61 completed, 20 unknown, 5 recruiting, 5 terminated. 51 Not applicable, 6 Phase 4, 4 Phase 2, 2 Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Miniature In-line Respirator Hope inVent - Brain Death, Respiration, Artificial | Not applicable | Not yet recruiting | National Institutes of Health Clinical Center (CC) | 5 | 2026-11-08 | 2026-11-03 |
| VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU Respiration, Artificial, Positive-Pressure Respiration | Recruiting | Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva | 800 | 2026-09-07 | 2026-09-11 | |
| Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study Ventilator Weaning, Airway Extubation | Recruiting | Seoul National University Hospital | 50 | 2026-08-11 | 2026-08-18 | |
| A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score Ventilator Weaning, Respiration, Artificial | Recruiting | Medipol University | 470 | 2025-06-15 | 2026-05-05 | |
| High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Heart Defects, Congenital, Intensive Care Units, Pediatric | Not applicable | Recruiting | Universitas Indonesia | 114 | 2025-06-05 | 2025-07-11 |
| Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: a Multicenter Observational Study Respiration, Artificial, Noninvasive Ventilation | Enrolling by invitation | Argentinian Intensive Care Society | 246 | 2025-05-01 | 2025-05-31 | |
| Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study Changes in the ventilator respiratory rate and tidal volume - Respiration, Artificial, Reverse Triggering | Not applicable | Unknown | Unity Health Toronto | 30 | 2025-01-30 | 2025-05-20 |
| Optimal Timing for Spontaneous Breathing Trials Later Morning Timing of Spontaneous Breathing Trials - Respiration, Artificial, Weaning | Not applicable | Recruiting | Rush University Medical Center | 348 | 2024-09-17 | 2026-09-30 |
| Superiority Trial Between Sotair® Device Attached to Manual Resuscitator Versus Ventilation Alone Adult Sotair Device - Airway Management, Respiration, Artificial | Not applicable | Completed | Rhode Island Hospital | 30 | 2024-05-09 | 2026-07-21 |
| Brain Recovery With Automated VEntilation INTELLiVENT, Conventional ventilation - Brain Injuries, Acute, Respiration, Artificial | Completed | University of Genova | 20 | 2024-04-11 | 2026-03-10 | |
| Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation Breath synchronized abdominal FES, Sham breath synchronized abdominal FES - Respiration, Artificial, Ventilators, Mechanical | Not applicable | Completed | Liberate Medical | 250 | 2024-02-15 | 2026-06-02 |
| Non-inferiority Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation ADULT Sotair Device - Airway Management, Respiration, Artificial | Not applicable | Completed | Rhode Island Hospital | 334 | 2023-12-20 | 2026-11-02 |
| Association Between Tidal Volume and Mortality in Pressure Support in Adults Under Invasive Mechanical Ventilation high vs low tidal volume - Respiration, Artificial | Completed | Sanatorio Anchorena San Martin | 2607 | 2023-11-30 | 2025-05-15 | |
| Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients Music Therapy - Sedation, Critical Illness | Not applicable | Completed | University of Oviedo | 110 | 2023-10-14 | 2026-03-25 |
| Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction Parasternal Intercostal Ultrasound and RSBI Assessment - Respiratory Insufficiency, Weaning, Ventilator | Not applicable | Completed | Benha University | 50 | 2023-10-03 | 2025-08-28 |
| Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure Spontaneous mode of mechanical ventilation - Respiration, Artificial, Acute Hypoxemic Respiratory Failure | Completed | University of Sao Paulo General Hospital | 431 | 2023-06-12 | 2026-10-13 | |
| Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19 Respiratory Mechanics, Respiration, Artificial | Completed | Hospital Donación Francisco Santojanni | 110 | 2023-02-10 | 2023-07-14 | |
| Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation Placement of nasogastric balloon - Respiratory Muscles, Respiration, Artificial | Not applicable | Unknown | University Hospital, Antwerp | 150 | 2022-09-21 | 2025-04-06 |
| Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH) Telehealth- enabled support for SAT/SBT adherence, Usual audit and feedback for SAT/SBT adherence - Respiration, Artificial | Not applicable | Unknown | Intermountain Health Care, Inc. | 13400 | 2022-09-01 | 2023-07-03 |
| Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles - Ventilator Weaning, Respiration, Artificial | Not applicable | Completed | University Hospital, Antwerp | 1 | 2022-06-15 | 2025-04-04 |
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Respiratory Aspiration (96) · Respiratory Insufficiency (13) · Critical Illness (11) · Respiratory Distress Syndrome (5) · Postoperative Complications (3) · Brain Death (2) · COVID-19 (2) · Delirium (2) · Neuromuscular Diseases (2) · Premature Birth (2) · Ventilator-Induced Lung Injury (2) · Acute Kidney Injury (1) · Alcoholism (1) · Aortic Aneurysm, Thoracoabdominal (1) · Brain Injuries (1)
Pathologic Processes (96) · Pathological Conditions, Signs and Symptoms (96) · Respiration Disorders (96) · Respiratory Tract Diseases (96) · Disease Attributes (12) · Nervous System Diseases (11) · Lung Diseases (10) · Neurologic Manifestations (7) · Mental Disorders (6) · Signs and Symptoms (6) · Infections (4) · Neurobehavioral Manifestations (4) · Behavior (3) · Brain Diseases (3) · Central Nervous System Diseases (3)
Dexmedetomidine (2) · Interactive Ventilatory Support (2) · Propofol (2) · Administration, Inhalation (1) · Blood Gas Analysis (1) · Clonidine (1) · Critical Care (1) · Electric Stimulation (1) · Haloperidol (1) · Heparin (1) · Hydroxyethyl Starch Derivatives (1) · Midazolam (1) · Music Therapy (1) · Noninvasive Ventilation (1) · Oxygen (1)
Hospital de Clinicas de Porto Alegre (3) · Sanatorio Anchorena San Martin (3) · University Hospital, Antwerp (3) · Argentinian Intensive Care Society (2) · Children's Hospital of Philadelphia (2) · Liberate Medical (2) · Massachusetts General Hospital (2) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · Respinor AS (2) · Rhode Island Hospital (2) · Tufts Medical Center (2) · Unity Health Toronto (2) · Universidade Federal Fluminense (2) · University Hospital, Caen (2) · University Medical Center Groningen (2)
United States (21) · France (11) · Brazil (10) · Italy (10) · Argentina (8) · Canada (7) · Netherlands (5) · Spain (5) · Belgium (4) · China (4) · Chile (3) · Norway (3) · Denmark (2) · Egypt (2) · Germany (2)
Gustavo Plotnikow, RT (2) · Mark Kendall, MD (2) · Palle Toft, Professor (2) · Alexandre Demoule, MD (1) · Alparslan Turan, M.D. (1) · Andrea Ventura, MSC, MD (1) · Andreas Greinacher, MD (1) · Andrew J Mannes, M.D. (1) · Angus Mclachlan, PhD (1) · Anne F Klenner, MD (1) · Annop Piriyapatsom, MD (1) · Avelino C Verceles, MD,MS (1)
PMID 10816184, PMID 18191684, PMID 23631814, PMID 10793162, PMID 17470624, PMID 26903337, PMID 27626706, PMID 30113379, PMID 33332819, PMID 39014512, PMID 7823995, PMID 9279224, PMID 10379020, PMID 10390410, PMID 10491448, PMID 11790214, PMID 12243491, PMID 14525802, PMID 14595568, PMID 15187505, PMID 15343007, PMID 15713907, PMID 16424706, PMID 16424709, PMID 16625136, PMID 16799075, PMID 17575489, PMID 18434907, PMID 18619805, PMID 18636057, PMID 18949178, PMID 19232208, PMID 19454032, PMID 19857731, PMID 20116842, PMID 20299535, PMID 20352189, PMID 20397343, PMID 20409628, PMID 21156950, PMID 21168440, PMID 21169829, PMID 21276316, PMID 21333087, PMID 21402326, PMID 21422364, PMID 21542927, PMID 21596879, PMID 22008396, PMID 22166673
2018 (1), K23AG001023 (1), M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), R03AG045100 (1), U01HD019897 (1), U01HL159878 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1), U10HD021415 (1)