37 completed, 9 unknown, 4 recruiting, 3 active not recruiting. 43 Not applicable, 3 Phase 4, 2 Phase 1, 1 Early Phase 1, 1 Phase 2.
Follow Root Canal Infection: new trials by email Literature Review of Root Canal Infection trials Research Report on Root Canal Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Postoperative Pain After Using a Minimally Invasive Reciprocating Single-file System in Mandibular Molars With Symptomatic Irreversible Pulpitis Reciprocating rotary single-file system, Wave One Gold rotary file system - Root Canal Infection | Not applicable | Not yet recruiting | Minia University | 56 | 2026-07-31 | 2026-07-22 |
| Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament - Periapical Periodontitis, Root Canal Infection | Not applicable | Recruiting | Medipol University | 24 | 2025-10-15 | 2026-06-29 |
| Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR 3% Sodium Hypochlorite Irrigation with Ultrasonic Activation, 5.25% Sodium Hypochlorite Irrigation with Ultrasonic Activation - Primary Apical Periodontitis, Root Canal Infection | Not applicable | Completed | Hasanuddin University | 24 | 2025-10-13 | 2026-06-09 |
| Bacterial Profile Changes During Different Sodium Hypochlorite Irrigation Regimens and Calcium Hydroxide Medicament in Root Canal Treatment Root canal treatment with 5.25% sodium hypochlorite irrigation, Root canal treatment with 3% sodium hypochlorite irrigation - Chronic Apical Abscess, Root Canal Infection | Not applicable | Completed | Hasanuddin University | 24 | 2025-10-13 | 2026-06-05 |
| Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth Ultrasonic Activation, 980-nm Diode Laser Activation - Pulp Necrosis, Root Canal Infection | Not applicable | Completed | Hasanuddin University | 16 | 2025-10-13 | 2026-05-26 |
| Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars Lesion sterilization and tissue repair, Conventional pulpectomy - Pulpitis - Irreversible, Pulp Necroses | Active not recruiting | Çanakkale Onsekiz Mart University | 59 | 2025-10-01 | 2026-10-07 | |
| Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment modified endocrown - Root Canal Infection, Tooth Defect | Not applicable | Recruiting | Nanfang Hospital, Southern Medical University | 246 | 2025-08-04 | 2025-10-03 |
| Toluidine Blue-Based Photodynamic Therapy for Antibacterial Activity and Postoperative Pain Toluidine Blue O (0.1 mg/mL), 630-nm LED Light Device, Photodynamic Therapy (PDT) - Root Canal Infection | Not applicable | Active not recruiting | Ataturk University | 50 | 2025-06-01 | 2026-11-13 |
| Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents - Apical Periodontitis, Dental Pulp Necrosis | Not applicable | Recruiting | ESRA DAĞCI | 90 | 2025-05-05 | 2025-07-04 |
| Comparative Analysis of Root Canal Microbiota in Diabetic and Systemically Healthy Patients Root Canal Infection | Completed | Bulent Ecevit University | 39 | 2024-09-02 | 2025-07-02 | |
| Effectiveness of GentleWave System in Endodontic Treatment GentleWave, Conventional Protocol - Pain, Postoperative, Root Canal Infection | Not applicable | Unknown | University of Salamanca | 70 | 2024-08-20 | 2024-08-21 |
| Comparison of Effectiveness of Disinfectants Sodium Hypochlorite, Chlorhexidine - Root Canal Infection | Phase 1 | Completed | Armed Forces Institute of Dentistry, Pakistan | 124 | 2024-03-24 | 2025-02-06 |
| Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria Root canal shaping with One Curve Mini #25/0.4 and passive ultrasonic irrigation, Root canal shaping with One Curve Mini #35/0.4 and passive ultrasonic irrigation - Periapical Periodontitis, Root Canal Infection | Not applicable | Completed | Medipol University | 24 | 2024-02-24 | 2025-06-05 |
| Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion apical shaping size - Root Canal Infection, Periapical Diseases | Completed | Istanbul Medipol University Hospital | 24 | 2024-02-24 | 2026-11-04 | |
| Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide. - Apical Periodontitis, Root Canal Infection | Not applicable | Active not recruiting | National and Kapodistrian University of Athens | 44 | 2023-12-01 | 2025-05-11 |
| Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection Waterlase Express™, BIOLASE®, Sodium Hypochlorite - Endodontic Disease, Root Canal Infection | Not applicable | Terminated | University of Pennsylvania | 56 | 2023-10-11 | 2025-10-09 |
| Sealer-Based Obturation With AH Plus Bioceramic Sealer vs. Warm Vertical Compaction With AH Plus AH Plus Bioceramic Sealer, AH Plus Sealer (resin-based) - Root Canal Infection, Periapical Periodontitis | Not applicable | Completed | Ministry of Health, Kuwait | 156 | 2023-08-07 | 2026-10-09 |
| Calcium Silicate Sealer-based Obturation in Root Canal Retreatment CeraSeal (Calcium Silicate-based Root Canal Sealer) - Root Canal Infection, Periapical Diseases | Completed | Ministry of Health, Kuwait | 136 | 2023-03-05 | 2026-05-26 |
Showing 20 of 58. Sign in to see all of them.
Periapical Periodontitis (14) · Dental Pulp Diseases (11) · Pain, Postoperative (10) · Periapical Diseases (6) · Dental Pulp Necrosis (5) · Tooth, Nonvital (5) · Periapical Abscess (3) · Infections (2) · Pain (2) · Pulpitis (2) · Tooth Discoloration (2) · Bisphosphonate-Associated Osteonecrosis of the Jaw (1) · Bites and Stings (1) · Necrosis (1) · Toothache (1)
Stomatognathic Diseases (33) · Tooth Diseases (22) · Jaw Diseases (19) · Mouth Diseases (19) · Periodontal Diseases (19) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Periodontitis (16) · Periapical Diseases (13) · Dental Pulp Diseases (10) · Neurologic Manifestations (10) · Postoperative Complications (10) · Signs and Symptoms (10) · Pain (8) · Necrosis (6)
Sodium Hypochlorite (8) · Calcium Hydroxide (4) · Edetic Acid (4) · Chlorhexidine (3) · Endodontics (2) · Root Canal Preparation (2) · Anesthesia, Local (1) · Ciprofloxacin (1) · Cone-Beam Computed Tomography (1) · Cryotherapy (1) · Dental Implantation, Endosseous, Endodontic (1) · Etidronic Acid (1) · Ferrosoferric Oxide (1) · Hydrogen Peroxide (1) · Lasers (1)
Istanbul Medipol University Hospital (4) · Ain Shams University (3) · Bulent Ecevit University (3) · Dow University of Health Sciences (3) · Hasanuddin University (3) · Ataturk University (2) · Cairo University (2) · Ege University (2) · Federal University of Pelotas (2) · King's College London (2) · Medipol University (2) · Ministry of Health, Kuwait (2) · Tamil Nadu Dr.M.G.R.Medical University (2) · University of Pennsylvania (2) · Yuzuncu Yil University (2)
Turkey (Türkiye) (17) · United States (6) · Egypt (5) · Pakistan (4) · Indonesia (3) · Brazil (2) · India (2) · Kuwait (2) · United Kingdom (2) · China (1) · Colombia (1) · Greece (1) · Iraq (1) · Lebanon (1) · Oman (1)
Seyda Ersahan, PhD (2) · Abdulkadir Tiftik, DDS, DDS (1) · Ahmed Abdel Rahman Hashem (1) · Ahmed Abdel Rahman Hashem, phd (1) · Ahmed H Ali, Ph.D (1) · Ali G Erdemir (1) · Araib AT Tahir, BDS (1) · Beatrix Zitzy Uniquen Enoch, DDS (1) · Bekir Karabucak, DMD, MS. (1) · Berkant Sezer, Assoc. Prof. (1) · Brett Gilbert, DDS (1) · Fatih Cakici, DDS, PhD (1)
PMID 14651280, PMID 15917679, PMID 18437843, PMID 21238793, PMID 21329812, PMID 21924201, PMID 22403423, PMID 22892736, PMID 24651335, PMID 24908421, PMID 25892512, PMID 27142579, PMID 28483164, PMID 28530469, PMID 29432651, PMID 30981431, PMID 31050927, PMID 31093742, PMID 32553879, PMID 32860137, PMID 3457698, PMID 34958494, PMID 36856848, PMID 41301223, PMID 41350378, PMID 42568232
2016 (1)