Healthcare-Associated Pneumonia: Clinical Trials

272 completed, 78 unknown, 51 recruiting, 36 terminated. 171 Not applicable, 64 Phase 3, 48 Phase 2, 42 Phase 4, 16 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	171	Completed 106, Recruiting 21, Unknown 17, Not yet recruiting 13, Terminated 5, Active not recruiting 4, Enrolling by invitation 3, Suspended 1, Withdrawn 1
Phase 3	64	Completed 31, Terminated 11, Unknown 11, Withdrawn 5, Recruiting 4, Not yet recruiting 2
Phase 2	48	Completed 23, Unknown 11, Terminated 9, Not yet recruiting 2, Withdrawn 2, Recruiting 1
Phase 4	42	Completed 27, Unknown 6, Recruiting 3, Terminated 3, Not yet recruiting 2, Withdrawn 1
Phase 1	16	Completed 10, Terminated 4, Unknown 2
Early Phase 1	7	Completed 5, Not yet recruiting 1, Unknown 1

Follow Healthcare-Associated Pneumonia: new trials by email Literature Review of Healthcare-Associated Pneumonia trials Research Report on Healthcare-Associated Pneumonia

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia	Phase 2 / Phase 3	Not yet recruiting	University Hospital Fattouma Bourguiba	400	2027-01-01	2026-10-08
Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS mNGS diagnose of VAP - VAP - Ventilator Associated Pneumonia		Not yet recruiting	Children's Hospital of Fudan University	400	2027-01-01	2026-10-27
Traditional Chinese Medicine in Multidrug-Resistant Bacterial Pneumonia Multi Drug Resistant Infections, Pneumnia		Not yet recruiting	Henan University of Traditional Chinese Medicine	652	2026-12-01	2026-10-30
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial Resistance-Optimised Precision Dosing, Standard Care Dosing - Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)	Not applicable	Not yet recruiting	The University of Queensland	610	2026-11-01	2026-09-15
Role of Inhaled Polymyxin as an Adjunct to Intravenous Therapy in Multidrug Resistant Ventilator-associated Pneumonia in Stroke Patients Inhaled colistin, Saline - Ventilator Associated Pneumonia ( VAP)	Early Phase 1	Not yet recruiting	Ain Shams University	78	2026-10-10	2026-10-08
Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia Tobramycin inhalation solution, 0.9% Sodium Chloride Placebo - Pneumonia, Ventilator-Associated	Phase 4	Not yet recruiting	Second Affiliated Hospital, Zhejiang University, School of Medicine	574	2026-10-07	2026-10-02
Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury Closed endotracheal suction system, Open endotracheal suction - Ventilator-associated Pneumonia, Traumatic Brain Injury	Not applicable	Not yet recruiting	Minia University	120	2026-10-04	2026-10-20
National Surveillance and Prevention of Neonatal VAP Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)		Not yet recruiting	University of Alberta	1500	2026-10-01	2026-06-25
BIS in ICU Interventional Study Device-guided sedation, standard sedation practice - Cardiac Surgical Procedures (Postoperative Population), Critical Illness	Not applicable	Not yet recruiting	Medical University of Graz	144	2026-10-01	2026-10-07
Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols Mobile-Based Microlearning Program, Routine Education - Ventilator-Associated Pneumonia	Not applicable	Not yet recruiting	Alexandria University	110	2026-10-01	2026-10-21
Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning airway clearance, subglottic secretion aspiration, Ceftriaxone 2 grams daily - Intubation Complication, Stroke, Ischemic	Phase 4	Not yet recruiting	Hospital San Carlos, Madrid	60	2026-09-15	2026-08-06
" Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pneumonia Acquired During Mechanical Ventilation in Patients Receiving Extracorporeal Membrane Veno-arterial Oxygenation " Amikacin, Standard of care - Pneumonia, Bacterial, Extracorporeal Membrane Oxygenation	Phase 2	Recruiting	Assistance Publique - Hôpitaux de Paris	26	2026-08-10	2026-08-13
Pneumonia After Cardiovascular Surgery With Artificial Intelligence Not applicable- observational study - Hospital Acquired Pneumonia		Recruiting	Tomsk National Research Medical Center of the Russian Academy of Sciences	700	2026-07-29	2026-08-11
Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients Serum Procalcitonin Measurement, Serum Zinc Measurement - Ventilator Acquired Pneumonia		Not yet recruiting	Sohag University	84	2026-07-07	2026-07-10
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit Probiotics, Standard management - Probiotic, Ventilator Associated Pneumonia	Not applicable	Recruiting	Tanta University	68	2026-07-01	2026-09-29
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study) PCR multiplex BioFire Pneumonia plus - VAP - Ventilator Associated Pneumonia, Antibiotic	Not applicable	Not yet recruiting	University Hospital, Geneva	170	2026-06-05	2026-04-29
Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated Tracheobronchitis Optimized and protocolized nebulization procedure. - Ventilator-Associated Pneumonia, Ventilator-Associated Tracheobronchitis	Phase 3	Not yet recruiting	University Hospital, Tours	250	2026-06-01	2026-06-24
Predictors and Outcomes of Ventilated Hospital-acquired Pneumonia mechanical ventilation (MV) - Hospital Acquired Pneumonia		Recruiting	Assiut University	151	2026-06-01	2026-06-25
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT) Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel) - Pneumonia - Bacterial	Not applicable	Recruiting	Hospital de Clinicas de Porto Alegre	150	2026-05-20	2026-09-17
Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial Microbiome-guided inhaled antibiotic prophylaxis, Placebo - Critical Illness, Mechanical Ventilation	Phase 2	Not yet recruiting	University of Calgary	70	2026-05-01	2026-03-11

Showing 20 of 484. Sign in to see all of them.

Narrower conditions

Pneumonia, Ventilator-Associated (417)  ·  Pneumonia (75)  ·  Cross Infection (30)  ·  Critical Illness (22)  ·  Sepsis (21)  ·  Pneumonia, Bacterial (20)  ·  Community-Acquired Pneumonia (19)  ·  Infections (17)  ·  COVID-19 (12)  ·  Urinary Tract Infections (12)  ·  Respiratory Tract Infections (11)  ·  Intraabdominal Infections (8)  ·  Pseudomonas Infections (7)  ·  Staphylococcal Infections (7)

Broader conditions

Disease Attributes (484)  ·  Pathologic Processes (484)  ·  Pathological Conditions, Signs and Symptoms (484)  ·  Iatrogenic Disease (483)  ·  Lung Diseases (482)  ·  Respiratory Tract Diseases (481)  ·  Respiratory Tract Infections (473)  ·  Infections (467)  ·  Cross Infection (454)  ·  Pneumonia (409)  ·  Bacterial Infections and Mycoses (51)  ·  Bacterial Infections (45)  ·  Systemic Inflammatory Response Syndrome (28)  ·  Inflammation (26)

Interventions

Vancomycin (13)  ·  Colistin (11)  ·  Doripenem (11)  ·  Chlorhexidine (10)  ·  Linezolid (8)  ·  Amikacin (7)  ·  Saline Solution (7)  ·  Standard of Care (7)  ·  Toothbrushing (7)  ·  Meropenem (6)  ·  Sodium Chloride (6)  ·  chlorhexidine gluconate (6)  ·  colistinmethanesulfonic acid (6)  ·  Cilastatin, Imipenem Drug Combination (5)  ·  Imipenem (5)

Sponsors

Pfizer (14)  ·  Assistance Publique - Hôpitaux de Paris (12)  ·  Assiut University (12)  ·  Nantes University Hospital (7)  ·  Ain Shams University (5)  ·  Fondation Hôpital Saint-Joseph (5)  ·  Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5)  ·  Tomsk National Research Medical Center of the Russian Academy of Sciences (5)  ·  University Hospital, Lille (5)  ·  Basilea Pharmaceutica (4)  ·  Cairo University (4)  ·  Region Skane (4)  ·  University of Thessaly (4)  ·  Alexandria University (3)  ·  Centre Hospitalier Departemental Vendee (3)

Countries

France (91)  ·  United States (74)  ·  China (32)  ·  Egypt (32)  ·  Spain (31)  ·  Brazil (22)  ·  Turkey (Türkiye) (21)  ·  Greece (20)  ·  Italy (20)  ·  Canada (19)  ·  Russia (18)  ·  United Kingdom (18)  ·  Thailand (15)  ·  Belgium (14)  ·  India (14)

Top investigators

Marin Kollef, MD (3)  ·  Sutep Jaruratanasirikul, MD (3)  ·  Daren Heyland, MD (2)  ·  Deborah J Cook, MD (2)  ·  Jean-Damien Ricard, MD, PhD (2)  ·  Lucy B Palmer, MD (2)

Results publications

PMID 17872488, PMID 19670912, PMID 20211892, PMID 20459721, PMID 24723282, PMID 26472037, PMID 26836896, PMID 30808293, PMID 33395094, PMID 33960817, PMID 34155899, PMID 34792787, PMID 35076335, PMID 38676438, PMID 41251370, PMID 10816031, PMID 11445675, PMID 11778260, PMID 11888973, PMID 11934711, PMID 12749509, PMID 1424930, PMID 14707570, PMID 15345979, PMID 15447947, PMID 15865552, PMID 15942342, PMID 17954801, PMID 17994522, PMID 18096127, PMID 18421435, PMID 18549664, PMID 18641114, PMID 18707849, PMID 18714060, PMID 18719064, PMID 18752007, PMID 18951395, PMID 18990201, PMID 18991508, PMID 19237884, PMID 19482956, PMID 19605577, PMID 19698010, PMID 19765321, PMID 20125046, PMID 20302428, PMID 20407057, PMID 20463812, PMID 20522788

NIH funding

2016 (3), 2018 (3), 2025 (2), R01NR007652 (2), 2009 (1), 2014 (1), 2015 (1), 2017 (1), 2019 (1), 2023 (1), 5UL1TR002240-05 (1), 5UM1AI104681 (1), K24AI141580 (1), R01DE014685 (1), R01GM115353 (1)