026-08-04 | |
| Locus Coeruleus and CCHS (Congenital Central Hypoventilation Syndrome) MRI, EEG, Pupillometry - Ondine Syndrome (Congenital Central Hypoventilation Syndrome) | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 25 | 2025-10-15 | 2025-07-23 | |
| Assessing the Performance of Wesper Lab for Obstructive and Central Sleep Apnea Wesper Lab Home Sleep Apnea Test - Sleep Apnea, Sleep Apnea, Obstructive | Not applicable | Not yet recruiting | Wesper Inc | 100 | 2025-09-01 | 2025-07-31 |
| Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing Sleep-disordered Breathing (SDB), Aortic Valve Stenosis | Recruiting | Aristides Plaitis | 150 | 2025-07-20 | 2026-04-09 | |
| Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea Sivopixant, Placebo, Acetazolamide - Sleep Apnea | Phase 2 | Active not recruiting | Shionogi | 60 | 2025-04-02 | 2026-05-06 |
| Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study Sleep Disordered Breathing (SDB), Sleep Apnea | Recruiting | Xiangya Hospital of Central South University | 15000 | 2025-01-15 | 2025-04-03 | |
| CO2 Supplement for Treatment of Acute Mountain Sickness Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air - Acute Mountain Sickness, High Altitude | Not applicable | Completed | State Key Laboratory of Respiratory Disease | 46 | 2024-06-07 | 2024-12-18 |
| Relationship Between Breathing and Attention in Children With Ondine Syndrome neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task) - Ondine Syndrome, Congenital Central Hypoventilation Syndrome (CCHS) | Unknown | Assistance Publique - Hôpitaux de Paris | 20 | 2024-02-29 | 2024-03-29 | |
| Managing Opioid Related Sleep Apnea With Acetazolamide Acetazolamide, Placebo - Sleep-Disordered Breathing, Obstructive Sleep Apnea | Phase 2 | Completed | University of California, San Diego | 39 | 2023-10-18 | 2026-03-10 |
| Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction Heart Failure, Central Sleep Apnea | Completed | Zoll Medical Corporation | 200 | 2023-08-21 | 2025-02-10 | |
| The IPAd Study: Exploring the Association Between Insomnia and Positive Airway Pressure Adherence in Children Insomnia - Obstructive Sleep Apnea, Hypoventilation | Completed | The Hospital for Sick Children | 216 | 2023-05-16 | 2025-05-21 | |
| Screening of OSA in Hospitalized Stroke Patients Using BSP Belun Sleep platform - Sleep-Disordered Breathing, Sleep Architecture | Not applicable | Unknown | Taipei Medical University Shuang Ho Hospital | 120 | 2022-05-04 | 2022-07-20 |
| A Study of Breathing Sound-based Classification of Patients With Breathing Disorders polysomnography - Apnea | Unknown | Huai'an No.1 People's Hospital | 200 | 2021-12-01 | 2023-06-13 | |
| Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude Naltrexone Pill, Placebo - Altitude, Sleep Apnea, Central | Phase 4 | Completed | VA Loma Linda Health Care System | 16 | 2021-08-08 | 2023-04-26 |
| DreamKit Respiratory Effort Signal Validation DreamKit - Sleep Apnea, Obstructive, Sleep Apnea, Central | Not applicable | Completed | Philips Clinical & Medical Affairs Global | 11 | 2021-06-22 | 2022-11-30 |
| Central Sleep Apnea Treated by CO2 Supplied by a Novel Device novel device with a comfortable mask - Central Sleep Apnea | Not applicable | Completed | State Key Laboratory of Respiratory Disease | 18 | 2021-05-20 | 2022-03-31 |
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Sleep Apnea Syndromes (44) · Sleep Apnea, Obstructive (40) · Heart Failure (21) · Cheyne-Stokes Respiration (14) · Apnea (7) · Congenital central hypoventilation syndrome (4) · Respiratory Aspiration (3) · Stroke (3) · Heart Valve Diseases (2) · Hypoventilation (2) · Obesity (2) · Sleep Wake Disorders (2) · Agnosia (1) · Altitude Sickness (1)
Dyssomnias (94) · Respiration Disorders (94) · Sleep Disorders, Intrinsic (94) · Nervous System Diseases (93) · Respiratory Tract Diseases (93) · Sleep Wake Disorders (92) · Apnea (87) · Sleep Apnea Syndromes (50) · Pathological Conditions, Signs and Symptoms (29) · Cardiovascular Diseases (28) · Signs and Symptoms (26) · Heart Diseases (24) · Signs and Symptoms, Respiratory (21) · Nutritional and Metabolic Diseases (7) · Mental Disorders (6)
Acetazolamide (4) · Polysomnography (3) · Buspirone (2) · Neuropsychological Tests (2) · Oxygen (2) · Zolpidem (2) · Carbon Dioxide (1) · Cardiac Surgical Procedures (1) · Control Groups (1) · Desogestrel (1) · Drug Delivery Systems (1) · Hemodynamic Monitoring (1) · Magnetic Resonance Spectroscopy (1) · Morphine (1) · Naltrexone (1)
ResMed (8) · Philips Respironics (5) · Respicardia, Inc. (5) · VA Office of Research and Development (5) · Assistance Publique - Hôpitaux de Paris (4) · The Hospital for Sick Children (4) · Philips Clinical & Medical Affairs Global (3) · Heart and Diabetes Center North-Rhine Westfalia (2) · Imperial College London (2) · Nanjing Medical University (2) · State Key Laboratory of Respiratory Disease (2) · Universitaire Ziekenhuizen KU Leuven (2) · University Hospital, Grenoble (2) · Wissenschaftliches Institut Bethanien e.V (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1)
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Shahrokh Javaheri, MD (3) · Alan Schwartz, MD (2) · Kathy McPherson (2) · M Safwan Badr, MD (2) · Mark Goetting, MD (2) · Paul Wylie, MD (2) · Reshma Amin, MD (2) · Yuanming Luo, PhD (2) · Ali Vazir, PhD (1) · Andreas Fiene, BA Med,Surg. FRACP MD (1) · Anna Kazimierczak (1) · Anne Greenough, Professor (1) · Bill Hardy (1) · Charles V Smith, PhD (1)
PMID 14760162, PMID 20847081, PMID 21372306, PMID 21801857, PMID 21886365, PMID 22198979, PMID 22618923, PMID 22618924, PMID 23111478, PMID 23904676, PMID 24716484, PMID 25190260, PMID 25242802, PMID 25268234, PMID 25770408, PMID 25950507, PMID 26316510, PMID 26432647, PMID 26612581, PMID 26682790, PMID 26806668, PMID 27099761, PMID 27155898, PMID 27598679, PMID 27938912, PMID 28335841, PMID 29065956, PMID 29187390, PMID 30059750, PMID 30325462, PMID 31634407, PMID 31665026, PMID 31808012, PMID 32690535, PMID 32789619, PMID 32803641, PMID 32946372, PMID 32957983, PMID 33745107, PMID 33953626, PMID 35286569, PMID 36030769, PMID 36116293, PMID 36435158, PMID 37148831, PMID 37284759, PMID 37436669, PMID 37612192, PMID 38142697, PMID 38336689
I01CX001944 (1), I01RD001576 (1), K23HL151880 (1), R01HL130552 (1), R21HL137874 (1), R44NS042451 (1), U24HL140412 (1)