13 completed, 4 not yet recruiting, 3 recruiting, 3 terminated. 26 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 26 | Completed 13, Not yet recruiting 4, Recruiting 3, Terminated 3, Active not recruiting 1, Suspended 1, Withdrawn 1 |
Follow Sleep: new trials by email Literature Review of Sleep trials Research Report on Sleep
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sleep Outcomes and Multidimensional Sleep Assessment - a Randomized Trial of Dolutegravir- vs Doravirine-based Antiretroviral Therapy in People Living With HIV Tenofovir disoproxil fumarate 300mg / Lamivudine 300mg / Doravirine 100mg, Tenofovir disoproxil fumarate 300mg / Lamivudine 300mg / Dolutegravir 50mg - HIV (Human Immunodeficiency Virus), Sleep | Phase 4 | Not yet recruiting | University of Witwatersrand, South Africa | 40 | 2026-10-05 | 2026-10-06 |
| Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU Melatonin - Critical Illness, ICU | Phase 4 | Not yet recruiting | Rutgers, The State University of New Jersey | 30 | 2026-09-01 | 2026-07-13 |
| Light and Sleep Fragmentation Light therapy - Sleep, Mild Cognitive Impairment | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-06-01 | 2023-08-25 |
| Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep Disorders in China Psychotropic Drugs, Acupuncture - Anxiety Depression, Sleep | Phase 4 | Recruiting | Duke Kunshan University | 180 | 2026-04-01 | 2026-07-29 |
| Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking Daridorexant 50 mg, Placebo - Smoking, Nicotine | Phase 4 | Not yet recruiting | Legacy Health System | 44 | 2026-02-10 | 2026-01-09 |
| Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty Magnesium Threonate, Control - Sleep, Knee Osteoarthritis | Phase 4 | Recruiting | University of Miami | 64 | 2025-04-21 | 2026-07-09 |
| Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to Moderate Alzheimer Disease Daridorexant 50 mg, Placebo, Polysomnography - Alzheimer Disease, Insomnia Disorder | Phase 4 | Recruiting | University Hospital, Montpellier | 62 | 2024-03-13 | 2026-06-25 |
| Implications of Anesthetics on Sleep Consolidation Dexmedetomidine - Sleep | Phase 4 | Terminated | University of Chicago | 9 | 2020-10-16 | 2023-02-24 |
| Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial Fisher Wallace Neurostimulation Device - Insomnia, Insomnia Chronic | Phase 4 | Active not recruiting | ProofPilot | 200 | 2020-10-01 | 2021-01-14 |
| Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations Testosterone Undecanoate, Sesame Oil - Caloric Restriction, Exercise | Phase 4 | Completed | Pennington Biomedical Research Center | 34 | 2019-09-23 | 2022-10-07 |
| Pharmacological Treatment of Insomnia in Palliative Care Zopiclone, Placebo - Sleep, Insomnia | Phase 4 | Completed | St. Olavs Hospital | 43 | 2016-11-15 | 2021-07-16 |
| Acute Effects of Gabapentin in Sleep Parameters and Hormonal Release During Sleep in Older Men Gabapentin, Placebo - Sleep | Phase 4 | Terminated | Associação Fundo de Incentivo à Pesquisa | 8 | 2015-09-01 | 2016-07-13 |
| Usage of Baclofen for Sleep Improvement After Cardiac Surgery Baclofen, Placebo - Sleep | Phase 4 | Suspended | University of Liege | 30 | 2015-07-01 | 2016-05-13 |
| Vortioxetine for Menopausal Depression vortioxetine - Depression, Menopause | Phase 4 | Completed | Massachusetts General Hospital | 47 | 2015-06-12 | 2017-06-28 |
| The Effects of a Parental Intervention on Electronic Media Exposure and Sleep Patterns in Adolescents Meetings guides by experts in sleeping disorders. - Sleep | Phase 4 | Completed | HaEmek Medical Center, Israel | 70 | 2011-02-01 | 2015-02-18 |
| Optimize Astronaut Sleep Medication Efficacy and Individual Effects Zolpidem - Sleep, Cognition | Phase 4 | Completed | National Aeronautics and Space Administration (NASA) | 34 | 2011-01-10 | 2018-05-16 |
| The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Milnacipran, Placebo - Sleep Disorders, Fibromyalgia | Phase 4 | Completed | Mansoor Ahmed M.D. | 19 | 2010-11-01 | 2019-08-21 |
| Hypnotic Medications and Memory: Effect of Drug Exposure During the Night zaleplon, zolpidem extended release, bedtime placebo - Sleep, Memory | Phase 4 | Completed | St. Luke's Hospital, Chesterfield, Missouri | 26 | 2010-10-01 | 2014-08-26 |
| Sleep Intervention During Acute Lung Injury Dexmedetomidine, Midazolam and Fentanyl - Critical Illness, Sleep | Phase 4 | Completed | University of Arizona | 90 | 2009-08-01 | 2021-08-04 |
| Cyclobenzaprine Extended Release (ER) for Fibromyalgia cyclobenzaprine ER (AMRIX), placebo - Fibromyalgia, Pain | Phase 4 | Terminated | State University of New York - Upstate Medical University | 37 | 2009-06-01 | 2024-11-27 |
Showing 20 of 26. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (5) · Critical Illness (3) · Depression (2) · Fibromyalgia (2) · Acquired Immunodeficiency Syndrome (1) · Acute Lung Injury (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Behavior, Addictive (1) · Cognitive Dysfunction (1) · Fatigue (1) · Hot Flashes (1) · Insulin Resistance (1) · Mood Disorders (1) · Motor Activity (1)
Mental Disorders (9) · Nervous System Diseases (7) · Pathological Conditions, Signs and Symptoms (6) · Dyssomnias (5) · Sleep Disorders, Intrinsic (5) · Sleep Wake Disorders (5) · Behavior (4) · Disease Attributes (3) · Musculoskeletal Diseases (3) · Pathologic Processes (3) · Rheumatic Diseases (3) · Signs and Symptoms (3) · Behavioral Symptoms (2) · Muscular Diseases (2) · Neurocognitive Disorders (2)
Dexmedetomidine (4) · Fentanyl (2) · Midazolam (2) · Zolpidem (2) · daridorexant (2) · zaleplon (2) · Acupuncture Therapy (1) · Baclofen (1) · Diphenhydramine (1) · Eszopiclone (1) · Gabapentin (1) · Ibuprofen (1) · Isoflurane (1) · Lamivudine (1) · Melatonin (1)
St. Luke's Hospital, Chesterfield, Missouri (2) · University of Arizona (2) · University of Chicago (2) · Associação Fundo de Incentivo à Pesquisa (1) · Bayer (1) · Central Institute of Psychiatry, Ranchi, India (1) · Duke Kunshan University (1) · Duke University (1) · HaEmek Medical Center, Israel (1) · Legacy Health System (1) · Mansoor Ahmed M.D. (1) · Massachusetts General Hospital (1) · National Aeronautics and Space Administration (NASA) (1) · Pennington Biomedical Research Center (1) · ProofPilot (1)
United States (16) · Belgium (1) · Brazil (1) · China (1) · France (1) · India (1) · Norway (1)
Sairam Parthasarathy, MD (2) · Anna Clebone, MD (1) · Ariel Koren, MD (1) · Claudia Nisa (1) · David B MacLeod, MD (1) · David Dinges, PhD (1) · Francois WD Venter, PhD (1) · Jag Sunderram (1) · James K Walsh, Ph.D. (1) · Janine M Hall-Porter, PhD (1) · Jennifer C Rood, PhD (1) · Mansoor Ahmed, MD (1) · Marlene P Freeman, MD (1)
PMID 26414990, PMID 30576525, PMID 34278044, PMID 36534165, PMID 36796647, PMID 36949577, PMID 40279652
2015 (1), R01HL095748 (1)