102 completed, 32 unknown, 11 recruiting, 9 withdrawn. 67 Not applicable, 35 Phase 2, 26 Phase 3, 20 Phase 4, 19 Phase 1.
Follow Arginine: new trials by email Literature Review of Arginine trials Research Report on Arginine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted Nutritional Intervention (HMB, Arginine, Glutamine) in Patients With Pancreatic Cancer HMB / L-Arginine / L-Glutamine oral nutritional mixture, Standard Dietary Counseling - PDAC, Pancreas Adenocarcinoma (MSI-H) | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2026-12-01 | 2026-10-20 |
| Study of Supplemental Arginine With Chemotherapy and Immunotherapy in Platinum Resistant Ovarian, Fallopian Tube, and Peritoneal Cancer (Arginaid®) Oral Arginine, (R-Gene® 10) IV Arginine, Pembrolizumab - Platinum Resistant Ovarian Cancer, Fallopian Tube Cancers | Phase 1 | Not yet recruiting | Rebecca Arend | 24 | 2026-09-01 | 2026-10-15 |
| Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery L-arginine - Acute Kidney Injury | Completed | Xijing Hospital | 5135 | 2026-07-20 | 2026-11-12 | |
| Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies 8% arginine + Zinc toothpaste, 5% Calcium Sodium Phosphosilicate toothpaste, 8% arginine toothpaste - Dentinal Sensitivity, Dentinal Hypersensitivity | Phase 3 | Recruiting | Colgate Palmolive | 132 | 2026-06-29 | 2026-08-07 |
| NON-SURGİCAL PERİODONTAL THERAPY WİTH L-ARGİNİNE L-arginine 0.8% subgingival irrigation, Saline 0.9% subgingival irrigation (placebo), Scaling and root planing - Periodontal Disease, Periodontal Diseases | Not applicable | Active not recruiting | Alanya Alaaddin Keykubat University | 60 | 2026-06-01 | 2026-10-23 |
| Immunonutrition for Surgical Prehabilitation of Patients With Upper GI Cancer Oral nutritional supplements with immunonutrition (enriched with arginine, nucleotides, vitamin D and omega-3-fatty acid), Standart of care - Upper GI Cancer | Not applicable | Enrolling by invitation | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 110 | 2026-01-01 | 2026-10-20 |
| Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes Arginine hydrochloride, Sodium Chloride 0.9% - Diabetes (DM), Diabetic Ketoacidosis | Phase 1 / Phase 2 | Recruiting | David K Carroll | 60 | 2025-12-19 | 2026-02-12 |
| RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma Actinium Ac 225 DOTATATE RYZ101, Biospecimen Collection, Computed Tomography - Recurrent Meningioma | Phase 1 / Phase 2 | Recruiting | Joshua Palmer | 30 | 2025-11-12 | 2026-08-13 |
| Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients L-Arginine, Placebo - Cognition Disorders in Old Age, Cognitive and Behavioral Impairment | Phase 2 | Recruiting | German University in Cairo | 60 | 2025-08-27 | 2026-01-21 |
| Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity Toothpaste containing 8% Arginine, Colgate Cavity Protection Toothpaste - Hypersensitivity | Phase 3 | Completed | Colgate Palmolive | 80 | 2025-07-14 | 2025-12-05 |
| Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant Women L-Arginine, placebo - Pre-eclampsia | Not applicable | Completed | Quaid-e-Azam Medical College | 108 | 2025-07-01 | 2026-11-03 |
| Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE) Human albumin infusion at a modified dosage, Human albumin infusion at a routine dosage, Lactulose - Overt Hepatic Encephalopathy | Not applicable | Recruiting | General Hospital of Shenyang Military Region | 174 | 2025-06-24 | 2025-08-26 |
| Perioperative Use of Amino Acids in Recipients of Orthotopic Liver Transplantation as a Renal Protective Factor Amino acid solution, Amino Acid infusion - Hepatic Failure, Liver Transplant | Not applicable | Not yet recruiting | Hospital Dr Sotero del Rio | 90 | 2025-05-27 | 2025-06-04 |
| Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic and Cognitive Performance in Recreationally Active Males Creatine Monohydrate, L-Arginine, Placebo - Anaerobic Performance, Cognitive Performance | Not applicable | Completed | Inonu University | 18 | 2025-04-01 | 2026-04-23 |
| Acute Effects of BCAA and L-Arginine on Performance in Elite Soccer Players BCAA, L-Arginine, bcaa and l arginine - Ergogenic Support and Performance | Not applicable | Completed | Ataturk University | 21 | 2025-01-10 | 2026-01-16 |
| Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases Arginine, Biospecimen Collection, Computed Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Early Phase 1 | Recruiting | Emory University | 10 | 2024-09-05 | 2026-10-13 |
| Comparison Between Treatments of Oligohydramnios Sildenafil 25 MG, L-Arginine, 1000 Mg Oral Tablet - Oligohydramnios | Phase 2 | Unknown | Kafrelsheikh University | 40 | 2024-09-01 | 2025-08-21 |
| The Effects of L-arginine Supplementation on Anaerobic Exercise Performance L-arginine, Placebo - Skeletal Muscle, Human Performance | Not applicable | Unknown | University of Manitoba | 20 | 2024-06-14 | 2024-06-26 |
| Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients Myoinositol, Chromium, l-arginine - Polycystic Ovary Syndrome | Phase 3 | Completed | Beni-Suef University | 240 | 2024-06-05 | 2026-11-12 |
| L-arginine for Knee Osteoarthritis Patients L-arginine tablet, Placebo tablet - Osteoarthritis, Knee | Not applicable | Recruiting | Xiangya Hospital of Central South University | 340 | 2024-03-20 | 2025-06-02 |
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Anemia, Sickle Cell (8) · Dentin Sensitivity (7) · Diabetes Mellitus (7) · Hypertension (7) · Diabetes Mellitus, Type 2 (6) · Malnutrition (6) · Cardiovascular Diseases (5) · Dental Caries (5) · Insulin Resistance (5) · Dwarfism, Pituitary (4) · Pre-Eclampsia (4) · Premature Birth (4) · Erectile Dysfunction (3) · Glucose Intolerance (3) · Inflammation (3)
Colgate Palmolive (4) · Emory University (4) · Maastricht University Medical Center (4) · Ain Shams University (3) · The First Affiliated Hospital of Zhengzhou University (3) · UCSF Benioff Children's Hospital Oakland (3) · Wake Forest University Health Sciences (3) · Brigham and Women's Hospital (2) · IRCCS San Raffaele (2) · Liverpool Women's NHS Foundation Trust (2) · Mayo Clinic (2) · Menzies School of Health Research (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Texas A&M University (2) · The Hospital for Sick Children (2)
United States (54) · Italy (12) · Egypt (11) · Canada (8) · China (8) · Turkey (Türkiye) (7) · United Kingdom (6) · Brazil (5) · France (5) · Germany (5) · Netherlands (4) · Denmark (3) · Mexico (3) · Pakistan (3) · Austria (2)
Claudia Morris, MD (2) · Peter J Joris, PhD (2) · PierMarco Piatti, MD (2) · Alan R. Cohen, MD (1) · Alfredo H Navigante, MD, Phd (1) · Allen Waziri, MD (1) · Alvin Wong (1) · Anna P Ralph, MBBS (1) · Ayman W El-Hattab, MD (1) · Azam Bakhshandeh, PhD (1) · Bennet Amaechi, PhD, DDS (1) · Brendan Lee, MD, PhD (1) · Carlton Dampier, MD (1) · Carolyn Bigelow, MD (1) · Cassiano K Rosing, PhD (1)
PMID 32384147, PMID 42549972, PMID 10851208, PMID 11927799, PMID 12119802, PMID 12449285, PMID 12923400, PMID 15198963, PMID 15738343, PMID 16391172, PMID 16391217, PMID 16533484, PMID 17364057, PMID 17636753, PMID 18426998, PMID 18545693, PMID 18626628, PMID 18816238, PMID 19047577, PMID 19488737, PMID 19562567, PMID 19738158, PMID 19786331, PMID 19941706, PMID 20484311, PMID 21596735, PMID 22199246, PMID 22801444, PMID 23266540, PMID 23333044, PMID 23645695, PMID 23778831, PMID 23830159, PMID 23872605, PMID 23967066, PMID 24237764, PMID 24363760, PMID 24401239, PMID 24746974, PMID 24810310, PMID 25153328, PMID 25644339, PMID 25861285, PMID 25993630, PMID 26385052, PMID 26694707, PMID 26799743, PMID 26865647, PMID 27003763, PMID 27216309
2009 (2), K24AT009893 (2), U10CA081851 (2), 2005 (1), 2018 (1), P01AI050153 (1), P30CA016672 (1), P30CA138292 (1), P50HL083800 (1), R01AG015466 (1), R01DE025832 (1), R01DK097550 (1), R01HL063685 (1), R01HL070059 (1), R01HL075774 (1)