294 completed, 184 unknown, 81 recruiting, 49 not yet recruiting. 226 Not applicable, 117 Phase 2, 68 Phase 1, 61 Phase 4, 50 Phase 3.
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment - Acute-On-Chronic Liver Failure | Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2028-01-01 | 2025-08-17 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial ucMSC and Standard medical treatment, Standard medical treatment - Acute-On-Chronic Liver Failure | Phase 2 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2027-01-01 | 2025-08-20 |
| Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE) Microbiota transplant therapy (MTT) capsules, Placebo capsule - Hepatic Encephalopathy, Cirrhosis | Phase 2 | Not yet recruiting | VA Office of Research and Development | 162 | 2026-10-30 | 2026-04-14 |
| A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. Standard of Care (Investigator Choice), DIALIVE 2.0 liver dialysis Device plus available Standard of Care - Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis | Not applicable | Recruiting | Yaqrit Ltd | 72 | 2026-10-01 | 2026-09-22 |
| Pre-emptive RTO for An Early Detected Gastric Varices in CT/MR Angiogram Trial Non-selective beta blockers, Retrograde transvenous obliteration - Gastric Varices | Not applicable | Not yet recruiting | University of California, Los Angeles | 68 | 2026-10-01 | 2026-07-02 |
| Prevalence and Prognosis of Drug-Induced Liver Injury Drug-Induced Liver Injury | Not yet recruiting | Assiut University | 80 | 2026-10-01 | 2026-09-21 | |
| Electronic PHES vs Paper-based PHES for Hepatic Encephalopathy Paper-based Psychometric Hepatic Encephalopathy Score (PHES), Electronic Psychometric Hepatic Encephalopathy Score (PHES) - Liver Cirrhosis, Hepatic Encephalopathy | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 80 | 2026-10-01 | 2026-10-01 |
| A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy wechat mini-program - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 700 | 2026-10-01 | 2026-10-01 | |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| Equivalence of Electronic vs Paper-based PHES in Diagnosing Hepatic Encephalopathy Paper-based PHES, Electronic PHES - Liver Cirrhosis, Hepatic Encephalopathy (HE) | Not applicable | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 80 | 2026-10-01 | 2026-10-14 |
| Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure NTZ 500mg BID on top of SOC - Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure | Phase 2 | Not yet recruiting | Genfit | 16 | 2026-10-01 | 2026-07-09 |
| Very Low-volume Plasma Exchange in ACLF Double Plasma Molecular Adsorption System (DPMAS), Low-volume plasma exchange, Prothrombin Complex Concentrate (PCC) - Acute on Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 840 | 2026-10-01 | 2026-10-05 |
| Effect of Mini-Program Monitoring on Hepatic Encephalopathy in Post-TIPS Patients Standard Care and Routine Follow-Up, Hepatic Encephalopathy Intelligent Monitoring Mini-Program - Hepatic Encephalopathy, Liver Cirrhosis | Not applicable | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 394 | 2026-10-01 | 2026-10-28 |
| Risk Factors and Outcomes of Hepatitis A in Children Hepatitis A, Acute Hepatitis | Not yet recruiting | Assiut University | 190 | 2026-09-26 | 2026-09-30 | |
| VitaSmart HOPE System: Bridge to HOPE Registry hypothermic oxygenated perfusion therapy of a donor liver under standard of care conditions - End Stage Liver DIsease, Liver Failure | Enrolling by invitation | Bridge to Life Ltd. | 5000 | 2026-09-01 | 2026-05-22 | |
| Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis Daridorexant, Placebo - Liver Cirrhosis, Sleep Disturbance | Phase 4 | Not yet recruiting | Wang Fengmei | 180 | 2026-09-01 | 2026-10-16 |
| Coil-Assisted Small-Diameter Covered-Stent Shunt Reduction for Refractory Hepatic Encephalopathy After TIPS Coil-assisted Small-diameter Stent Shunt reduction - Hepatic Encephalopathy, Transjugular Intrahepatic Portosystemic Shunt (TIPS) | Not applicable | Recruiting | Air Force Military Medical University, China | 30 | 2026-09-01 | 2026-09-02 |
| TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation - Liver Failure | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-09-01 | 2026-10-07 |
| 4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis 4D-Flow Liver and heart MRI with Gadolinium injection, Samples Without DNA - Cirrhosis, Portal Hypertension | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-08-25 | 2026-10-13 |
| CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure Preoperative CT volumetry with hepatic vascular deformation mapping (VDM) - Post-Hepatectomy Liver Failure, Liver Failure | Recruiting | Minia University | 1070 | 2026-08-15 | 2026-08-18 |
Showing 20 of 723. Sign in to see all of them.
Hepatic Encephalopathy (218) · Acute-On-Chronic Liver Failure (163) · End Stage Liver Disease (151) · Liver Cirrhosis (116) · Fibrosis (115) · Liver Failure, Acute (96) · Liver Diseases (62) · Hypertension, Portal (28) · Hepatitis B (24) · Renal Insufficiency (21) · Acute Kidney Injury (17) · Ascites (17) · Carcinoma, Hepatocellular (16) · Liver Neoplasms (16)
Digestive System Diseases (721) · Hepatic Insufficiency (710) · Liver Diseases (661) · Pathological Conditions, Signs and Symptoms (292) · Pathologic Processes (279) · Nervous System Diseases (252) · Nutritional and Metabolic Diseases (243) · Central Nervous System Diseases (236) · Metabolic Diseases (231) · Brain Diseases (225) · Brain Diseases, Metabolic (221) · Liver Failure, Acute (150) · Fibrosis (95) · Infections (60)
Lactulose (38) · Rifaximin (29) · Albumins (15) · Fecal Microbiota Transplantation (14) · Plasma Exchange (12) · ornithylaspartate (12) · Standard of Care (11) · Acetylcysteine (9) · Blood Specimen Collection (8) · Liver Transplantation (8) · Granulocyte Colony-Stimulating Factor (7) · Sodium Chloride (6) · Terlipressin (6) · Amino Acids, Branched-Chain (5) · Continuous Renal Replacement Therapy (5)
Institute of Liver and Biliary Sciences, India (52) · Post Graduate Institute of Medical Education and Research, Chandigarh (19) · Third Affiliated Hospital, Sun Yat-Sen University (19) · Assistance Publique - Hôpitaux de Paris (12) · Nanfang Hospital, Southern Medical University (11) · Air Force Military Medical University, China (9) · Sun Yat-sen University (9) · Hunter Holmes Mcguire Veteran Affairs Medical Center (8) · Assiut University (7) · Mayo Clinic (7) · RenJi Hospital (7) · Bausch Health Americas, Inc. (6) · Copenhagen University Hospital, Rigshospitalet (6) · Govind Ballabh Pant Hospital (6) · University of Aarhus (6)
United States (188) · China (113) · India (90) · France (41) · United Kingdom (39) · Italy (35) · Spain (35) · Germany (33) · Canada (30) · Belgium (29) · Egypt (20) · Denmark (19) · Austria (15) · South Korea (14) · Turkey (Türkiye) (13)
Liang Peng, Doctor (7) · Barjesh C Sharma, MD,DM (3) · Daiming Fan (3) · Dr. Shiv Kumar Sarin, DM (3) · Elliot Tapper, MD (3) · Hai Li (3) · James Trotter, MD (3) · Lindsey Mathew (3) · Patricia Bloom, MD (3) · Qin Ning, MD., PhD. (3) · William M Lee, MD (3) · Aldo Torre Delgadillo, M.D. M.Sc (2) · Andres Duarte-Rojo, MD (2)
PMID 37467180, PMID 37183883, PMID 31172417, PMID 16950959, PMID 19524577, PMID 20335583, PMID 23474284, PMID 23872605, PMID 27720916, PMID 28209134, PMID 28506905, PMID 28928275, PMID 29960156, PMID 31038755, PMID 32109631, PMID 34412498, PMID 34907041, PMID 35037228, PMID 35313729, PMID 36052222, PMID 37517452, PMID 38349709, PMID 42649506, PMID 10051463, PMID 10189326, PMID 10218526, PMID 10371175, PMID 10545534, PMID 10546860, PMID 10563713, PMID 10634199, PMID 10670636, PMID 10749332, PMID 10789605, PMID 10898704, PMID 10971863, PMID 10988097, PMID 11071184, PMID 11188837, PMID 11216928, PMID 11262215, PMID 11283862, PMID 11303131, PMID 11366976, PMID 11399982, PMID 11544428, PMID 11719381, PMID 11722270, PMID 11737323, PMID 11740189
U01DK058369 (4), 2009 (2), 2017 (2), 2018 (2), 2019 (2), 2025 (2), U01DK062436 (2), U01DK072146 (2), 2008 (1), 2014 (1), 2016 (1), 2023 (1), N01CM00100 (1), P30AG024824 (1), P30CA047904 (1)