13 completed. 13 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Phase 2 | 4 | Completed 4 |
Follow Respiratory Failure: new trials by email Literature Review of Respiratory Failure trials Research Report on Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients Cuff Leak Test, Dexamethasone 4mg - Respiratory Failure | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 100 | 2023-04-05 | 2025-03-10 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Reduced Anticoagulation Targets in ECLS (RATE) Heparin, LMWH - Heart Failure, Respiratory Failure | Phase 3 | Completed | University Medical Center Groningen | 330 | 2020-10-01 | 2025-05-02 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Self-management of Sedative Therapy by Ventilated Patients Dexmedetomidine - Critical Illness, Anxiety | Phase 2 / Phase 3 | Completed | Mayo Clinic | 161 | 2016-11-01 | 2025-10-02 |
| Astral VAPS AutoEPAP Clinical Trial Astral - Upper Airway Obstruction, Respiratory Insufficiency | Phase 3 | Completed | ResMed | 42 | 2016-04-15 | 2019-07-26 |
| Heart And Lung Failure - Pediatric INsulin Titration Trial Insulin - Heart Failure, Respiratory Failure | Phase 3 | Completed | Boston Children's Hospital | 713 | 2012-04-01 | 2022-07-25 |
| Intellivent Versus Conventional Ventilation Intellivent; automatic mode implemented on a S1 ventilator - Respiratory Failure, Self Efficacy | Phase 3 | Completed | Hamilton Medical AG | 80 | 2011-02-01 | 2012-12-06 |
| Donor Simvastatin Treatment in Organ Transplantation Simvastatin 80mg, Control Rx - Heart Failure, Respiratory Failure | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 84 | 2010-06-01 | 2017-09-19 |
| Early Percutaneous Tracheostomy for Cardiac Surgery (ETOC) Dilatational Percutaneous tracheostomy - Respiratory Failure, Cardiovascular Surgery | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 212 | 2006-07-01 | 2009-12-03 |
| Comparison Between IMV and SIMV/PS for Ventilatory Support of Children: a Randomized Clinical Trial Intermittent mandatory ventilation (IMV) and synchronous IMV - Respiratory Failure | Phase 3 | Completed | UPECLIN HC FM Botucatu Unesp | 70 | 2005-10-01 | 2008-07-02 |
| Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP) silver salts coated endotracheal tube, uncoated endotracheal tube - Respiratory Failure | Phase 3 | Completed | C. R. Bard | 2003 | 2002-11-01 | 2017-01-18 |
Respiratory Insufficiency (13) · Heart Failure (3) · Respiratory Aspiration (2) · Airway Obstruction (1) · Anxiety Disorders (1) · COVID-19 (1) · Critical Illness (1) · Healthcare-Associated Pneumonia (1) · Hemorrhage (1) · Hypotension (1) · Insulin Resistance (1) · Laryngeal Edema (1) · Liver Failure (1) · Pneumonia, Ventilator-Associated (1) · Pneumonia, Viral (1)
Respiration Disorders (13) · Respiratory Tract Diseases (13) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Cardiovascular Diseases (4) · Heart Diseases (3) · Infections (3) · Lung Diseases (3) · Pneumonia (3) · Respiratory Tract Infections (3) · Vascular Diseases (3) · Disease Attributes (2) · Virus Diseases (2) · Behavior (1) · Coronaviridae Infections (1)
Azithromycin (1) · Dexamethasone (1) · Dexmedetomidine (1) · Enoxaparin (1) · Heparin (1) · Heparin, Low-Molecular-Weight (1) · Hydroxychloroquine (1) · Insulin (1) · Mefloquine (1) · Nadroparin (1) · Norepinephrine (1) · Plasma-lyte 148 (1) · Plasmalyte A (1) · Ringer's Lactate (1) · Saline Solution (1)
Assistance Publique - Hôpitaux de Paris (1) · Australian National University (1) · Boston Children's Hospital (1) · Burnasyan Federal Medical Biophysical Center (1) · C. R. Bard (1) · Hamilton Medical AG (1) · Helsinki University Central Hospital (1) · Mayo Clinic (1) · ResMed (1) · St. Joseph's Healthcare Hamilton (1) · UPECLIN HC FM Botucatu Unesp (1) · University Medical Center Groningen (1) · Wright State University (1)
United States (7) · Canada (2) · Australia (1) · Belgium (1) · Brazil (1) · Finland (1) · France (1) · Kuwait (1) · Netherlands (1) · Russia (1)
Dr. Kimberley Lewis, MD (1) · Frank MP van Haren, MD, PhD (1) · Jose R Fioretto, MD, PhD (1) · Karl B Lemstrom, MD, PhD (1) · Linda L Chlan, RN, PhD (1) · Lisa Wolfe, MD (1) · Marin H Kollef, MD (1) · Matthew Koroscil, MD (1) · Michael SD Agus, MD (1) · Tatiana Astrelina, MD PhD,DSc. (1) · Vinay M Nadkarni, MD (1) · W.M. van den Bergh, PhD, MD (1) · Yonatan Dollin, DO (1)
PMID 18714060, PMID 18989547, PMID 20302428, PMID 21403073, PMID 28118549, PMID 31012225, PMID 31120585, PMID 31352795, PMID 31577692, PMID 31910992, PMID 32740181, PMID 33932465, PMID 35578271, PMID 36656551, PMID 37526194, PMID 37693502, PMID 38066613, PMID 39907523, PMID 40087802, PMID 40537229, PMID 41527181, PMID 42413523
2019 (1), R01HL130881 (1), U01HL107681 (1)