37 completed, 12 unknown, 7 recruiting, 1 suspended. 44 Not applicable, 6 Phase 2, 5 Phase 3, 3 Phase 1, 2 Phase 4.
Follow this drug Literature Review of Ozone trials Research Report on Ozone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis ozone injection, Exercise - Knee Osteoarthritis | Not applicable | Recruiting | Kayseri City Hospital | 80 | 2025-11-19 | 2026-07-01 |
| Comparison of ESWT and Ultrasound-Guided Ozone Injection in Lateral Epicondylitis ESWT Device, ozone injection - Epicondylitis, Lateral | Not applicable | Recruiting | Ankara City Hospital Bilkent | 50 | 2025-06-01 | 2026-02-23 |
| Efficacy of Ozone Therapy in Reducing Complications Following Impacted Mandibular Third-molar Surgery Ozone, Placebo - Impacted Mandibular Third Molar Extraction | Phase 3 | Completed | Jelena Krunic | 20 | 2024-12-01 | 2026-06-08 |
| Investigating Changes in Responses to Controlled Effective Doses of Ozone at Different Exercise Intensities Ozone, Heavy Intensity, Moderate Intensity - Ozone, Exercise Intensity | Not applicable | Withdrawn | Michael Koehle | 2024-09-01 | 2025-03-30 | |
| Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief Dexmedetomidine, Ozone, Dexamethasone - Carpal Tunnel, Dexmedetomidine | Not applicable | Recruiting | Tanta University | 135 | 2023-11-01 | 2025-05-29 |
| The Effects of Ultrasound Guided Ozone and Lidocaine Injections in Piriformis Syndrome Ozone, Lidocain - Piriformis Syndrome | Not applicable | Unknown | Ankara City Hospital Bilkent | 28 | 2023-09-01 | 2023-11-14 |
| Dry Needling Versus Ozone in Myofascial Pain Syndrome Dry Needling, Ozone Injection - Dry Needling, Ozone | Not applicable | Unknown | Uskudar State Hospital | 90 | 2023-09-01 | 2023-08-16 |
| Macrophage Regulation of Ozone-Induced Lung Inflammation Ozone - Respiratory Viral Infection | Phase 1 | Recruiting | Robert Tighe, MD | 100 | 2023-05-18 | 2026-05-15 |
| Different Ozone Concentrations for Knee Osteoarthritis ozone injection - Knee Osteoarthristis, Gonarthrosis | Not applicable | Completed | Sakarya University | 159 | 2023-05-02 | 2026-06-23 |
| Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis Ozone injection - Knee Osteoarthritis | Not applicable | Completed | Uskudar State Hospital | 82 | 2023-04-21 | 2023-05-25 |
| The Role of Macrophage Activation in Lung Injury Following Ozone Exposure Clean Air, Ozone - Air Pollution | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 120 | 2023-02-07 | 2025-12-17 |
| Safe Use of New Technologies in Diabetes in Flight Hypobaric, Ground level - Type1 Diabetes | Not applicable | Completed | University of Surrey | 6 | 2023-01-28 | 2024-12-17 |
| Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis Ozone, Dextrose prolotherapy, Dexmedetomidine - Intraarticular, Ozone | Not applicable | Completed | Tanta University | 60 | 2022-10-01 | 2025-04-03 |
| Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise Exercise, Ozone, Room air - Ozone Exposure During Rest and Exercise | Not applicable | Completed | University of British Columbia | 20 | 2022-08-18 | 2025-04-13 |
| Efficacy of Local Anesthetic and Ozone Injection in Patients With Myofascial Pain Syndrome Lidocaine 2% Injectable Solution, Ozone, stretching exercise - Myofascial Pain Syndrome, Ozone | Not applicable | Unknown | Pamukkale University | 72 | 2022-06-30 | 2022-06-23 |
| Intra Articular Injection of Ozone With Corticosteroids vs PRGF in Knee Osteoarthritis Intra-articular Ozone and corticosteroids, intra-articular PRGF Method - Intra Articular Injection, Corticosteroids | Not applicable | Completed | Tanta University | 90 | 2022-06-01 | 2024-02-20 |
| Ozone Therapy in Patients With Diabetic Neuropathy Ozone, Convtrol group - Pain, Chronic | Not applicable | Unknown | Assiut University | 60 | 2022-02-25 | 2022-01-05 |
| Comparison of Subacromial Ozone (O2-O3) and Corticosteroid Injections in the Treatment of Rotator Cuff Tendinopathy Ozone (O2-O3) injection, Corticosteroid injection - Rotator Cuff Tendinopathy | Not applicable | Completed | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | 44 | 2022-01-27 | 2022-06-14 |
| Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB) Salbutamol, Placebo medication, Ozone - Asthma and/or Exercise Induced Bronchoconstriction, Ozone Air Pollution | Phase 4 | Completed | University of British Columbia | 18 | 2021-11-01 | 2025-03-14 |
| the Effect of Ozone Oil on the Postoperative Sequalae After Surgical Removal of Third Molar Ozone-Based Agent, Placebo - Impacted Third Molar Tooth | Phase 2 | Completed | University of Baghdad | 40 | 2021-03-21 | 2022-09-16 |
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Osteoarthritis, Knee (6) · Asthma (3) · Pain (3) · Carpal Tunnel Syndrome (2) · Chronic Pain (2) · Inflammation (2) · Myocardial Ischemia (2) · Myofascial Pain Syndromes (2) · Osteoarthritis (2) · Respiratory Aspiration (2) · Respiratory Insufficiency (2) · Asthma, Exercise-Induced (1) · Cardiovascular Diseases (1) · Chronic Periodontitis (1) · Cystitis, Interstitial (1)
University of North Carolina, Chapel Hill (6) · Environmental Protection Agency (EPA) (5) · Assiut University (4) · Robert Tighe, MD (3) · Tanta University (3) · University of British Columbia (3) · Ankara City Hospital Bilkent (2) · Bernardino Clavo, MD, PhD (2) · Izmir Katip Celebi University (2) · Kayseri City Hospital (2) · Rutgers, The State University of New Jersey (2) · Sakarya University (2) · Uskudar State Hospital (2) · Anhembi Morumbi University (1) · Ataturk University (1)
United States (17) · Turkey (Türkiye) (11) · Egypt (5) · Canada (4) · Brazil (3) · Italy (2) · Spain (2) · Bosnia and Herzegovina (1) · China (1) · Denmark (1) · Germany (1) · India (1) · Iraq (1) · United Kingdom (1)
David Diaz-Sanchez, PhD (3) · Robert Tighe, MD (3) · Bernardino Clavo, MD, PhD (2) · Michael Koehle, MD, PhD (2) · Pedro G Serrano-Aguilar, MD, PhD (2) · Anthony P Rozario, DNS,FRCS (1) · Berardo Di Matteo, MD, PhD (1) · Berke Aras, Medical Doctor (1) · Bilge Kesikburun, Ass. Prof (1) · Celestina Amador, MD, PhD (1) · Cristiano Sconza, MD (1) · Damla Torul, DDS PhD (1) · David B Peden, MD (1)
PMID 16198334, PMID 19260079, PMID 21427067, PMID 21575276, PMID 21751891, PMID 22430658, PMID 23102757, PMID 23549581, PMID 24687190, PMID 24733808, PMID 25089169, PMID 25178924, PMID 25699252, PMID 27790294, PMID 29777618, PMID 31779159, PMID 32024498, PMID 32379556, PMID 33738491, PMID 39446977, PMID 39496965, PMID 39521725, PMID 41246912
R01ES004738 (2), 2018 (1), 2019 (1), R01ES017428 (1), R01ES034350 (1)