62 completed, 17 unknown, 15 recruiting, 8 not yet recruiting. 53 Not applicable, 9 Phase 2, 7 Phase 3, 6 Phase 4, 5 Phase 1.
Follow Cleft Palate: new trials by email Literature Review of Cleft Palate trials Research Report on Cleft Palate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Furlow With Buccinator and Fistula Formation furlow with buccinator, two flap palatoplasty - Cleft Palate | Not applicable | Not yet recruiting | Fayoum University | 20 | 2026-09-25 | 2026-09-25 |
| Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF in Cleft Palate Standard palatoplasty ( control), Platelet _ Rich Fibrin ( PRF), gentamicin_ loaded PRF - Cleft Palate, Unilateral Cleft Palate | Not applicable | Recruiting | Al-Thawra Modern General Hospital | 90 | 2026-08-01 | 2026-08-07 |
| Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip Non-linear based phonological speech intervention, Linear-based speech intervention - Cleft Palate +/- Lip | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 12 | 2026-07-24 | 2026-07-09 |
| Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring Standard General Anesthesia per Institutional Protocol - Cleft Palate, Cleft Lip | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 150 | 2026-06-27 | 2026-06-16 | |
| MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair Modified Furlow Palatoplasty combined with buccinator myomucosal flap - Cleft Palate, Cleft Palate, Unilateral, Complete | Not applicable | Not yet recruiting | Cairo University | 10 | 2026-06-01 | 2026-04-07 |
| Speech Intervention Via Telepractice for Children With Repaired Cleft Palate Speech therapy via teleprace, Face-to-face speech therapy - Cleft Palate Children, Speech Sound Disorder | Not applicable | Not yet recruiting | Texas Tech University Health Sciences Center | 64 | 2026-03-02 | 2026-02-27 |
| Effects of AlignBabyCleft (ABaCleft) Appliance. Orthodontic appliance to carry out dentoalveolar movement - Cleft Lip, Cleft Palate | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 30 | 2025-11-21 | 2025-04-25 |
| Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation. Early intervention for language, articulation and palatal function skills - Cleft Lip and Cleft Palate, Cleft Lip Palate | Not applicable | Not yet recruiting | Old Dominion University | 200 | 2025-10-21 | 2025-10-22 |
| Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate Mailing and completing CLEFT-Q and NOSE questionnaires - Cleft Lip and Cleft Palate | Recruiting | University Hospital, Montpellier | 80 | 2025-07-09 | 2025-07-22 | |
| Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery Methadone hydrochloride, Fentanyl/Hydromorphone - Cleft Palate, Pain | Phase 4 | Recruiting | Duke University | 60 | 2025-06-04 | 2026-04-14 |
| Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate Plasma Rich in Growth Factors (PRGF), Placebo - Cleft Palate, Plasma Rich in Growth Factors | Not applicable | Not yet recruiting | Cairo University | 36 | 2025-04-01 | 2025-03-21 |
| Effect of Furlow Palatoplasty With Buccal Myomucosal Flap on the Speech Development furlow with buccal myomucosal flap, two flap palatoplasty - Cleft Palate | Recruiting | Fayoum University | 30 | 2025-03-25 | 2025-07-28 | |
| Expiratory Muscle Strength Training for Hypernasal Speech in Children Expiratory Muscle Strength Training, Maintenance Training - Velopharyngeal Insufficiency, Velopharyngeal Incompetence Due to Cleft Palate | Not applicable | Recruiting | Noel Jabbour | 30 | 2025-03-03 | 2026-07-20 |
| The Financial and Emotional Impact of Cleft Palate Questionnaires, Semi-structured interviews - Cleft Lip and Cleft Palate | Recruiting | University Hospital, Ghent | 300 | 2025-03-01 | 2025-04-01 | |
| Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate PCR - Cleft Lip and Cleft Palate | Not yet recruiting | Assiut University | 200 | 2025-01-01 | 2024-12-12 | |
| Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF) Serous Otitis, Tympanic Membrane Perforation | Unknown | University Hospital, Brest | 500 | 2024-12-12 | 2024-12-18 | |
| Improving the Outcomes of Nasoalveolar Molding in Complete Bilateral Cleft Lip and Palate Neonates Using a Modification in the Design of the Conventional Molding Appliance. vomer molding appliance, conventional molding appliance - Cleft Lip and Cleft Palate, Cleft Lip Bilateral | Not applicable | Completed | Tanta University | 20 | 2024-12-01 | 2026-09-11 |
| Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI real time MRI - Velopharyngeal Insufficiency, Real Time MRI | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 30 | 2024-11-06 | 2026-06-15 |
| Evaluation of Nasal Elevator Versus Grayson's Nasal Stent with D-NAM Appliance on Nasolabial Esthetics in Bilateral Cleft Lip and Palate Infants Nasal elevator with digital nasoalveolar molding in bilateral cleft lip and palate infants, Nasal stent with digital nasoalveolar molding in bilateral cleft lip and palate infants - Cleft Lip and Cleft Palate | Phase 1 | Unknown | Cairo University | 20 | 2024-11-01 | 2024-10-17 |
| QL vs LAI for Palatoplasty Quadratus lumborum block, Local anesthetic infiltration - Post-operative Pain, Opioid Use | Not applicable | Recruiting | Medical University of South Carolina | 46 | 2024-06-25 | 2026-07-09 |
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Cleft Lip (44) · Velopharyngeal Insufficiency (6) · Congenital Abnormalities (5) · Pain, Postoperative (4) · Retrognathia (4) · Speech (4) · Agnosia (3) · Craniofacial Abnormalities (3) · Otitis Media (3) · Airway Obstruction (2) · Communication Disorders (2) · Maxillofacial Abnormalities (2) · Mouth Abnormalities (2) · Pain (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (114) · Mouth Diseases (114) · Jaw Abnormalities (113) · Jaw Diseases (113) · Musculoskeletal Abnormalities (113) · Musculoskeletal Diseases (113) · Stomatognathic Diseases (113) · Stomatognathic System Abnormalities (113) · Maxillofacial Abnormalities (112) · Mouth Abnormalities (112) · Craniofacial Abnormalities (111) · Congenital Abnormalities (109) · Lip Diseases (44) · Pathological Conditions, Signs and Symptoms (19) · Neurologic Manifestations (13)
Bupivacaine (5) · Saline Solution (4) · Acetaminophen (3) · Dexmedetomidine (3) · Fentanyl (2) · Folic Acid (2) · Levobupivacaine (2) · Nasoalveolar Molding (2) · Sodium Chloride (2) · Surveys and Questionnaires (2) · Amoxicillin (1) · Ampicillin (1) · Anti-Bacterial Agents (1) · Audiometry (1) · Botulinum Toxins, Type A (1)
Assiut University (6) · Cairo University (6) · Fayoum University (4) · University Hospital, Basel, Switzerland (4) · Tanta University (3) · University of Florida (3) · University of Pittsburgh (3) · Asan Medical Center (2) · Centre Hospitalier Universitaire, Amiens (2) · Duke University (2) · Mansoura University (2) · NICHD Global Network for Women's and Children's Health (2) · Noel Jabbour (2) · Oslo University Hospital (2) · Pontifícia Universidade Católica de Minas Gerais (2)
United States (29) · Egypt (23) · France (9) · Canada (7) · Brazil (6) · Belgium (4) · Norway (4) · Sweden (4) · Switzerland (4) · Indonesia (2) · Netherlands (2) · South Korea (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Czechia (1)
Cuneyt M Alper, MD (2) · Jeff Murray, M.D. (2) · Alexander C Allori, MD, MPH (1) · Allen Wilcox, M.D. (1) · Andrzej Brudnicki, MD DDS PhD (1) · Ashley Lentz, MD (1) · Axel Sauter, MD PhD (1) · Benitez Benito, MD DMD (1) · Benito K Benitez, MD DDS MHBA (1) · Benito K Benitez, MD DMD (1) · Brent Collett, PhD (1) · Cameron R Smith, MD, PhD (1)
PMID 14707617, PMID 1472517, PMID 16563165, PMID 18452361, PMID 19854614, PMID 21091369, PMID 21740160, PMID 21823827, PMID 22204448, PMID 22230559, PMID 22682069, PMID 23181832, PMID 23643382, PMID 23669628, PMID 24525630, PMID 25394172, PMID 27053961, PMID 27533493, PMID 28921849, PMID 31300507, PMID 31795731, PMID 32049908, PMID 32081579, PMID 32423402, PMID 33107321, PMID 33397459, PMID 33827851, PMID 34896005, PMID 35100923, PMID 35874558, PMID 36721240, PMID 37530892, PMID 37541047, PMID 37646677, PMID 38253979, PMID 39271956, PMID 39791255, PMID 40216530, PMID 41420755, PMID 41930721, PMID 8547288
R21DC017553 (2), 2014 (1), P50DC007667 (1), R01DC011524 (1), R01DE010437 (1), R21HL087819 (1), U01DE017958 (1), U01DE018837 (1), U01DE020057 (1), U01HD040561 (1)