6 completed, 4 unknown, 2 active not recruiting, 1 not yet recruiting. 6 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Unknown 3, Active not recruiting 1, Completed 1, Not yet recruiting 1 |
| Phase 3 | 1 | Active not recruiting 1 |
Follow Bisphosphonate-Associated Osteonecrosis of the Jaw: new trials by email Literature Review of Bisphosphonate-Associated Osteonecrosis of the Jaw trials Research Report on Bisphosphonate-Associated Osteonecrosis of the Jaw
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Oxygen Therapy for BRONJ Topical Blue®m application, PRF membrane placement - Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen | Not applicable | Active not recruiting | Mansoura University | 36 | 2026-04-01 | 2026-07-24 |
| Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ Piezoelectric surgery, Conventional surgery - Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 34 | 2025-12-01 | 2025-09-22 |
| Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF - Oral Mucositis, Osteoradionecrosis | Not applicable | Completed | University of Santiago de Compostela | 60 | 2021-02-10 | 2023-11-29 |
| Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs Dental management - Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw | Recruiting | Catholic University of the Sacred Heart | 126 | 2021-01-01 | 2024-06-20 | |
| Initial Management of MRONJ Stages I and II, a Clinical Trial With Detection of Salivary Biomarkers Surgical treatment - Osteonecrosis of the Jaw, Bisphosphonate Induced, Osteonecrosis of the Jaw, Bisphosphonate Related | Not applicable | Unknown | Fundació d'investigació Sanitària de les Illes Balears | 50 | 2020-11-01 | 2021-02-16 |
| Efficacy and Safety on the Use of Bisphosphonates in Paediatrics No intervention, observational study - Bone Fragile, Bisphosphonate-Associated Osteonecrosis | Completed | Centre Hospitalier Universitaire de Nīmes | 99 | 2018-10-31 | 2019-07-09 | |
| Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ) Pentoxifylline, Placebo, Tocopherol - Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw | Phase 3 | Active not recruiting | University of Washington | 100 | 2018-04-01 | 2026-04-29 |
| Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones) Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related | Completed | Akdeniz University | 102 | 2018-01-01 | 2025-04-09 | |
| Medication-related Osteonecrosis of the Jaw (MRONJ) Registry Conservative treatment, Surgical treatment, Adjuvant non-surgical treatment - Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw | Unknown | AO Clinical Investigation and Publishing Documentation | 518 | 2017-08-14 | 2024-03-20 | |
| Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine), atraumatic extraction - Bisphosphonate-Associated Osteonecrosis of the Jaw | Not applicable | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 100 | 2014-01-01 | 2014-07-23 |
| Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use Osteoporosis, With or Without Treatment, Bisphosphonate Treatment | Completed | University of Pennsylvania | 314 | 2012-04-13 | 2023-01-13 | |
| Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay BRONJ - Bisphosphonate-related Osteonecrosis of the Jaw | Not applicable | Unknown | Micromedic Technologies Ltd | 150 | 2012-01-01 | 2014-08-18 |
| Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer Bone Diseases, Metastases | Completed | University of Michigan | 271 | 2010-08-01 | 2014-12-02 | |
| Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy Root canal treatment - Root Canal Infection, Bisphosphonate-Associated Osteonecrosis | Completed | University of Bologna | 111 | 2009-01-07 | 2020-05-27 |
Osteonecrosis (4) · Bone Diseases (1) · Head and Neck Neoplasms (1) · Mouth Neoplasms (1) · Neoplasm Metastasis (1) · Osteoporosis (1) · Osteoradionecrosis (1) · Periapical Abscess (1) · Stomatitis (1) · Tooth, Nonvital (1) · Xerostomia (1)
Jaw Diseases (14) · Musculoskeletal Diseases (14) · Necrosis (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Stomatognathic Diseases (14) · Bone Diseases (13) · Osteonecrosis (10) · Mouth Diseases (2) · Neoplasms (2) · Abscess (1) · Bone Diseases, Metabolic (1) · Dental Pulp Diseases (1) · Infections (1) · Metabolic Diseases (1)
Surgical Procedures, Operative (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Anti-Bacterial Agents (1) · Clindamycin (1) · Conservative Treatment (1) · Observation (1) · Pentoxifylline (1) · Practice Management, Dental (1) · Tocopherols (1) · Tooth Extraction (1) · Vitamin E (1)
AO Clinical Investigation and Publishing Documentation (1) · Akdeniz University (1) · Catholic University of the Sacred Heart (1) · Centre Hospitalier Universitaire de Nīmes (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Fundació d'investigació Sanitària de les Illes Balears (1) · Mansoura University (1) · Micromedic Technologies Ltd (1) · University of Bologna (1) · University of Michigan (1) · University of Pennsylvania (1) · University of Santiago de Compostela (1) · University of Washington (1)
United States (4) · Spain (3) · Italy (2) · Belgium (1) · Egypt (1) · Finland (1) · France (1) · Germany (1) · Israel (1) · Netherlands (1) · Qatar (1) · Romania (1) · Slovenia (1) · South Korea (1) · Switzerland (1)
Annamarie D Horan, PhD (1) · Carlo Lajolo, MD,DDS (1) · Catherine Van Poznak, MD (1) · Jasjit Dillon, DDS, MBBS (1) · Noam Yarom, Dr. (1) · Risto Kontio, MD DDS PhD (1) · Samir Mehta, MD (1)
PMID 35866376, PMID 24908421, PMID 29432651, PMID 40618141, PMID 41327109
K23DE020197 (1)