21 completed, 6 unknown, 3 terminated, 1 recruiting. 32 Phase 2, 6 Phase 3, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 32 | Completed 21, Unknown 6, Terminated 3, Recruiting 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 1 | 5 | Completed 4, Withdrawn 1 |
Follow Respiratory Failure: new trials by email Literature Review of Respiratory Failure trials Research Report on Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients Esophageal pressure-guided PEEP titration, Standard care PEEP management - Respiratory Failure | Phase 2 | Recruiting | University of Alberta | 30 | 2026-02-05 | 2026-04-13 |
| Sedation vs No Sedation in Mechanically Ventilated COPD Patients Midalozam - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Completed | Al-Azhar University | 100 | 2025-04-14 | 2026-06-02 |
| MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients MRG-001 (Low-dose), MRG-001 (High-dose), Placebo - Acute Respiratory Distress Syndrome, Respiratory Failure | Phase 2 | Unknown | MedRegen LLC | 60 | 2024-12-01 | 2024-08-23 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial Angiotensin 1-7, Placebos - Coronavirus, Respiratory Failure | Phase 2 / Phase 3 | Unknown | Erasme University Hospital | 60 | 2021-12-30 | 2021-08-02 |
| Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature) - Acute Respiratory Distress Syndrome, Critical Illness | Phase 2 | Completed | Massachusetts General Hospital | 488 | 2021-10-13 | 2024-09-27 |
| Furosemide as Supportive Therapy for COVID-19 Respiratory Failure Nebulized Furosemide, Nebulized Saline - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Terminated | Dr. John Muscedere | 40 | 2021-04-16 | 2023-12-11 |
| Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS Rapamycin, Placebo - Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure | Phase 1 / Phase 2 | Withdrawn | The University of Texas Health Science Center at San Antonio | 2021-04-01 | 2021-06-01 | |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Tenecteplase in Patients With COVID-19 Tenecteplase, Placebo - COVID-19, Respiratory Failure | Phase 2 | Completed | Hooman Poor | 13 | 2020-09-25 | 2023-04-06 |
| Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation Convalescent Plasma, Standard of Care - Covid19, Mechanical Ventilation Complication | Phase 2 | Completed | University of Liege | 475 | 2020-09-11 | 2024-10-29 |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| High Flow Nasal Cannula Oxygen During Sedation for Video-assisted Thoracoscopic Surgery High flow nasal cannula, CONTROL - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Unknown | Alexandria University | 60 | 2020-08-01 | 2020-08-20 |
| Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Pemziviptadil (PB1046), Low Dose (10 mg) Control - Acute Respiratory Distress Syndrome, Coronavirus | Phase 2 | Terminated | PhaseBio Pharmaceuticals Inc. | 54 | 2020-07-15 | 2020-12-11 |
| Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure Iloprost, Isotonic saline - COVID-19, Respiratory Failure | Phase 2 | Completed | Pär Johansson | 80 | 2020-06-15 | 2024-05-07 |
| Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection Alteplase 50 MG [Activase] - Severe Acute Respiratory Syndrome, Respiratory Failure | Phase 2 | Completed | Denver Health and Hospital Authority | 50 | 2020-05-14 | 2022-01-20 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 Tirofiban Injection, Clopidogrel, Acetylsalicylic acid - Pneumonia, Viral, Corona Virus Infection | Phase 2 | Completed | University of Milan | 5 | 2020-04-06 | 2020-04-29 |
| Self-management of Sedative Therapy by Ventilated Patients Dexmedetomidine - Critical Illness, Anxiety | Phase 2 / Phase 3 | Completed | Mayo Clinic | 161 | 2016-11-01 | 2025-10-02 |
| CYCLE Pilot Randomized Trial In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy - Intensive Care Unit Acquired Weakness, Critical Care | Phase 2 | Completed | McMaster University | 113 | 2015-03-01 | 2022-12-05 |
Showing 20 of 32. Sign in to see all of them.
Respiratory Insufficiency (32) · COVID-19 (9) · Respiratory Distress Syndrome (8) · Coronavirus Infections (5) · Critical Illness (5) · Acute Lung Injury (4) · Cytokine Release Syndrome (2) · Heart Failure (2) · Pneumonia (2) · Pneumonia, Viral (2) · Pulmonary Disease, Chronic Obstructive (2) · Severe Acute Respiratory Syndrome (2) · Anxiety Disorders (1) · Cardiovascular Diseases (1) · Cross Infection (1)
Respiration Disorders (32) · Respiratory Tract Diseases (31) · Lung Diseases (19) · Infections (14) · Pathological Conditions, Signs and Symptoms (12) · Virus Diseases (12) · Coronaviridae Infections (11) · Nidovirales Infections (11) · Pathologic Processes (11) · RNA Virus Infections (11) · Respiratory Tract Infections (10) · Disease Attributes (8) · Pneumonia (8) · Pneumonia, Viral (8) · Coronavirus Infections (6)
Sodium Chloride (2) · angiotensin I (1-7) (2) · Aspirin (1) · Azithromycin (1) · Clopidogrel (1) · Dexmedetomidine (1) · Etomidate (1) · Fondaparinux (1) · Ganciclovir (1) · Glucose (1) · Hydroxychloroquine (1) · Iloprost (1) · Mefloquine (1) · Midazolam (1) · Respiration, Artificial (1)
Erasme University Hospital (2) · Al-Azhar University (1) · Alexandria University (1) · Australian National University (1) · Beth Israel Deaconess Medical Center (1) · Burnasyan Federal Medical Biophysical Center (1) · Chang Gung Memorial Hospital (1) · Denver Health and Hospital Authority (1) · Dr. John Muscedere (1) · Emory University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fred Hutchinson Cancer Center (1) · Helsinki University Central Hospital (1) · Hooman Poor (1) · Intermountain Health Care, Inc. (1)
United States (17) · Canada (4) · Egypt (2) · Australia (1) · Belgium (1) · Brazil (1) · Denmark (1) · Finland (1) · Germany (1) · Italy (1) · Russia (1) · Taiwan (1)
Ajit Limaye, MD (1) · Ana Martins Valle (1) · Anders Perner, MD, PhD (1) · Boyd Taylor Thompson, MD (1) · Christian Putensen, MD, Prof (1) · Dean L Kellogg, MD, PhD (1) · Eliotte Hirshberg, MD (1) · Ernest E Moore, MD (1) · Filippo Annoni (1) · Filippo Annoni, MD (1) · Frank MP van Haren, MD, PhD (1) · Gordon R Bernard, MD (1) · Greg Martin, MD, MSc (1) · Hooman Poor, MD (1) · J Mocco, MD (1)
PMID 27059469, PMID 27419080, PMID 28829877, PMID 30558653, PMID 30956804, PMID 31352795, PMID 31455384, PMID 31741746, PMID 32838109, PMID 32847626, PMID 33287790, PMID 33331622, PMID 33502773, PMID 34592318, PMID 35244208, PMID 37355270, PMID 37633275, PMID 37889107, PMID 38762798, PMID 38865147, PMID 39231898, PMID 39317833, PMID 39432177, PMID 39467285, PMID 41788496
R01HL130881 (1), U01HL102235 (1), U01HL102547 (1)