31 completed, 3 terminated, 2 unknown, 1 not yet recruiting. 10 Phase 2, 10 Phase 3, 8 Not applicable, 8 Phase 1, 8 Phase 4.
Follow Mefloquine: new trials by email Literature Review of Mefloquine trials Research Report on Mefloquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repurposing Mefloquine for Pancreatic Cancer Treatment Mefloquine, Modified FOLFIRINOX, gemcitabine and nab paclitaxel - Pancreatic Ductal Adenocarcinoma | Phase 1 | Not yet recruiting | University of Florida | 36 | 2026-11-01 | 2026-10-15 |
| Efficacy of Mefloquine as Prophylaxis Against COVID-19: A Placebo-control, Randomized Clinical Trial Mefloquine as a prophylaxis against SARS-Cov-2 infection in household contacts of COVID 19 confirmed cases - Covid19 | Phase 2 / Phase 3 | Completed | Helwan University | 137 | 2021-03-28 | 2023-03-06 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children Praziquantel, Artesunate + Mefloquine - Schistosoma Haematobium, Schistosoma Mansoni | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 726 | 2019-10-14 | 2021-04-05 |
| Safety and Efficacy of NF135 CPS Immunization CPS-immunization, malaria challenge infection, P. falciparum NF135.C10, malaria challenge infection, P. falciparum NF54 - Malaria,Falciparum, Controlled Human Malaria Infection | Not applicable | Terminated | Radboud University Medical Center | 43 | 2019-04-01 | 2023-05-26 |
| A Pharmacodynamics, Safety, and Pharmacokinetics Study of THN201 Versus Donepezil in Healthy Male Volunteers THN 201, Donepezil, Placebo - Cognitive Impairment, Alzheimer Disease | Phase 1 | Completed | Theranexus | 152 | 2018-09-27 | 2020-01-22 |
| Malaria Elimination Pilot Study in Military Forces in Cambodia DHA-PIP, Primaquine, Artesunate + Mefloquine - Malaria, Parasitic Diseases | Phase 4 | Unknown | Armed Forces Research Institute of Medical Sciences, Thailand | 1050 | 2016-01-01 | 2021-03-02 |
| Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia Dihydroartemisinin-piperaquine (DHA-PPQ), Mefloquine (MQ) - Acute Falciparum Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 216 | 2015-11-20 | 2019-10-10 |
| A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients Mefloquine, Sulphadoxine-Pyrimethamine - Malaria in Pregnant HIV + Patients | Phase 1 | Completed | ORIYOMI OMOTOYOSI AKINYOTU | 142 | 2015-09-01 | 2017-12-11 |
| Pharmacokinetic and Pharmacodynamic Study of Mefloquine and Dihydroartemisinin-Piperaquine in Healthy Subjects Mefloquine and Dihydroartemisinin-piperaquine, Wash-out period, Mefloquine - Healthy | Phase 4 | Completed | University of Oxford | 16 | 2015-01-01 | 2015-11-03 |
| Assessment of Artesunate/Mefloquine in the Peruvian Amazon Artesunate, Mefloquine - Malaria, Falciparum | Phase 4 | Completed | Instituto Nacional de Salud. Peru | 45 | 2014-06-18 | 2021-04-29 |
| Harmonized AS/MQ Efficacy Study - Thailand Artesunate/mefloquine (AS/MQ) - Malaria | Phase 4 | Completed | Armed Forces Research Institute of Medical Sciences, Thailand | 48 | 2013-10-01 | 2016-01-25 |
| In Vivo and In Vitro Efficacy of Artemisinin Combination Therapy Artesunate, Artemether Lumefantrine, Mefloquine - Malaria | Phase 4 | Completed | Global Emerging Infections Surveillance and Response System | 118 | 2013-06-01 | 2017-05-11 |
| Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy Mefloquine, Memantine Hydrochloride, Metformin Hydrochloride - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 144 | 2011-09-14 | 2025-05-07 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
| Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia Artemisone/Mefloquine (AmiM3), Artesunate - Uncomplicated Falciparum Malaria | Phase 2 / Phase 3 | Withdrawn | University of Oxford | 2010-10-01 | 2018-08-31 | |
| Activity of Mefloquine Against Urinary Schistosomiasis Mefloquine, S/P - Urinary Schistosomiasis | Phase 2 | Completed | Albert Schweitzer Hospital | 65 | 2010-05-01 | 2013-01-24 |
| Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine cotrimoxazole, mefloquine - Malaria in Pregnancy, HIV Infections | Phase 3 | Completed | Institut de Recherche pour le Developpement | 430 | 2009-12-01 | 2013-01-23 |
| Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy Sulphadoxine-pyrimethamine, Mefloquine (full dose), Mefloquine (split dose) - Pregnancy, Malaria | Not applicable | Completed | Hospital Clinic of Barcelona | 5820 | 2009-09-01 | 2014-03-20 |
| Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine AD 452 (+) mefloquine, Racemic Mefloquine, Placebo - Healthy Subjects | Phase 1 | Completed | Treague Ltd | 46 | 2009-06-01 | 2010-08-03 |
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Malaria (21) · Malaria, Falciparum (11) · HIV Infections (4) · Schistosomiasis haematobia (2) · Acquired Immunodeficiency Syndrome (1) · Alzheimer Disease (1) · Anemia, Sickle Cell (1) · COVID-19 (1) · Central Nervous System Diseases (1) · Cognitive Dysfunction (1) · Disease (1) · Glioblastoma (1) · Gliosarcoma (1) · HIV Seropositivity (1) · Infections (1)
Armed Forces Research Institute of Medical Sciences, Thailand (3) · Institute of Tropical Medicine, Belgium (3) · London School of Hygiene and Tropical Medicine (3) · U.S. Army Medical Research and Development Command (3) · University of Oxford (3) · Centers for Disease Control and Prevention (2) · Pfizer (2) · Albert Schweitzer Hospital (1) · Biogen (1) · Burnasyan Federal Medical Biophysical Center (1) · Global Emerging Infections Surveillance and Response System (1) · Helwan University (1) · Hospital Clinic of Barcelona (1) · Institut de Recherche pour le Developpement (1) · Instituto Nacional de Salud. Peru (1)
Cambodia (5) · Thailand (4) · Ghana (3) · Kenya (3) · Mali (3) · Tanzania (3) · United States (3) · Zambia (3) · Benin (2) · Burkina Faso (2) · Gabon (2) · Nigeria (2) · Peru (2) · Senegal (2) · Brazil (1)
Duong Socheat, MD (2) · Umberto D'Alessandro, MD,MSc, PHD (2) · Alexandre Macedo de Oliveira, MD, MSc (1) · Ben Andagalu, MD (1) · Braden Hale, MD (1) · Brian Greenwood, FRCP, FRS (1) · Chanthap Lon, MD (1) · Clara Menendez, MD, PhD (1) · Daniel Chandramohan, MBBS,PhD (1) · Felix Tietche, Prof (1) · Frank Smithuis, MD (1) · Isabelle Borghini-Fuhrer, PhD (1)
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