120 completed, 60 unknown, 15 terminated, 12 recruiting. 155 Not applicable, 21 Phase 2, 17 Phase 3, 15 Phase 1, 15 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs) GentleMax Pro (with skin cooling), GentleMax Pro (without skin cooling) - Neurofibromatosis 1 (NF1), Neurofibromatosis Type I | Not applicable | Suspended | Massachusetts General Hospital | 10 | 2027-01-01 | 2026-06-04 |
| Maximizing Laser Therapy Success for Port-Wine Birthmarks in Pediatric Patients Pulse Dye laser, Pulse Dye Laser (PDL) pulse width stacking, Pulse Dye Laser (PDL) followed by Nd:YAG (Neodymium-doped Yttrium Aluminum Garnet laser) laser. - Port Wine Stains | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 200 | 2026-07-01 | 2026-06-05 |
| Polidocanol Foam With or Without Transdermal Laser in Varicose Veins Polidocanol foam sclerotherapy, Transdermal Nd:YAG 1064 nm laser - Varicose Veins | Not applicable | Recruiting | Hospital Universitario Pedro Ernesto | 102 | 2026-03-24 | 2026-05-05 |
| Efficacy of Therapeutic Percutaneous Electrolysis Simple vs Multiple vs Laser Therapy in Supraspinatus Tendinopathy. Simple electrolysis percutaneous, Multifiliar Electrolysis percutaneus, Laser - Tendinopathy | Not applicable | Completed | Universidad Pontificia de Salamanca | 90 | 2026-01-11 | 2026-10-22 |
| Efficacy of Therapeutic Percutaneous Electrolysis Simple vs Multifiliar Therapy in Supraspinatus Tendinopathy. Electrolysis percutaneus, Laser - Tendinopathy | Not applicable | Recruiting | Universidad Pontificia de Salamanca | 40 | 2026-01-10 | 2026-07-07 |
| CLINICAL INVESTIGATION TO EVALUATE THE EFFICACY AND SAFETY OF EPILADY PROTOTYPE DEVICE FOLLOWED BY APPLICATION OF A TOPICAL FORMULA ON DEPIGMENTATION OF LENTIGO SPOTS LASER, LASER AND ACTIVE FORMULA - Solar Lentigo | Not applicable | Not yet recruiting | Cosmetique Active International | 44 | 2026-01-07 | 2025-11-20 |
| Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients Er: YAG laser - Hidradenitis Suppurativa, Scarring | Not applicable | Withdrawn | Montefiore Medical Center | 2026-01-01 | 2025-12-17 | |
| Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause Topical estrogen therapy based on estriol (E3), Active Er:YAG Laser, Sham Er:YAG laser (minimal fluence) - Genitourinary Syndrome of Menopause | Not applicable | Recruiting | University of Nove de Julho | 60 | 2025-12-10 | 2026-04-23 |
| Effect of Diode Laser and 20% Benzocaine Anesthetic Gel on Pain Reduction Following Tooth Separation With Elastomeric Separators in Fixed Orthodontic Patients: A Randomized Trial in Karachi-Pakistan Laser, Benzocaine 20% - We Are Not Studying a Disease or Condition, Pain Reduction | Not applicable | Active not recruiting | Dow University of Health Sciences | 72 | 2025-12-01 | 2026-04-30 |
| Comparing Three Surgical Techniques for the Treatment of Transsphincteric Perianal Fistula: (1) Traditional Fistulotomy (Lay Open), (2) Ligation of the Intersphincteric Tract (LIFT) With Adjunctive Endo Fistula Laser Ablation, and (3) Open LIFT Procedure Followed by LASER fistula lay open, LIFT plus LASER, open LIFT plus LASER - Perianal Fistula | Not applicable | Not yet recruiting | Alexandria University | 90 | 2025-11-20 | 2025-11-21 |
| Testing the Efficacy of Photobiomodulation Therapy and Hyaluronic Acid Gel on Post-surgical Healing After Gingivectomy Gengigel, LASER - Gingival Hyperplasia, Gingival Hypertrophy | Early Phase 1 | Enrolling by invitation | Beirut Arab University | 38 | 2025-11-11 | 2025-11-14 |
| Comparison of Effectiveness of Low Dose Laser and Transcutaneous Electrical Stimulation in Hemiplegic Shoulder Low Dose Laser, TENS, Conventional physical therapy - Hemiplegic Shoulder Pain | Not applicable | Completed | Ankara Etlik City Hospital | 45 | 2025-09-24 | 2026-10-30 |
| Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN) Acupuncture, myofascial therapy, microcurrent therapy - Chronic Pain | Not applicable | Recruiting | David Moss | 125 | 2025-08-04 | 2026-08-21 |
| Antimicrobial Impact of Various RC Final Irrigation Activation Techniques manual dynamic agitaion, ultrasonic activation, xp-endo finisher - Root Canal Final Irrigation Activation Techniques | Not applicable | Not yet recruiting | Tanta University | 40 | 2025-08-01 | 2025-07-09 |
| Comparative Effects of Laser and Extracorpeal Shock Wave in Patients With Achilles Tendinopathy. Laser, Extracorporeal shock wave therapy protocol - Achilles Tendinopathy | Not applicable | Not yet recruiting | Riphah International University | 44 | 2025-07-24 | 2025-07-07 |
| Evaluation of the Efficacy and Safety of Lactobacillus Crispatus M247 (Crispact®) With Vaginal Laser Therapy in Menopausal Women With Atrophic Vulvovaginitis (VVA) Monnalisa Touch® Laser Therapy, Monnalisa Touch® Laser Therapy + Lactobacillus crispatus M247 (Crispact®) - Atrophic Vulvovaginitis | Not applicable | Completed | Liaquat University of Medical & Health Sciences | 75 | 2025-07-01 | 2026-01-06 |
| Elhafez Technique Combined With Dynamic Scapulohumeral Mobilization in Shoulder Adhesive Capsulitis Laser and ultrasound - Adhesive Capsulitis of the Shoulder | Not applicable | Suspended | Haytham M Elhafez | 90 | 2025-04-09 | 2026-05-18 |
| Transcutaneous Laser Therapy in Chronic Kidney Disease Laser, Red Light - Chronic Kidney Disease(CKD) | Not applicable | Not yet recruiting | National Cheng-Kung University Hospital | 120 | 2025-03-17 | 2025-03-18 |
| Non-Surgical Laser Treatment for Peri-Implantitis: Er:YAG & Diode Laser Ultrasonic Scalers with EMS PI tip and Saline Irrigation, Er:YAG (2940nm) and Diode (808nm) Laser - Peri-Implantitis | Not applicable | Completed | Aristotle University Of Thessaloniki | 40 | 2025-01-30 | 2026-01-27 |
| Diode Laser as an Adjunct to Professional Mechanical Plaque Removal Professional mechanical plaque removal and Laser, Professional mechanical plaque removal - Periodontitis, Pocket, Periodontal | Not applicable | Active not recruiting | University of Sulaimani | 40 | 2025-01-01 | 2026-05-04 |
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Pain (13) · Diabetic Retinopathy (7) · Cicatrix (6) · Macular Edema (6) · Edema (5) · Dentin Sensitivity (4) · Glaucoma (4) · Glaucoma, Open-Angle (4) · Onychomycosis (4) · Osteoarthritis (4) · Retinal Detachment (4) · Vision Disorders (4) · Alopecia (3) · Breast Neoplasms (3) · Chronic Pain (3)
Cairo University (10) · University of Nove de Julho (6) · Jaeb Center for Health Research (5) · Mahidol University (4) · Universidade Federal de Sao Carlos (4) · University of Sao Paulo (4) · University of Sao Paulo General Hospital (4) · Assiut University (3) · Cynosure, Inc. (3) · Federal University of São Paulo (3) · Novartis Pharmaceuticals (3) · Universidade Federal do Para (3) · University of Malaya (3) · Wroclaw Medical University (3) · Alexandria University (2)
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Nivaldo A Parizotto, PhD (3) · Gang Wang, Prof (2) · Kenneth C Fong, FRCOphth (2) · Murad Alam, MD (2) · Patricia Krantz (2) · Rajeev Muni, FRSCS (2) · Vanderlei S Bagnato, PhD (2) · Adam Donne (1) · Ahmed R. EL-Nahas, MD (1) · Akito Hirakata, MD (1) · Akmal Saad, professor (1) · Alberto Calligaro, MD, PhD (1)
PMID 21571677, PMID 25408141, PMID 27288517, PMID 30908578, PMID 34099238, PMID 36583575, PMID 40709601, PMID 10796403, PMID 11130084, PMID 11896772, PMID 12513918, PMID 12559262, PMID 12700842, PMID 12930332, PMID 14666667, PMID 15216537, PMID 15704096, PMID 15841638, PMID 15895289, PMID 16091763, PMID 16582131, PMID 16616270, PMID 16985862, PMID 17136582, PMID 17270603, PMID 17544778, PMID 17629805, PMID 17765429, PMID 17902519, PMID 18662829, PMID 18698292, PMID 18853213, PMID 19273785, PMID 19347224, PMID 19364757, PMID 19506791, PMID 19603309, PMID 19708800, PMID 19732015, PMID 19748212, PMID 19891690, PMID 19898182, PMID 19913903, PMID 20008708, PMID 20008710, PMID 20122739, PMID 20189016, PMID 20427088, PMID 20666669, PMID 20925995
U10EY014229 (4), U10EY014231 (4), U10EY018817 (4), 2015 (2), 2016 (1), UG1EY011751 (1)