20 completed, 10 recruiting, 9 terminated, 6 withdrawn. 22 Not applicable, 7 Phase 1, 6 Phase 2, 5 Phase 4, 4 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Studies Testing the Use of Oral Amitriptyline in Reducing Localized Burn Injury-induced Microvesicle Particle Release Amitriptyline, Placebo - Microvesicle Particles, Thermal Burn | Phase 1 | Not yet recruiting | Wright State University | 20 | 2027-06-01 | 2026-07-17 |
| Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline Amitriptyline, Placebo - Thermal Burn, Amitriptyline | Phase 1 | Not yet recruiting | Wright State University | 50 | 2026-10-01 | 2026-09-30 |
| Mechanisms for Laser-Induced Rejuvenation Fractionated Laser Resurfacing - Skin Cancer | Not applicable | Recruiting | Wright State University | 12 | 2025-07-16 | 2026-05-22 |
| AI-Augmented Motivational Interviewing Training for Primary Care Basic AI (artificial intelligence)-Augmented Motivational Interviewing Training, Plus AI (artificial intelligence)-Augmented Motivational Interviewing Training - Multiple Chronic Conditions, Patient Engagement | Not applicable | Not yet recruiting | Wright State University | 150 | 2025-07-01 | 2024-09-19 |
| Sphenopalatine Ganglion Block and Cold Induced Headaches Lidocaine Topical 4% Topical Solution, Bitrex, normal saline - Cold Induced Headache, Brain Freeze | Phase 1 | Active not recruiting | Wright State University | 30 | 2025-01-01 | 2025-01-31 |
| Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage Lidocaine (drug), Tx 360 - Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache | Phase 4 | Recruiting | Wright State University | 20 | 2024-05-20 | 2026-05-27 |
| The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population Fractionated Laser Resurfacing - Actinic Keratoses, Aging | Not applicable | Recruiting | Wright State University | 80 | 2024-03-20 | 2026-07-16 |
| Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea Imipramine, Amitriptyline, Vehicle - Rosacea | Phase 2 | Recruiting | Wright State University | 48 | 2024-02-27 | 2026-02-18 |
| Improving Relationships Using Motivational Interviewing Motivational interviewing training enhanced with artificial intelligence - Physician-Patient Relations, Diabetes Mellitus, Type 2 | Not applicable | Withdrawn | Wright State University | 2024-02-01 | 2024-03-05 | |
| Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin - Microbial Colonization, Gut Microbiota | Not applicable | Unknown | National Research Centre, Egypt | 72 | 2023-06-01 | 2024-08-20 |
| The Validation of New Photographic Technology for Assessing Skin Lesions Skin Lesions | Completed | Wright State University | 200 | 2023-02-15 | 2025-02-06 | |
| The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy Imipramine, Vehicle - Imipramine, Photodynamic Therapy | Phase 1 | Recruiting | Wright State University | 24 | 2023-01-19 | 2026-08-20 |
| DNA Repair Activity in the Skin of Day and Night Shift Workers Ultraviolet B Radiation, No Ultraviolet B Radiation - Skin Cancer | Not applicable | Recruiting | Wright State University | 48 | 2022-12-07 | 2026-07-17 |
| Teen Driving Translation Study (NIH) In-vehicle Device, Expert-Delivered Parent Communication Training, Peer-Delivered Parent Communication Training - Drive, Recidivism | Phase 3 | Active not recruiting | Ginger Yang | 588 | 2022-11-17 | 2026-07-21 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| Defining N-Acetyl Cysteine as a Treatment for Inhibiting Prurogenic Stimuli N-acetyl cysteine, Placebo - Pruritus, Skin Disorder | Early Phase 1 | Completed | Wright State University | 20 | 2022-06-19 | 2024-03-06 |
| Testing Use of Topical Imipramine in Reducing Ultraviolet B Induced Microvesicle Particle Release in Photosensitive Subjects 4% Imipramine Cream, Base Cream - Photosensitivity, Microvesicle Particle | Phase 1 | Recruiting | Wright State University | 40 | 2022-06-06 | 2025-01-27 |
| "Up-Armoring" At-Risk Military Couples: A Stepped Approach to Early Intervention and Strengthening of Military Families ARMOR Online - Couples Therapy, Military Family | Not applicable | Completed | Wright State University | 581 | 2021-10-19 | 2025-04-29 |
| Photodynamic Therapy and Microvesicles Photodynamic Therapy, 4% Imipramine, Base Cream - Photodynamic Therapy, Microvesicle Particle | Early Phase 1 | Withdrawn | Wright State University | 2021-03-29 | 2022-09-13 | |
| Pilot Studies Testing Levels of P63 in Psoriasis Skin Lesions No intervention - Psoriasis Subject, No intervention - Control Subject - Psoriasis | Completed | Wright State University | 9 | 2020-12-03 | 2023-04-21 |
Showing 20 of 52. Sign in to see all of them.
Keratosis, Actinic (4) · Substance-Related Disorders (3) · Headache (2) · Kidney Failure, Chronic (2) · Pre-Eclampsia (2) · Skin Neoplasms (2) · Acute Lung Injury (1) · Agnosia (1) · Anemia (1) · Aneurysm (1) · Bias, Implicit (1) · Burnett Schwartz Berberian syndrome (1) · Burnout, Professional (1) · COVID-19 (1) · Carcinoma, Hepatocellular (1)
Amitriptyline (3) · Imipramine (3) · Saline Solution (3) · Adalimumab (2) · Ascorbic Acid (2) · Lidocaine (2) · Acetylcysteine (1) · Alendronate (1) · Alkalies (1) · Artificial Intelligence (1) · Celecoxib (1) · Chlorhexidine (1) · Cholecalciferol (1) · Cinacalcet (1) · Etanercept (1)
United States (49) · Poland (2) · Egypt (1) · Italy (1)
Jeffrey B Travers, MD, PhD (9) · Craig Rohan, MD (2) · David F Fiorentino, MD, PhD (2) · Jeffrey Travers, MD, PhD (2) · Paul J Hershberger, PhD (2) · Sheela Barhan, MD (2) · Steven Lindheim, MD (2) · Alan L Peterson, PhD, ABPP (1) · Amanda Roman, MD (1) · Amr Elbahnasawy, PhD (1) · Brenda M Booth, Ph.D. (1) · Brian P Murray, DO (1) · Dean A Bricker, MD (1) · Geoffrey Towers, MD (1) · Gregory Brigham, Ph.D. (1)
PMID 20562130, PMID 20802164, PMID 22906363, PMID 26696251, PMID 29283612, PMID 31735660, PMID 31736123, PMID 32511207, PMID 32592693, PMID 32883337, PMID 33078388, PMID 34231877, PMID 34428179, PMID 35604745, PMID 35676708, PMID 38303661, PMID 40658616
1RC1DA028467-01 (1), R01DA015690 (1), R01DK080770 (1)