65 completed, 20 unknown, 6 recruiting, 5 active not recruiting. 85 Not applicable, 7 Phase 4, 2 Phase 1, 2 Phase 2, 2 Phase 3.
Follow Tooth Discoloration: new trials by email Literature Review of Tooth Discoloration trials Research Report on Tooth Discoloration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Children Acceptance of AgNP Mouthwash Against Chlorhexidine 0.12% and Chlorhexidine .2% Mouthwashs nano silver mouthwash, Chlorhexidine mouthwash (0.12%), Chlorhexidine mouthwash (0.2%) - Teeth Staining, Numbness of the Tongue and Soft Tissue | Not applicable | Not yet recruiting | Cairo University | 93 | 2027-01-01 | 2026-10-21 |
| Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste Nano Bio-Fusion (NBF) Gingival Gel, Placebo Gel, Commercial fluoride toothpaste - Gingivitis, Healthy Adult | Not applicable | Not yet recruiting | King Abdullah University Hospital | 45 | 2026-10-01 | 2026-10-19 |
| A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste - Tooth Discoloration | Not applicable | Recruiting | HALEON | 360 | 2026-09-25 | 2026-10-07 |
| Peroxide Versus Non-Peroxide In-Office Tooth Bleaching peroxide -based in office tooth bleaching, non-peroxide -based in office tooth bleaching - Tooth Discoloration, Tooth Staining | Not applicable | Recruiting | Minia University | 50 | 2026-08-15 | 2026-10-15 |
| Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching Treatment - Discolored Teeth | Not applicable | Not yet recruiting | Cairo University | 38 | 2026-08-01 | 2026-08-18 |
| Comparison of Erythritol Air-Polishing and Conventional Polishing Following Ultrasonic Scaling on the Relapse of Chromogenic Tooth Staining in Children Guided Biofilm Therapy with erythritol, Conventional Polishing - Black Staining | Not applicable | Not yet recruiting | Marmara University | 56 | 2026-07-07 | 2026-07-28 |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 100 | 2026-05-11 | 2026-08-13 |
| Oil Pulling Whitening Mouthwash GuruNanda natural Oil Pulling oral rinse, Therabreath Whitening Mouthwash - Dazzling Mint, GuruNanda water-based non-whitening mouthwash - Healthy Adult Participants, Tooth Stain | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 120 | 2026-05-01 | 2026-06-24 |
| Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia Questionnaires - Dental Diseases | Recruiting | University Hospital, Toulouse | 120 | 2026-04-07 | 2026-05-12 | |
| Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion (Antivet, MDC DENTAL, Zapopan Jalisco México), Opalustre, phosphoric acid 37% and aluminium oxid 50 microns - Teeth Staining | Phase 1 | Recruiting | Misr University for Science and Technology | 60 | 2026-01-10 | 2026-07-16 |
| Guided Biofilm Therapy Versus Conventional Polishing for Tooth Re-Staining Guided Biofilm Therapy, Conventional Polishing - Tooth Stain | Not applicable | Completed | Ataturk University | 34 | 2026-01-05 | 2026-10-14 |
| A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent nano chitosan - Tooth Discoloration | Phase 1 | Enrolling by invitation | Misr University for Science and Technology | 42 | 2025-10-15 | 2025-09-25 |
| Clinical Evaluation of Discoloration Induced by Root Canal Treatment in Vital and Devital Teeth Root Canal Treatment - Tooth Discoloration Following Root Canal Treatment, Tooth Discoloration | Active not recruiting | Marmara University | 52 | 2025-09-16 | 2026-08-27 | |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 109 | 2025-09-11 | 2026-08-11 |
| A Clinical Study to Evaluate the Stain Reduction Efficacy of a Non-Fluoride Tooth Whitening Dentifrice Containing Nano-Hydroxyapatite (nHAP) and a High Cleaning Silica Abrasive System Compared to a Commercial Fluoride Non-Whitening Dentifrice as a Negative Control toothpaste - Teeth Color, Teeth Staining | Not applicable | Completed | Boka LLC | 120 | 2025-09-01 | 2026-08-11 |
| A Comparative Clinical Study Assessing Dentin Thickness and Discoloration in Deep Carious Lesions Treated With Biodentine Alone Versus Diode Laser Pre-treatment Followed by Biodentine Biodentin, Diode laser - Patients With Deep Carious Lesions, Deep Caries Lesion of Pemanent Teeth | Not applicable | Active not recruiting | Misr International University | 48 | 2025-07-30 | 2026-01-22 |
| Clinical Evaluation of Prefabricated Versus 3D-Printed Composite Resin Veneers: in Vivo Study Prefabricated Composite Resin Veneers, 3D-Printed Composite Resin Veneers - Veneer, Composite Restorations | Not applicable | Active not recruiting | Tanta University | 40 | 2025-04-25 | 2026-07-09 |
| Efficacy and Safety Assessment of Experimental Bleaching Agents BLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B - Tooth Discoloration, Dentin Sensitivity | Not applicable | Not yet recruiting | University of Oklahoma | 240 | 2025-03-01 | 2025-01-31 |
| Comparison of Color Measurements of Postgraduate Dental Students Using Different Color Determination Methods Resins, Composite - Tooth Discoloration | Enrolling by invitation | Hacettepe University | 32 | 2025-01-27 | 2025-01-30 | |
| TOOTH DİSCOLORATİON AFTER ROOT CANAL TREATMENT WİTH AH PLUS AND BİOROOT RCS AH Plus Root Canal Sealer, BioRoot RCS Root Canal Sealer - Tooth Discoloration Following Root Canal Treatment | Not applicable | Completed | Recep Tayyip Erdogan University | 63 | 2024-12-15 | 2026-09-30 |
Showing 20 of 105. Sign in to see all of them.
Dentin Sensitivity (12) · Gingivitis (5) · Hypersensitivity (5) · Tooth Fractures (5) · Dental Caries (3) · Dental Plaque (3) · Patient Satisfaction (3) · Periodontitis (3) · Stomatognathic Diseases (3) · Tooth, Nonvital (3) · Diastema (2) · Periodontal Diseases (2) · Alagille Syndrome (1) · Anodontia (1)
Tooth Diseases (105) · Stomatognathic Diseases (102) · Mouth Diseases (8) · Pathological Conditions, Signs and Symptoms (7) · Wounds and Injuries (6) · Behavior (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Gingival Diseases (5) · Immune System Diseases (5) · Infections (5) · Pathologic Processes (5) · Periodontal Diseases (5) · Tooth Injuries (5) · Dental Pulp Diseases (4)
Hydrogen Peroxide (5) · Tooth Bleaching (5) · Toothpastes (4) · Bleaching Agents (3) · Carbamide Peroxide (3) · Dental Prophylaxis (3) · Endodontics (2) · hydrated silica gel-based toothpaste (2) · Calcium Carbonate (1) · Composite Resins (1) · Cosmetics (1) · Diet (1) · Gels (1) · Glutathione (1) · IPS e.max CAD LT (1)
Cairo University (19) · Tanta University (4) · University of Chile (4) · Boka LLC (3) · Ege University (3) · Federal University of Pelotas (3) · Home Skinovations Ltd. (3) · Marmara University (3) · Misr University for Science and Technology (3) · Aristotle University Of Thessaloniki (2) · Cardenal Herrera University (2) · Colgate Palmolive (2) · Dow University of Health Sciences (2) · Fujian Medical University (2) · Glo Science, Inc. (2)
Turkey (Türkiye) (17) · Egypt (15) · United States (13) · Brazil (8) · Spain (5) · Jordan (4) · Chile (3) · Pakistan (3) · China (2) · Italy (2) · Croatia (1) · Dominican Republic (1) · France (1) · Germany (1) · Greece (1)
Hao Yu (2) · Jeffery L Milleman, DDS, MPA (2) · Afsheen Mansoor, PhD (1) · Alessandra Reis, DDS, MS (1) · Anas Abdo, DDS (1) · Andre L Faria-e-Silva, PhD (1) · Ann Spolarich, RDH, PhD (1) · Antonio Pacino, D.D.S. (1) · Arif Bolaca, Dr (1) · Asmaa Yassen, ph degree (1) · Associate Prof (1) · Bennett T Amaechi, BDS, MS, PhD (1) · David Herrera, Prof. (1)
PMID 37138297, PMID 10507207, PMID 12793212, PMID 15853099, PMID 18722039, PMID 20122985, PMID 20621154, PMID 21055582, PMID 21085810, PMID 21724070, PMID 22695211, PMID 24352384, PMID 25408598, PMID 25646134, PMID 29504880, PMID 29977603, PMID 30132252, PMID 30537968, PMID 30541995, PMID 31181242, PMID 31289971, PMID 31633462, PMID 32169479, PMID 32354432, PMID 32917192, PMID 33098228, PMID 33188588, PMID 33336852, PMID 33491927, PMID 33512114, PMID 33825424, PMID 33883353, PMID 34145478, PMID 34911896, PMID 34973707, PMID 35019018, PMID 35266059, PMID 35793984, PMID 36398065, PMID 36433113, PMID 36445467, PMID 36478098, PMID 36709985, PMID 37443061, PMID 37888157, PMID 38057996, PMID 38303586, PMID 38349843, PMID 38393754, PMID 38541534
2005 (1)