7 completed, 3 unknown, 1 active not recruiting, 1 terminated. 5 Phase 3, 3 Phase 4, 1 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Phase 4 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Active not recruiting 1 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow Plasma-lyte 148: new trials by email Literature Review of Plasma-lyte 148 trials Research Report on Plasma-lyte 148
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis Plasma-Lyte 148, 0.9% sodium chloride - Diabetic Ketoacidosis | Phase 3 | Completed | The George Institute | 547 | 2024-03-14 | 2026-10-05 |
| Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group) - Hypotension During Surgery | Phase 4 | Terminated | Algemeen Ziekenhuis Maria Middelares | 41 | 2023-11-23 | 2026-10-28 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Lactated Ringer, Normal Saline, Plasma-lyte - Shock, Septic | Phase 3 | Completed | Children's Hospital of Philadelphia | 9041 | 2020-08-25 | 2026-03-05 |
| Balanced Crystalloids in Postpartum Hemorrhage Lactate Ringer, Plasma-lyte - Postpartum Hemorrhage | Unknown | Fundación Santa Fe de Bogota | 40 | 2019-01-25 | 2019-02-04 | |
| Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) Human umbilical cord derived CD362 enriched MSCs, Placebo (Plasma-Lyte 148) - Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Active not recruiting | Belfast Health and Social Care Trust | 129 | 2019-01-07 | 2025-09-08 |
| Better Evidence for Selecting Transplant Fluids Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP - End Stage Kidney Disease, Delayed Graft Function | Phase 3 | Completed | The University of Queensland | 808 | 2018-01-26 | 2024-10-15 |
| Plasma-Lyte 148® versUs Saline Study Plasma-Lyte 148®, 0.9% sodium chloride - Hypovolemia | Phase 4 | Completed | The George Institute | 5037 | 2017-09-01 | 2023-08-08 |
| Balanced Solution Versus Saline in Intensive Care Study Plasma-Lyte, Saline 0.9%, Slow infusion speed - Critical Illness, Acute Kidney Injury | Phase 3 | Completed | Hospital do Coracao | 11075 | 2017-05-27 | 2021-04-19 |
| Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery Normal saline, Balanced fluid - Benign Neoplasms, Vascular Malformations, Brain | Unknown | Clinical Hospital Centre Zagreb | 120 | 2017-03-23 | 2019-04-18 | |
| Decision Support for Intraoperative Low Blood Pressure Attending real-time decision support, In-room real-time decision support, Attending feedback emails - Hypotension | Not applicable | Completed | Vanderbilt University Medical Center | 22435 | 2017-01-05 | 2019-05-16 |
| 0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis Plasma-lyte, 0,9% saline - Nephrotoxicity | Phase 4 | Unknown | Regional Hospital Holstebro | 40 | 2015-03-01 | 2015-08-19 |
Hypotension (3) · Acute Kidney Injury (2) · Critical Illness (2) · Shock (2) · COVID-19 (1) · Central Nervous System Vascular Malformations (1) · Delayed Graft Function (1) · Diabetic Ketoacidosis (1) · Hypovolemia (1) · Kidney Failure, Chronic (1) · Neoplasms (1) · Postpartum Hemorrhage (1) · Respiratory Distress Syndrome (1) · Respiratory Insufficiency (1) · Sepsis (1)
The George Institute (2) · Algemeen Ziekenhuis Maria Middelares (1) · Belfast Health and Social Care Trust (1) · Children's Hospital of Philadelphia (1) · Clinical Hospital Centre Zagreb (1) · Fundación Santa Fe de Bogota (1) · Hospital do Coracao (1) · Regional Hospital Holstebro (1) · The University of Queensland (1) · Vanderbilt University Medical Center (1) · Wright State University (1)
Australia (3) · United States (3) · New Zealand (2) · Belgium (1) · Brazil (1) · Colombia (1) · Croatia (1) · Denmark (1) · United Kingdom (1)
Alexandre B Cavalcanti, MD, PhD (1) · Danny F McAuley, Professor (1) · Erling B Perdersen, MD, DMSc (1) · Fernando G Zampieri, MD (1) · Fran Balamuth, MD PhD MSCE (1) · Jesper N Bech, MD, PhD (1) · Jonathan P Wanderer, MD, MPhil (1) · Leopoldo E Ferrer, M.D. (1) · Matthew Koroscil, MD (1) · Michael Collins, MBChB,FRACP,PhD (1) · Natasa Kovac, M.D. (1) · Nilton Brandao, MD, PhD (1)
PMID 28651514, PMID 32450917, PMID 32493473, PMID 33771116, PMID 34375394, PMID 34547081, PMID 34742327, PMID 34746723, PMID 35041780, PMID 35042554, PMID 35349397, PMID 35562778, PMID 35843046, PMID 36735931, PMID 36888820, PMID 37154608, PMID 37343576, PMID 42028918
R01HD101528 (1)