22 completed, 5 unknown, 4 active not recruiting, 4 recruiting. 16 Phase 2, 10 Phase 3, 8 Phase 1, 7 Phase 4, 3 Not applicable.
Follow hydrocortisone hemisuccinate: new trials by email Literature Review of hydrocortisone hemisuccinate trials Research Report on hydrocortisone hemisuccinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression - Sepsis and Septic Shock, Acute Respiratory Failure | Phase 4 | Recruiting | University Hospital, Strasbourg, France | 212 | 2026-08-11 | 2026-08-20 |
| A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome | Phase 1 | Recruiting | Children's Oncology Group | 36 | 2025-02-04 | 2026-08-25 |
| A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia Biospecimen Collection, Bone Marrow Aspiration, Calaspargase Pegol - Recurrent Acute Leukemia of Ambiguous Lineage, Recurrent Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | Children's Oncology Group | 78 | 2024-01-08 | 2026-08-25 |
| A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat Anti-CD123 ADC IMGN632, Bone Marrow Aspiration and Biopsy, Cytarabine - Recurrent Acute Myeloid Leukemia, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Withdrawn | Children's Oncology Group | 2023-08-01 | 2023-09-01 | |
| Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New Onset AF After CABG Surgery Dexmedetomidine + Hydrocortisone - Atrial Fibrillation New Onset | Early Phase 1 | Unknown | Ain Shams University | 248 | 2022-12-25 | 2023-01-10 |
| HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study Hydrocortisone, Placebo - Healthcare-Associated Pneumonia, Ventilator Associated Pneumonia | Not applicable | Completed | Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo | 180 | 2022-10-16 | 2026-08-13 |
| Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone. Solu-Cortef - Oral Pyogenic Granuloma | Phase 2 / Phase 3 | Unknown | Beni-Suef University | 30 | 2022-05-01 | 2022-09-14 |
| The Effects of Two Brands of Hydrocortisone Injected Intramuscularly Into Deltoid and Thigh Muscles Solu-Cortef 100 MG Injection, Hydrocortisone 100mg/ml - Addison's Disease | Phase 4 | Unknown | The London Clinic | 8 | 2022-03-14 | 2022-04-27 |
| Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates Hydrocortisone - Hypoxic-Ischemic Encephalopathy, Asphyxia | Phase 4 | Recruiting | Semmelweis University | 50 | 2021-09-21 | 2026-04-28 |
| Glucocorticoid Administration After Traumatic Birth Intravenous (IV) hydrocortisone - Traumatic Birth | Phase 1 | Completed | University of Michigan | 133 | 2021-05-21 | 2022-11-09 |
| A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) 3-Dimensional Conformal Radiation Therapy, Asparaginase Erwinia chrysanthemi, Biospecimen Collection - Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 461 | 2020-12-17 | 2026-09-01 |
| Hydrocortisone for COVID-19 and Severe Hypoxia Hydrocortisone, Sodium Chloride 9mg/mL - Covid-19, Hypoxia | Phase 3 | Completed | Scandinavian Critical Care Trials Group | 30 | 2020-04-17 | 2021-09-21 |
| Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women Ketoconazole Pill (also known as nizoral), Ganirelix, Dexamethasone Pill - Sleep Restriction | Early Phase 1 | Active not recruiting | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 5 | 2020-02-09 | 2025-09-11 |
| Hormonal Mechanisms of Sleep Restriction - Axis Study Ketoconazole Pill, Ganirelix, Dexamethasone - Sleep Restriction | Phase 1 | Active not recruiting | Peter y. Liu | 80 | 2017-05-08 | 2025-09-11 |
| Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Azacitidine, Biospecimen Collection, Computed Tomography - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2017-04-01 | 2025-02-27 |
| Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Hydrocortisone, Placebo - Hypoxic-Ischemic Encephalopathy, Asphyxia | Phase 2 / Phase 3 | Completed | Semmelweis University | 32 | 2016-02-01 | 2023-04-21 |
| A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma Temsirolimus, Etoposide, Cyclophosphamide - Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Lymphoma | Phase 1 | Completed | Therapeutic Advances in Childhood Leukemia Consortium | 16 | 2015-07-03 | 2023-07-27 |
| Treatment of Apomorphine-induced Skin Reactions: a Pilot Study Apomorphine 0.25% (2.5mg/ml), Massage with a spiky ball, Hydrocortisone cream 1% - Parkinson's Disease, Apomorphine-induced Skin Reactions | Phase 2 | Terminated | University Medical Center Groningen | 13 | 2015-06-01 | 2024-03-13 |
| Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Hydrocortisone, Saline - Intussusception | Not applicable | Unknown | Cairo University | 80 | 2015-04-01 | 2024-08-27 |
| Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Bortezomib, Cyclophosphamide, Cytarabine - Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 847 | 2014-10-04 | 2026-10-21 |
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Burkitt Lymphoma (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Addison Disease (4) · Leukemia (4) · Adrenal Hyperplasia, Congenital (3) · Leukemia, Biphenotypic, Acute (3) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (3) · Sepsis (3) · Shock, Septic (3) · Asphyxia (2) · Hypoxia-Ischemia, Brain (2) · Leukemia, Myelomonocytic, Juvenile (2) · Recurrence (2) · Shock (2) · Adrenal Insufficiency (1)
Children's Oncology Group (6) · National Cancer Institute (NCI) (5) · Haukeland University Hospital (4) · Semmelweis University (2) · Therapeutic Advances in Childhood Leukemia Consortium (2) · Ain Shams University (1) · Association Niçoise de Réanimation Médicale (1) · Baylor College of Medicine (1) · Beni-Suef University (1) · Cairo University (1) · Children's Hospital of Eastern Ontario (1) · Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · M.D. Anderson Cancer Center (1) · National Taiwan University Hospital (1)
United States (18) · Australia (9) · Canada (9) · New Zealand (5) · Puerto Rico (5) · Norway (4) · Egypt (3) · United Kingdom (3) · Denmark (2) · France (2) · Hungary (2) · Netherlands (2) · Switzerland (2) · Brazil (1) · China (1)
Peter Liu, MD, PhD (2) · Alan S. Gamis, MD, MPH (1) · Alexandra M Stevens (1) · Anders Perner, MD, PhD (1) · Andrew Wolf, MBBChir MD (1) · Balasubramanian Venkatesh (1) · Barbara L. Asselin, MD (1) · Carrol Gamble, PhD (1) · David T Teachey (1) · Diana M Gibb, MBChB MD (1) · Elizabeth Raetz, MD (1) · Eman Magdy, PhD (1) · Gamal El Tagy, MD (1)
PMID 12011123, PMID 19029421, PMID 21849481, PMID 22392565, PMID 24276047, PMID 27153945, PMID 29347874, PMID 29812996, PMID 30117142, PMID 31155392, PMID 32496902, PMID 33242441, PMID 34138478, PMID 34218046, PMID 35067914, PMID 35271306, PMID 35272029, PMID 35622074, PMID 36603187, PMID 37172949, PMID 37853343, PMID 37890117, PMID 38239409, PMID 38457359, PMID 38867582, PMID 39121442, PMID 40289414, PMID 40983658, PMID 41586417, PMID 41671463
U10CA180886 (6), U10CA098543 (4), 2009 (1), P30CA016672 (1), U10CA030969 (1), UM1CA228823 (1)