Respiratory Failure: Clinical Trials

306 completed, 104 unknown, 56 recruiting, 41 terminated. 274 Not applicable, 32 Phase 2, 24 Phase 3, 20 Phase 4, 13 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	274	Completed 143, Unknown 46, Recruiting 29, Terminated 26, Not yet recruiting 13, Withdrawn 9, Active not recruiting 6, Enrolling by invitation 1, Suspended 1
Phase 2	32	Completed 21, Unknown 6, Terminated 3, Recruiting 1, Withdrawn 1
Phase 3	24	Completed 13, Recruiting 3, Terminated 3, Unknown 3, Active not recruiting 1, Withdrawn 1
Phase 4	20	Completed 12, Unknown 3, Terminated 2, Active not recruiting 1, Recruiting 1, Withdrawn 1
Phase 1	13	Completed 8, Withdrawn 2, Not yet recruiting 1, Terminated 1, Unknown 1
Early Phase 1	1	Completed 1

Follow Respiratory Failure: new trials by email Literature Review of Respiratory Failure trials Research Report on Respiratory Failure

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes Nasal pressure assessment - Respiratory Failure		Not yet recruiting	University of Modena and Reggio Emilia	175	2027-05-01	2025-04-25
TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure	Not applicable	Not yet recruiting	CardioVision International Tech, S.A.S. de C.V.	360	2027-03-30	2026-10-13
Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation Oxygen therapy - Weaning From Mechanical Ventilation, Tracheostomy Weaning	Not applicable	Recruiting	Henrik Endeman	20	2026-12-31	2026-10-01
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS AutoEIT Model Training, AutoEIT Blinded Validation - ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure		Not yet recruiting	Ruijin Hospital	1200	2026-11-01	2026-10-27
Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm - Respiratory Failure, Extubation Failure	Not applicable	Not yet recruiting	University of Missouri-Columbia	50	2026-10-01	2026-07-28
Combined Lung and Diaphragmatic Ultrasound to Predict Respiratory Failure in Blunt Chest Trauma Blunt Chest Trauma, Respiratory Failure		Not yet recruiting	Assiut University	130	2026-10-01	2026-09-08
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease		Not yet recruiting	Assiut University	120	2026-10-01	2026-08-26
Mechanical Ventilator Adjustments and Patient Dyspnea Change to VC/AC, Change in Tidal Volume, Change in inspiratory flow - Respiratory Failure, Dyspnea During Mechanical Ventilation	Not applicable	Not yet recruiting	Beth Israel Deaconess Medical Center	20	2026-09-01	2026-07-14
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen - Trauma, Rib Fractures	Not applicable	Not yet recruiting	Loma Linda University	30	2026-09-01	2026-02-09
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure - Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)	Not applicable	Recruiting	Vastra Gotaland Region	25	2026-08-31	2026-09-02
Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury Epidural Electrode Implantation - Brain Injuries, Respiratory Failure	Not applicable	Not yet recruiting	Zhongda Hospital	10	2026-08-05	2026-08-14
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children Transcranial Doppler - Critical Illness, Pediatric Critical Illness		Recruiting	University of Wisconsin, Madison	125	2026-08-03	2026-08-27
Vela Generation II: Usability and Performance of a Non-Invasive Ventilation Mask. NIV interface with airway washout - Respiratory Insufficiency, Respiratory Failure	Not applicable	Not yet recruiting	Fisher and Paykel Healthcare	60	2026-07-01	2026-03-20
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI Epidural spinal cord stimulation - Spinal Cord Injury Cervical, Respiratory Failure	Not applicable	Recruiting	Zhongda Hospital	20	2026-06-01	2026-09-04
Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy Respiratory Failure, Heart Rate Variability (HRV)		Recruiting	University Health Network, Toronto	20	2026-05-26	2026-06-18
Mode of Ventilation During Critical Illness at Multiple Centers Volume control, Pressure control, Adaptive pressure control - Respiratory Failure, Mechanical Ventilation	Not applicable	Enrolling by invitation	Vanderbilt University Medical Center	4785	2026-05-01	2026-08-28
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients Morbid Obesity, Obesity		Not yet recruiting	Assiut University	45	2026-05-01	2026-04-21
Role of HFNC During FOB in Patients With Respiratory Failure High flow nasal canula - Respiratory Failure, Respiratory Failure With Hypercapnia	Not applicable	Recruiting	Mansoura University	60	2026-04-12	2026-10-19
Critical Care Admission Following Emergency Department's Resuscitation Room Care Emergency resuscitation room management (observational) - Critical Illness, Emergency Department Patient		Completed	Centre Hospitalier Universitaire de Nīmes	1629	2026-04-01	2026-06-24
Supraglottic Airway for Resuscitation in Preemies Supraglottic Airway - Respiratory Failure, Premature Neonates	Not applicable	Recruiting	University of Pennsylvania	20	2026-03-13	2026-07-14

Showing 20 of 563. Sign in to see all of them.

Narrower conditions

Respiratory Insufficiency (563)  ·  Critical Illness (51)  ·  COVID-19 (43)  ·  Respiratory Distress Syndrome (42)  ·  Pneumonia (26)  ·  Pulmonary Disease, Chronic Obstructive (26)  ·  Respiratory Aspiration (26)  ·  Heart Failure (24)  ·  Hypoxia (23)  ·  Sepsis (22)  ·  Shock (18)  ·  Acute Lung Injury (15)  ·  Coronavirus Infections (14)  ·  Heart Arrest (12)  ·  Respiration Disorders (12)

Broader conditions

Respiratory Tract Diseases (560)  ·  Respiration Disorders (551)  ·  Pathological Conditions, Signs and Symptoms (220)  ·  Pathologic Processes (162)  ·  Lung Diseases (150)  ·  Signs and Symptoms (102)  ·  Infections (101)  ·  Disease Attributes (88)  ·  Respiratory Tract Infections (74)  ·  Nervous System Diseases (62)  ·  Signs and Symptoms, Respiratory (53)  ·  Virus Diseases (52)  ·  Cardiovascular Diseases (51)  ·  RNA Virus Infections (51)  ·  Coronaviridae Infections (48)

Interventions

Noninvasive Ventilation (17)  ·  Standard of Care (9)  ·  Dexmedetomidine (8)  ·  Interactive Ventilatory Support (8)  ·  Saline Solution (6)  ·  Midazolam (5)  ·  Prone Position (5)  ·  Propofol (5)  ·  Blood Specimen Collection (4)  ·  Checklist (4)  ·  Fentanyl (4)  ·  Respiration, Artificial (4)  ·  Continuous Positive Airway Pressure (3)  ·  Restraint, Physical (3)  ·  Surveys and Questionnaires (3)

Sponsors

Massachusetts General Hospital (10)  ·  Beth Israel Deaconess Medical Center (8)  ·  Assiut University (7)  ·  Laval University (7)  ·  National Taiwan University Hospital (7)  ·  Wake Forest University Health Sciences (7)  ·  Centre d'Investigation Clinique et Technologique 805 (6)  ·  Hvidovre University Hospital (6)  ·  Southeast University, China (6)  ·  University Hospital, Bordeaux (6)  ·  Assistance Publique - Hôpitaux de Paris (5)  ·  Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5)  ·  St. Justine's Hospital (5)  ·  University Health Network, Toronto (5)  ·  University of Colorado, Denver (5)

Countries

United States (152)  ·  Italy (50)  ·  Canada (40)  ·  France (40)  ·  China (37)  ·  United Kingdom (23)  ·  Taiwan (20)  ·  Egypt (19)  ·  Turkey (Türkiye) (19)  ·  Spain (18)  ·  Brazil (16)  ·  Germany (16)  ·  Denmark (11)  ·  Switzerland (11)  ·  Netherlands (9)

Top investigators

Massimo Antonelli, MD (4)  ·  Steven Mink, MD (4)  ·  Davide Chiumello, MD (3)  ·  Jennifer Beck, PhD (3)  ·  Marcelo BP Amato, MD, PhD (3)  ·  Todd W Rice, MD, MSc (3)  ·  Alex Pearce, MD (2)  ·  Alexander Supady, Dr., MPH (2)  ·  Alexandre B Cavalcanti, MD (2)  ·  Alexandre Demoule, MD (2)  ·  Antonio Esquinas (2)  ·  Brian K Gehlbach, MD (2)  ·  D. Clark Files, MD (2)  ·  Daniel Talmor, MD MPH (2)

Results publications

PMID 27677861, PMID 34322364, PMID 36656551, PMID 38865147, PMID 10712328, PMID 10764299, PMID 10793162, PMID 10806150, PMID 11227314, PMID 11280630, PMID 11604980, PMID 11742961, PMID 11990923, PMID 12109234, PMID 12615617, PMID 12802491, PMID 14564379, PMID 14680089, PMID 15029473, PMID 15197438, PMID 15381517, PMID 15618461, PMID 15840076, PMID 15942342, PMID 16139155, PMID 16224108, PMID 16276167, PMID 16276177, PMID 16394778, PMID 16737982, PMID 17039354, PMID 17051488, PMID 17381569, PMID 17545931, PMID 17962636, PMID 18333732, PMID 18367735, PMID 18511703, PMID 18582931, PMID 18596631, PMID 18629471, PMID 18714060, PMID 18989547, PMID 19046447, PMID 19183949, PMID 19384209, PMID 19533092, PMID 19682735, PMID 19762075, PMID 19863829

NIH funding

K23HL088020 (2), 1UG3HL166785 (1), 2019 (1), 2023 (1), 2025 (1), K23AG066929 (1), K23HL145126 (1), K23HL155735 (1), K23HL175246 (1), R01HL114484 (1), R01HL130881 (1), R01NR007652 (1), R33HL162980 (1), R34HL125859 (1), R34HL150404 (1)