13 completed, 3 recruiting, 3 terminated, 3 unknown. 24 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 24 | Completed 13, Recruiting 3, Terminated 3, Unknown 3, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 6 | Completed 4, Terminated 1, Unknown 1 |
Follow Respiratory Failure: new trials by email Literature Review of Respiratory Failure trials Research Report on Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients Phosphocreatine, Placebo - Hypotension, Consciousness, Level Altered | Phase 3 | Recruiting | Università Vita-Salute San Raffaele | 400 | 2024-10-08 | 2025-08-06 |
| Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation Noradrenaline - Critical Illness, Respiratory Failure | Phase 3 | Recruiting | University of Turin, Italy | 420 | 2024-08-01 | 2025-03-28 |
| Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome Precision ventilation, Guided usual care ventilation - Acute Respiratory Distress Syndrome, Respiratory Failure | Phase 3 | Recruiting | Beth Israel Deaconess Medical Center | 1100 | 2024-06-24 | 2026-06-29 |
| Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients Cuff Leak Test, Dexamethasone 4mg - Respiratory Failure | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 100 | 2023-04-05 | 2025-03-10 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial) Salbutamol, 0,9% Chloride Sodium - TTN, Respiratory Failure | Phase 3 | Active not recruiting | Medical University of Warsaw | 608 | 2021-12-31 | 2025-11-18 |
| Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial Angiotensin 1-7, Placebos - Coronavirus, Respiratory Failure | Phase 2 / Phase 3 | Unknown | Erasme University Hospital | 60 | 2021-12-30 | 2021-08-02 |
| Comparative Evaluation of the McGrath Videolaryngoscope and the Direct Laryngoscopy for Tracheal Intubation in the Prehospital Setting Videolaryngoscopy group, Direct laryngoscopy group - Indication of Orotracheal Intubation, Cardio Respiratory Arrest | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 150 | 2021-06-15 | 2021-06-18 |
| Furosemide as Supportive Therapy for COVID-19 Respiratory Failure Nebulized Furosemide, Nebulized Saline - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Terminated | Dr. John Muscedere | 40 | 2021-04-16 | 2023-12-11 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Reduced Anticoagulation Targets in ECLS (RATE) Heparin, LMWH - Heart Failure, Respiratory Failure | Phase 3 | Completed | University Medical Center Groningen | 330 | 2020-10-01 | 2025-05-02 |
| Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial Azithromycin, Hydroxychloroquine, Placebo - COVID-19, Respiratory Failure | Phase 3 | Terminated | Frantisek Duska, MD, PhD | 3 | 2020-05-13 | 2020-11-06 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Self-management of Sedative Therapy by Ventilated Patients Dexmedetomidine - Critical Illness, Anxiety | Phase 2 / Phase 3 | Completed | Mayo Clinic | 161 | 2016-11-01 | 2025-10-02 |
| Astral VAPS AutoEPAP Clinical Trial Astral - Upper Airway Obstruction, Respiratory Insufficiency | Phase 3 | Completed | ResMed | 42 | 2016-04-15 | 2019-07-26 |
| Modafinil Versus Placebo for Hypoactive Delirium in the Critically Ill Modafinil, Placebo - Delirium, Respiratory Failure | Phase 3 | Withdrawn | Brigham and Women's Hospital | 2014-01-01 | 2016-11-03 | |
| Heart And Lung Failure - Pediatric INsulin Titration Trial Insulin - Heart Failure, Respiratory Failure | Phase 3 | Completed | Boston Children's Hospital | 713 | 2012-04-01 | 2022-07-25 |
| Intellivent Versus Conventional Ventilation Intellivent; automatic mode implemented on a S1 ventilator - Respiratory Failure, Self Efficacy | Phase 3 | Completed | Hamilton Medical AG | 80 | 2011-02-01 | 2012-12-06 |
| Donor Simvastatin Treatment in Organ Transplantation Simvastatin 80mg, Control Rx - Heart Failure, Respiratory Failure | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 84 | 2010-06-01 | 2017-09-19 |
| Dexmedetomidine Pharmacokinetics-pharmacodynamics in Mechanically Ventilated Children With Single-organ Respiratory Failure dexmedetomidine, Vital signs, blood sampling - Respiratory Failure | Phase 3 | Terminated | University Hospital, Ghent | 1 | 2009-12-01 | 2011-10-04 |
Showing 20 of 24. Sign in to see all of them.
Respiratory Insufficiency (24) · Critical Illness (4) · Heart Failure (4) · COVID-19 (3) · Heart Arrest (2) · Hypotension (2) · Respiratory Aspiration (2) · Airway Obstruction (1) · Anxiety Disorders (1) · Bradycardia (1) · Consciousness Disorders (1) · Coronavirus Infections (1) · Delirium (1) · Healthcare-Associated Pneumonia (1) · Hemorrhage (1)
Respiration Disorders (24) · Respiratory Tract Diseases (24) · Pathological Conditions, Signs and Symptoms (12) · Pathologic Processes (11) · Cardiovascular Diseases (6) · Infections (6) · Lung Diseases (6) · Disease Attributes (5) · Heart Diseases (5) · Pneumonia (5) · Respiratory Tract Infections (5) · Virus Diseases (5) · Coronaviridae Infections (4) · Nidovirales Infections (4) · RNA Virus Infections (4)
Azithromycin (2) · Dexmedetomidine (2) · Hydroxychloroquine (2) · Norepinephrine (2) · Albuterol (1) · Blood Specimen Collection (1) · Dexamethasone (1) · Enoxaparin (1) · Heparin (1) · Heparin, Low-Molecular-Weight (1) · Insulin (1) · Mefloquine (1) · Midazolam (1) · Modafinil (1) · Nadroparin (1)
Assistance Publique - Hôpitaux de Paris (2) · Australian National University (1) · Beth Israel Deaconess Medical Center (1) · Boston Children's Hospital (1) · Brigham and Women's Hospital (1) · Burnasyan Federal Medical Biophysical Center (1) · C. R. Bard (1) · Dr. John Muscedere (1) · Erasme University Hospital (1) · Frantisek Duska, MD, PhD (1) · Hamilton Medical AG (1) · Helsinki University Central Hospital (1) · Mayo Clinic (1) · Medical University of Warsaw (1) · ResMed (1)
United States (9) · Canada (3) · Belgium (2) · France (2) · Italy (2) · Australia (1) · Brazil (1) · Czechia (1) · Finland (1) · Ireland (1) · Kuwait (1) · Netherlands (1) · Poland (1) · Russia (1) · Switzerland (1)
Daniel Talmor, MD MPH (1) · Dr. Kimberley Lewis, MD (1) · Filippo Annoni, MD (1) · Frank MP van Haren, MD, PhD (1) · Gerald L Weinhouse, MD (1) · John G Laffey, MD (1) · John Muscedere, MD (1) · Jose R Fioretto, MD, PhD (1) · Karl B Lemstrom, MD, PhD (1) · Linda L Chlan, RN, PhD (1) · Lisa Wolfe, MD (1) · Marin H Kollef, MD (1) · Matthew Koroscil, MD (1) · Michael SD Agus, MD (1)
PMID 18714060, PMID 18989547, PMID 20302428, PMID 21403073, PMID 28118549, PMID 31012225, PMID 31120585, PMID 31352795, PMID 31529354, PMID 31577692, PMID 31585796, PMID 31910992, PMID 32641163, PMID 32740181, PMID 33755076, PMID 33932465, PMID 35578271, PMID 36656551, PMID 36714639, PMID 37526194, PMID 37693502, PMID 38066613, PMID 39907523, PMID 40087802, PMID 40537229, PMID 41527181, PMID 42413523
1UG3HL166785 (1), 2019 (1), R01HL130881 (1), U01HL107681 (1), U24HL166784 (1)