Drug-Related Side Effects and Adverse Reactions: Clinical Trials

497 completed, 259 unknown, 133 recruiting, 69 terminated. 298 Not applicable, 184 Phase 2, 94 Phase 3, 84 Phase 1, 69 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	298	Completed 133, Unknown 77, Recruiting 39, Terminated 15, Not yet recruiting 14, Withdrawn 10, Active not recruiting 8, Enrolling by invitation 1, Suspended 1
Phase 2	184	Completed 80, Unknown 42, Terminated 26, Recruiting 14, Withdrawn 11, Not yet recruiting 7, Active not recruiting 3, Suspended 1
Phase 3	94	Completed 47, Unknown 19, Terminated 11, Recruiting 7, Not yet recruiting 4, Active not recruiting 3, Withdrawn 2, Enrolling by invitation 1
Phase 1	84	Completed 46, Unknown 12, Recruiting 10, Not yet recruiting 5, Terminated 5, Withdrawn 5, Active not recruiting 1
Phase 4	69	Completed 37, Unknown 16, Terminated 5, Recruiting 4, Not yet recruiting 3, Active not recruiting 2, Withdrawn 2
Early Phase 1	8	Not yet recruiting 2, Active not recruiting 1, Completed 1, Enrolling by invitation 1, Suspended 1, Terminated 1, Unknown 1

Follow this condition Literature Review of Drug-Related Side Effects and Adverse Reactions trials Research Report on Drug-Related Side Effects and Adverse Reactions

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis Site specific standard of care comparison - Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis		Withdrawn	Massachusetts General Hospital		2030-01-01	2026-01-16
Maximizing Quality of Life After Cancer Through Rehabilitation TIMELY REHAB - Head and Neck Cancer, Hearing Loss	Not applicable	Not yet recruiting	VA Office of Research and Development	74	2027-03-01	2026-06-03
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome) Benralizumab 30 MG/ML [Fasenra], Placebo Comparator: Placebo-Control Arm 0.9% Sodium Chloride - DRESS Syndrome	Phase 2	Not yet recruiting	University Hospital, Lille	96	2027-01-06	2026-05-15
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants) Fexuprazan, NOAC therapy - Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)	Not applicable	Not yet recruiting	Ewha Womans University Mokdong Hospital	1000	2026-12-01	2026-03-27
IPGx PILOT Whole Genome Sequencing Extension Cohort Adverse Drug Reaction (ADR), Polypharmacy Patients		Recruiting	Texas A&M University	50	2026-12-01	2026-09-30
PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease		Not yet recruiting	Medical College of Wisconsin	60	2026-12-01	2025-10-14
Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced Cardiotoxicity 68Ga-Galmydar, PET/MRI, 18F-FDG - Lymphoma Cancer, Breast Cancer	Phase 1	Not yet recruiting	Washington University School of Medicine	36	2026-11-01	2026-09-24
Monitoring for CardioToxicity Using WeArable deVices While Undergoing cancEr Treatments (MCT-WAVE) Mobile Cardiac Telemetry, Wearable Cardiac Monitor - Cardiotoxicity, Cancer	Not applicable	Not yet recruiting	University of Minnesota	72	2026-10-29	2026-10-06
Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI) Cardiotoxicity, Cardiac Biomarkers		Not yet recruiting	South Tees Hospitals NHS Foundation Trust	300	2026-10-12	2026-10-08
Prevalence and Prognosis of Drug-Induced Liver Injury Drug-Induced Liver Injury		Not yet recruiting	Assiut University	80	2026-10-01	2026-09-21
SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases	Phase 2	Not yet recruiting	Cedars-Sinai Medical Center	30	2026-10-01	2026-09-30
Cardioprotection Effect of Linagliptin Doxorubicin, Empaglifloz 5 mg orally once daily - Cardiotoxicity	Phase 3	Not yet recruiting	Tanta University	140	2026-10-01	2026-10-15
Real World Asparaginase Therapy Toxicity Drug Toxicity		Not yet recruiting	St. Jude Children's Research Hospital	200	2026-10-01	2026-09-17
Subconjunctival Humira for Boston Keratoprosthesis Adalimumab Injection - Penetrating Keratoplasty, Multiple Graft Failure	Phase 1	Not yet recruiting	Massachusetts Eye and Ear Infirmary	8	2026-10-01	2026-08-31
Silymarin Versus N-Acetylcysteine as Protective Effect Against Anti-tuberculosis Drugs Induced Liver Injury. Antituberculosis drugs Group - Drug-Induced Acute Liver Injury, Tuberculosis (TB)	Early Phase 1	Not yet recruiting	Assiut University	102	2026-10-01	2026-10-21
Traditional Chinese Medicine Treatment for Capecitabine-Related Hand-Foot Syndrome Twelve-Ingredient Prepared Sichuan Aconite Hand and Foot Bath, Standard Basic Nursing Interventions - Palmar and Plantar Erythema, Numbness of the Four Limbs	Early Phase 1	Not yet recruiting	Emeishan Hospital of Traditional Chinese Medicine	7	2026-10-01	2026-10-20
Post-market Safety Study of LUMISIGHT Hypersensitivity Reactions		Recruiting	Lumicell, Inc.	1500	2026-09-30	2026-10-14
Heart Failure in Women: Epidemiological and Prognostic Insights Heart Failure		Recruiting	Carolina Ortiz Cortes	430	2026-09-17	2026-10-21
Misocholic Tablets for Non-Viral Elevated Liver Enzymes Misocholic Tab, Placebo, Silymarin (Silybum marianum) - Alcohol-Related Liver Disease, Drug-Induced Liver Injury	Phase 3	Not yet recruiting	Hanoi Medical University	60	2026-09-15	2026-09-22
OCCUPATIONAL NOISE AND CHEMICAL EXPOSURE EFFECTS ON AUDITORY AND VESTIBULAR FUNCTION Occupational Noise Exposure		Not yet recruiting	Ondokuz Mayıs University	50	2026-09-03	2026-09-08

Showing 20 of 1091. Sign in to see all of them.

Narrower conditions

Cardiotoxicity (255)  ·  Breast Neoplasms (147)  ·  Chemical and Drug Induced Liver Injury (80)  ·  Neoplasms (80)  ·  Drug Hypersensitivity (55)  ·  Ototoxicity (49)  ·  Heart Failure (48)  ·  Hand-Foot Syndrome (42)  ·  Stevens-Johnson Syndrome (40)  ·  Chemotherapy-Related Cognitive Impairment (39)  ·  Serotonin Syndrome (35)  ·  Lymphoma (28)  ·  Injection Site Reaction (20)  ·  Lung Neoplasms (19)

Broader conditions

Chemically-Induced Disorders (1090)  ·  Pathological Conditions, Signs and Symptoms (474)  ·  Pathologic Processes (417)  ·  Wounds and Injuries (329)  ·  Radiation Injuries (307)  ·  Neoplasms (294)  ·  Cardiovascular Diseases (282)  ·  Heart Diseases (265)  ·  Skin and Connective Tissue Diseases (248)  ·  Skin Diseases (247)  ·  Neoplasms by Site (239)  ·  Immune System Diseases (154)  ·  Breast Diseases (146)  ·  Digestive System Diseases (128)

Interventions

Cisplatin (24)  ·  Doxorubicin (22)  ·  Cyclophosphamide (21)  ·  Amifostine (19)  ·  Echocardiography (18)  ·  Radiotherapy (18)  ·  Acetylcysteine (16)  ·  Etoposide (13)  ·  Filgrastim (13)  ·  Dexrazoxane (11)  ·  Carboplatin (10)  ·  Exercise (10)  ·  Paclitaxel (10)  ·  Blood Specimen Collection (9)  ·  Docetaxel (9)

Sponsors

Assistance Publique - Hôpitaux de Paris (15)  ·  University Hospital, Montpellier (14)  ·  Abramson Cancer Center at Penn Medicine (10)  ·  Brigham and Women's Hospital (10)  ·  Groupe Hospitalier Pitie-Salpetriere (9)  ·  Peking University Third Hospital (9)  ·  Seoul National University Hospital (9)  ·  Beijing 302 Hospital (8)  ·  Children's Oncology Group (8)  ·  Massachusetts General Hospital (8)  ·  University of British Columbia (8)  ·  Assiut University (7)  ·  Hospices Civils de Lyon (7)  ·  Johns Hopkins University (7)  ·  VA Office of Research and Development (7)

Countries

United States (319)  ·  China (115)  ·  France (94)  ·  Canada (67)  ·  United Kingdom (49)  ·  Spain (42)  ·  Italy (33)  ·  Netherlands (31)  ·  Turkey (Türkiye) (30)  ·  Egypt (29)  ·  Germany (27)  ·  South Korea (26)  ·  Brazil (23)  ·  Belgium (22)  ·  Denmark (18)

Top investigators

Bonnie Ky, MD, MSCE (6)  ·  Xiao-he Xiao (6)  ·  Jettanong Klaewsongkram, MD (4)  ·  Pablo Lapuerta, MD (4)  ·  Xinyan Zhao (4)  ·  Cafer Zorkun, MD PhD (3)  ·  Chengwei Chen (3)  ·  Clifford Wang, MD (3)  ·  Doh Kwan Kim, M.D., Ph.D. (3)  ·  Edward A. Neuwelt, MD (3)  ·  John P Carey, MD (3)  ·  Marielle Scherrer-Crosbie, MD, PhD (3)

Results publications

PMID 31723056, PMID 26400476, PMID 28715540, PMID 32146619, PMID 33283229, PMID 33546752, PMID 34598813, PMID 36207229, PMID 10103341, PMID 10459293, PMID 10586010, PMID 10761937, PMID 11263649, PMID 11913479, PMID 11917283, PMID 11981287, PMID 12458299, PMID 12558848, PMID 12623040, PMID 12746667, PMID 12907084, PMID 12948221, PMID 13211322, PMID 14349898, PMID 15161841, PMID 15255031, PMID 15287367, PMID 15304586, PMID 15473335, PMID 15477280, PMID 15690283, PMID 15800308, PMID 15999362, PMID 16015544, PMID 16131888, PMID 16331093, PMID 16332601, PMID 16374442, PMID 16501396, PMID 16568436, PMID 16792436, PMID 16816511, PMID 17003295, PMID 17036033, PMID 17068719, PMID 17336213, PMID 17450108, PMID 17460134, PMID 17518411, PMID 17588298

NIH funding

2017 (4), 2025 (4), 2009 (3), 2019 (3), 2016 (2), P30CA022453 (2), U01DC019364 (2), U10CA031946 (2), 2004 (1), 2005 (1), 2014 (1), 2015 (1), 2023 (1), K01AG076865 (1), K23AG049181 (1)