30 completed, 4 suspended, 2 enrolling by invitation, 2 unknown. 26 Not applicable, 4 Phase 1, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 26 | Completed 19, Suspended 4, Unknown 2, Enrolling by invitation 1 |
| Phase 1 | 4 | Completed 3, Withdrawn 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest Ozone Exposure, Clean air (0.0 ppm ozone) - Lung Inflammation, Experimental Lung Inflammation | Not applicable | Enrolling by invitation | Environmental Protection Agency (EPA) | 40 | 2024-11-05 | 2025-04-27 |
| Efficacy of Respiratory Protection Against the Effects of Wood Smoke Exposure in Young Healthy Adults Filtration of all PM and VOC's, Filtration of VOC's - Healthy | Not applicable | Suspended | University of North Carolina, Chapel Hill | 50 | 2024-06-01 | 2025-06-12 |
| Craniofacial Dimensions as Determinants of the Fitted Performance of Common Face Masks (FACEFIT 2.0) Surgical/Procedure Mask Fit Testing, KN95 Mask Fit testing - Healthy | Not applicable | Suspended | University of North Carolina, Chapel Hill | 500 | 2024-05-30 | 2025-06-12 |
| Modification of Ambient Air Pollution Exposure and Cardiopulmonary Outcomes by Socioeconomic Status and Nutrition Air Pollution, Pollution; Exposure | Enrolling by invitation | Environmental Protection Agency (EPA) | 82 | 2023-08-21 | 2024-02-20 | |
| ASPIRE Health Tulare County DIY portable air cleaner with a highly effective filter, DIY portable air cleaner with sham filtration - Respiratory Tract Diseases, Cardiovascular Diseases | Not applicable | Unknown | Environmental Protection Agency (EPA) | 80 | 2023-07-29 | 2023-10-27 |
| The 3rd COPENHAGEN Puberty Study Puberty, Puberty, Precocious | Recruiting | Copenhagen University Hospital, Rigshospitalet | 3000 | 2023-01-01 | 2024-01-10 | |
| Variation In Facial Morphology As A Determinant Of Face Covering Performance: FACEFIT N95, KN95, KF94 - Healthy | Completed | University of North Carolina, Chapel Hill | 100 | 2022-06-01 | 2024-02-29 | |
| COVID-19 Antibody Levels After Vaccines COVID-19 Vaccination - Vaccine Preventable Disease | Completed | University of North Carolina, Chapel Hill | 71 | 2021-06-09 | 2022-08-01 | |
| Cardiovascular Effects of Exposure to Wood Smoke in Healthy Human Adults Filtered Air, Wood Smoke - Healthy | Not applicable | Suspended | University of North Carolina, Chapel Hill | 80 | 2021-05-25 | 2025-06-12 |
| Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ) Ozone, FA - Asthma, Allergic | Not applicable | Suspended | University of North Carolina, Chapel Hill | 18 | 2019-12-16 | 2025-12-17 |
| Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART) Clinical Center Reference Endotoxin (CCRE), Normal saline - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 15 | 2018-10-17 | 2019-09-20 |
| Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects Ozone, Fish Oil, Olive Oil - Healthy, Dietary Supplement | Phase 1 | Completed | University of North Carolina, Chapel Hill | 44 | 2017-12-18 | 2021-01-15 |
| Systemic Inflammatory Response to CCRE CCRE - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 25 | 2017-12-11 | 2019-09-20 |
| Human Biological Responses to Low Level Ozone Ozone, Filtered Air, Health and Exposure Tracker (HET) - Environmental Exposure, Nasal Inflammation | Not applicable | Completed | University of North Carolina, Chapel Hill | 15 | 2017-04-22 | 2021-05-14 |
| Responses to Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Adults Clean Air, PM2.5 - Exposure to Pollution | Not applicable | Completed | Environmental Protection Agency (EPA) | 20 | 2017-01-16 | 2021-09-05 |
| Effect of Commute Traffic on Vascular Function Filtered Air - Cardiovascular Diseases | Not applicable | Completed | University of Washington | 16 | 2015-01-01 | 2022-07-12 |
| The Interaction of Social Factors With Air Pollution Clean Air, Ozone - Exposure to Environmental Pollution, Non-occupational | Not applicable | Completed | Environmental Protection Agency (EPA) | 40 | 2014-07-01 | 2017-07-26 |
| Effects of Wood Smoke Particles on Influenza-induced Nasal Inflammation in Normal Volunteers wood smoke, clean air - Response of Viral Infection to Woodsmoke | Early Phase 1 | Completed | University of North Carolina, Chapel Hill | 39 | 2014-07-01 | 2015-06-11 |
| Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers. Ozone, Nitrogen dioxide - Respiratory Depression | Not applicable | Completed | Environmental Protection Agency (EPA) | 54 | 2014-01-01 | 2020-08-17 |
| Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers Clean air, Ozone - Exposure to Environmental Pollution, Non-occupational | Not applicable | Completed | Environmental Protection Agency (EPA) | 14 | 2013-12-01 | 2019-07-30 |
Showing 20 of 41. Sign in to see all of them.
Asthma (3) · COVID-19 (2) · Cardiovascular Diseases (2) · Inflammation (2) · Influenza, Human (2) · Neoplasms (2) · Poisoning (2) · Respiratory Insufficiency (2) · Allergic Fungal Sinusitis (1) · Lung Diseases (1) · Lymphoma (1) · Metabolic Syndrome (1) · Multiple Myeloma (1) · Nasal Polyps (1) · Obesity (1)
Ozone (11) · Environment, Controlled (7) · Endotoxins (2) · Fish Oils (2) · Olive Oil (2) · Surgical Procedures, Operative (2) · Vehicle Emissions (2) · 1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (1) · Fatty Acids, Omega-3 (1) · FluMist (1) · Lipopolysaccharides (1) · N95 Respirators (1) · Nitrogen Dioxide (1) · Particulate Matter (1) · Saline Solution (1)
United States (37) · Denmark (1)
James Samet, PhD (4) · David Diaz-Sanchez, PhD (3) · Michelle Hernandez, MD (3) · Terry Noah, MD (2) · Anders Juul, PhD, DMSc (1) · Andrew Murr, MD (1) · Ann N Chelminski, MD, MPH (1) · Arlene M Butz, ScD, RN (1) · Bradford Harris, MD (1) · Candice B Smith, PhD (1) · David B Peden, MD (1) · David B Peden, MD, MS (1) · David B. Peden, MD (1) · David Diaz-Sanchez, Ph.D. (1) · David Peden, MD (1)
PMID 21810636, PMID 22071326, PMID 22732313, PMID 25178924, PMID 26177651, PMID 26745856, PMID 27154411, PMID 27450419, PMID 30360637, PMID 33198760, PMID 34863138, PMID 37684282, PMID 38011704, PMID 39228845, PMID 41246912, PMID 41693548
R01ES013611 (2), K24ES013195 (1), P50ES015915 (1), R01ES012706 (1)