33 completed, 9 unknown, 6 terminated, 4 not yet recruiting. 22 Not applicable, 7 Phase 2, 6 Phase 1, 6 Phase 4, 4 Phase 3.
Follow Respiratory Depression: new trials by email Literature Review of Respiratory Depression trials Research Report on Respiratory Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| ENA-001 for Post Operative Respiratory Depression (PORD) ENA-001 - Respiratory Depression | Phase 2 | Not yet recruiting | Enalare Therapeutics Inc. | 200 | 2026-12-15 | 2026-02-27 |
| Oliceridine Versus Sufentanil Analgesia for Postoperative Patients With Obstructive Sleep Apnea Oliceridine, Sufentanil - Obstructive Sleep Apnea, Postoperative Analgesia | Not yet recruiting | Peking University First Hospital | 851 | 2026-09-01 | 2026-08-11 | |
| Dexmedetomidine vs Propofol in High-Risk ERCP Patients dexmedetomidin, Propofol - Respiratory Depression, Hypoxemia | Not applicable | Completed | Sisli Hamidiye Etfal Training and Research Hospital | 100 | 2025-09-03 | 2026-05-11 |
| ENA-001 for Opioid Induced Respiratory Depression ENA-001, Placebo Comparator - Respiratory Depression | Phase 1 | Completed | Enalare Therapeutics Inc. | 62 | 2025-05-14 | 2026-09-16 |
| Transcutaneous Electrical Stimulation for Apnea Detected by Capnography transcutaneous electrical nerve stimulation (TENS) - Respiratory Depression, Opioids | Not applicable | Completed | University of Toronto | 60 | 2025-04-10 | 2026-06-11 |
| Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments Remimazolam, Propofol - Postoperative Complications, Respiratory Depression | Phase 4 | Recruiting | Kaohsiung Veterans General Hospital. | 90 | 2025-02-12 | 2025-05-08 |
| Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression Propofol group, Remimazolam group - Respiratory Depression | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 96 | 2025-02-01 | 2025-02-10 |
| Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events Transcutaneous electrical acupoint stimulation, Conventional care plan - Extubation, Respiratory Depression | Not applicable | Recruiting | Nanjing First Hospital, Nanjing Medical University | 236 | 2025-01-25 | 2025-02-10 |
| Hemidiaphragmatic Paralysis Following Supraclavicular Brachial Plexus Blockade. Supraclavicular Brachial Plexus Blockade - Respiratory Depression | Unknown | Sohag University | 60 | 2024-07-01 | 2024-07-09 | |
| Precision Medicine in Anesthesia Fentanyl Drug Administration - Respiratory Depression | Withdrawn | University of Alabama at Birmingham | 2024-06-10 | 2025-02-05 | ||
| Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT) Closed-loop FiO2 controller, Conventional - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Recruiting | Başakşehir Çam & Sakura City Hospital | 50 | 2024-03-21 | 2025-01-28 |
| VitalThings Guardian Contactless Monitoring Vitalthings Guardian M10 fixed and M10 mobile - Respiratory Depression, Respiratory Failure | Completed | VitalThings | 41 | 2023-11-15 | 2023-12-05 | |
| Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure | Unknown | Yonsei University | 100 | 2023-11-01 | 2023-10-03 | |
| Oliceridine in Patients With Acute Burn Injuries Oliceridine, Historical opioid use - Acute Pain, Burns | Phase 4 | Completed | University of Tennessee | 31 | 2023-04-01 | 2023-10-26 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers Medicinal cannabis in combination with oxycodon, Medicinal cannabis in combination with placebo oxycodon - Respiratory Depression, Cannabis Use | Phase 4 | Unknown | Leiden University Medical Center | 20 | 2021-12-09 | 2022-02-11 |
| Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain VPIA pump, Morphine - Pain, Respiratory Depression | Phase 2 / Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 40 | 2021-03-31 | 2026-08-07 |
| Multimodal Perioperative Pain Management: ComfortSafe Program ComfortSafe Care - Post-operative Pain, Post-operative Nausea and Vomiting | Unknown | Georgetown University | 60 | 2020-05-11 | 2020-10-05 | |
| IPI-Guided Monitoring for Oxygen Desaturation in ERCP IPI GROUP, CONTROL GROUP - Respiratory Depression, Oxygen Desaturation | Not applicable | Completed | Merve Gökçe | 80 | 2019-10-18 | 2026-03-05 |
Showing 20 of 59. Sign in to see all of them.
Respiratory Insufficiency (59) · Pain, Postoperative (6) · Hypoxia (3) · Pain (3) · Sleep Apnea, Obstructive (3) · Acute Pain (2) · Chronic Pain (2) · Postoperative Complications (2) · Postoperative Nausea and Vomiting (2) · Vomiting (2) · Agnosia (1) · Asphyxia Neonatorum (1) · Bites and Stings (1) · Bradycardia (1) · Burns (1)
Respiration Disorders (59) · Respiratory Tract Diseases (59) · Pathological Conditions, Signs and Symptoms (24) · Signs and Symptoms (21) · Neurologic Manifestations (15) · Pathologic Processes (11) · Pain (9) · Nervous System Diseases (7) · Postoperative Complications (7) · Apnea (5) · Dyssomnias (5) · Signs and Symptoms, Respiratory (5) · Sleep Disorders, Intrinsic (5) · Sleep Wake Disorders (5) · Sleep Apnea Syndromes (4)
Fentanyl (4) · Dexmedetomidine (3) · Morphine (3) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (2) · Ozone (2) · Propofol (2) · Remifentanil (2) · Acetaminophen (1) · Anesthesia, Spinal (1) · Buprenorphine (1) · Capnography (1) · Carbon Dioxide (1) · Cesarean Section (1) · Dexamethasone (1) · Echocardiography, Doppler (1)
Medtronic - MITG (3) · BioDelivery Sciences International (2) · Duke University (2) · Enalare Therapeutics Inc. (2) · Environmental Protection Agency (EPA) (2) · KK Women's and Children's Hospital (2) · Oregon Health and Science University (2) · University of Alabama at Birmingham (2) · University of California, San Francisco (2) · Yale University (2) · Albert Einstein Healthcare Network (1) · Baylor College of Medicine (1) · Baylor Research Institute (1) · Başakşehir Çam & Sakura City Hospital (1) · Community Health System (1)
United States (28) · Canada (5) · China (5) · Singapore (3) · Turkey (Türkiye) (3) · France (2) · Netherlands (2) · Belgium (1) · Germany (1) · Ireland (1) · Israel (1) · Japan (1) · Norway (1) · South Korea (1) · Spain (1)
Susan J Dempsey, PhD(c) (2) · Alethia Sellers, MD (1) · Aymen Alian, MD (1) · Ban L Sng, FANZCA (1) · Ban Leong Sng, MBBS, MMED (1) · Brendan Carvalho, MD (1) · Christoph Seubert, MD PhD DABNM (1) · David Blum, MD (1) · David MacLeod, MB BS (1) · Dong-Xin Wang, MD, PhD (1) · Estomih R Mduma, Manager (1) · Francis F Chung, MBBS FRCPC (1) · Frank J Overdyk (1) · Gert Roncada, DO, MSc (1)
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R44DA057133 (1), UG3DA062506-02 (1)