24 completed, 10 unknown, 4 terminated, 4 withdrawn. 14 Not applicable, 11 Phase 2, 8 Phase 3, 8 Phase 4, 7 Phase 1.
Follow Plasmalyte A: new trials by email Literature Review of Plasmalyte A trials Research Report on Plasmalyte A
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypertonic Saline in Posterior Spinal Fusion Normosol-R, buffered 2% hypertonic saline - Scoliosis Idiopathic, Scoliosis;Congenital | Phase 2 / Phase 3 | Withdrawn | Joseph D. Tobias | 2025-12-01 | 2025-11-10 | |
| CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid - Critical Care, Intensive Care, Fluid Accumulation | Phase 4 | Recruiting | University Hospital, Antwerp | 640 | 2025-10-07 | 2026-02-03 |
| To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery Pentoxifylline (also known as oxpentifylline), Plasmalyte - Liver Regeneration | Not applicable | Recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-01-01 | 2025-07-25 |
| Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Challenge Compared to DENV and ZIKV-naïve Controls Against Infection With ZIKV-SJRP Challenge TetraVax-DV-TV003 (TV003), Plasmalyte, Challenge virus ZIKV-SJRP/2016-184 - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 27 | 2024-09-24 | 2026-03-09 |
| Cartilage Recovery in Adults With Knee Osteorthritis by Mesenchymal Cell Therapy: Randomized Trial of Radiologic and Clinical Outcomes INMUNOCEM, PLACEBO COMPARATOR - Knee Osteoarthritis | Phase 2 | Unknown | GUSTAVO SALGUERO | 32 | 2023-10-01 | 2023-07-07 |
| Efficacy of 5% Albumin v/s Plasmalyte in Combination With 20% Albumin for Fluid Resuscitation in Cirrhosis With Sepsis Induced Hypotension 20% Albumin, 5% Albumin, Plasmalyte - Liver Cirrhosis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 120 | 2023-09-30 | 2023-10-10 |
| Crystalloid Fluids and Cardiac Surgery Normal Saline for fluid resuscitation, PlasmaLyte for fluid resuscitation, Ringer's Lacatate for fluid resusciation - Surgery-Complications | Not applicable | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2023-03-31 | 2025-02-21 | |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects L-citrulline, Plasmalyte A - Ventricular Septal Defect, Atrioventricular Septal Defect | Phase 3 | Terminated | Asklepion Pharmaceuticals, LLC | 64 | 2022-06-29 | 2024-09-19 |
| Inflammatory Consequences of Crystalloids in Severely Burned Patients PlasmaLyte for fluid resuscitation, Ringer's Lactate for fluid resuscitation - Burns | Not applicable | Terminated | Centre hospitalier de l'Université de Montréal (CHUM) | 14 | 2021-10-17 | 2025-02-21 |
| Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke Adjusted medication - Acute Ischemic Stroke | Phase 4 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 814 | 2021-06-01 | 2023-03-16 |
| Balanced Crystalloid Solutions for Acute Pancreatitis Balanced crystalloid solution, Normal saline - Acute Pancreatitis | Phase 4 | Unknown | University Hospital Rijeka | 276 | 2020-05-01 | 2020-12-30 |
| The Effect of Vitamin D Supplementation on COVID-19 Recovery Vit-D 0.2 MG/ML Oral Solution [Calcidol], Physiological Irrigating Solution - Covid19 | Phase 3 | Completed | University of Monastir | 130 | 2020-04-22 | 2021-05-12 |
| Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells Mesenchymal Stem Cells (MSCs), Placebo Infusion (Plasmalyte A with 0.5% human serum albumin) - Diabetes Mellitus, Type 1 | Phase 1 | Active not recruiting | Medical University of South Carolina | 60 | 2020-02-27 | 2026-04-22 |
| Comparison of Lactated Ringer's Solution and PlasmaLyte-A as a Base Solution for Del Nido Cardioplegia Lactated Ringer - Myocardial Injury | Not applicable | Completed | Mahidol University | 200 | 2019-08-05 | 2024-03-15 |
| Balanced Solutions and Plasma Electrolytes Lactated Ringer's, Normosol - Critical Illness, Acidosis, Metabolic | Not applicable | Completed | Vanderbilt University Medical Center | 2093 | 2018-06-01 | 2019-10-11 |
| Better Evidence for Selecting Transplant Fluids Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP - End Stage Kidney Disease, Delayed Graft Function | Phase 3 | Completed | The University of Queensland | 808 | 2018-01-26 | 2024-10-15 |
| Influence of Albumin on Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation Human albumin, Plasmalyte - Acute Kidney Injury | Phase 4 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 250 | 2018-01-10 | 2018-01-25 |
| Fluid Resuscitation in Burn Patients Plasmalyte, Ringer lactate - Severe Burns, Fluid Resuscitation | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 28 | 2017-08-09 | 2019-12-13 |
| A Low ChloridE hyperTonic Solution for Brain Edema Sodium chloride /sodium acetate (16.4%), Sodium chloride (23.4%), PlasmaLyte - Subarachnoid Hemorrhage, Acute Kidney Injury | Phase 1 | Completed | Emory University | 59 | 2017-06-28 | 2023-05-01 |
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Acute Kidney Injury (5) · Acidosis (4) · Critical Illness (4) · Burns (2) · Hyponatremia (2) · Hypotension (2) · Myocardial Infarction (2) · Osteoarthritis (2) · Osteoarthritis, Knee (2) · Shock (2) · Acid-Base Imbalance (1) · Aneurysm (1) · Anterior Wall Myocardial Infarction (1) · Aortic Aneurysm (1) · Aortic Aneurysm, Abdominal (1)
Stempeutics Research Pvt Ltd (5) · Institute of Liver and Biliary Sciences, India (3) · Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Centre hospitalier de l'Université de Montréal (CHUM) (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Asklepion Pharmaceuticals, LLC (1) · Assistance Publique - Hôpitaux de Paris (1) · Austin Health (1) · Brugmann University Hospital (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Emory University (1) · GUSTAVO SALGUERO (1) · Johns Hopkins University (1) · Joseph D. Tobias (1) · Mahidol University (1)
United States (14) · India (8) · Canada (6) · Belgium (3) · Australia (2) · Malaysia (2) · Spain (2) · Croatia (1) · France (1) · New Zealand (1) · South Korea (1) · Thailand (1) · Tunisia (1)
Alexandre Joosten, MD (1) · Anna Durbin, M.D. (1) · Bhibas Dasgupta, MS (1) · Brigitte Ickx, Md, Pr (1) · Christopher Mastropietro, MD, FCCM (1) · Dato' Dr. Ramli Baba, MS (1) · Dr Abdul Syukur Abdullah, MD (1) · Dr Abhinav Verma, MD (1) · Dr Chuah Siew Kee, MD (1) · Dr Dato K Chandran, MD (1) · Dr Irene Looi, MD (1) · Dr Uduman Ali Mohamed Yousuf, MD (1) · Dr Yau Weng Keong, MD (1)
PMID 10102718, PMID 11046201, PMID 12243433, PMID 15115561, PMID 15591303, PMID 16537374, PMID 18666740, PMID 19115651, PMID 21037437, PMID 21705897, PMID 22816029, PMID 23073953, PMID 23325915, PMID 23732264, PMID 23758736, PMID 24253140, PMID 24415398, PMID 24891325, PMID 25472864, PMID 25484310, PMID 25593740, PMID 26123384, PMID 27749094, PMID 27993154, PMID 30428930, PMID 30455077, PMID 32391156, PMID 32450917, PMID 33974564, PMID 34315432, PMID 35042554, PMID 35460725, PMID 36803273, PMID 37343576, PMID 38244592, PMID 39208776, PMID 39971001, PMID 401925, PMID 42003602, PMID 42258192, PMID 8161863
2008 (1), 2025 (1), 5UM1HL087318 (1), R01DK118529 (1), U01HL108713 (1)