15 completed, 5 unknown, 2 recruiting, 1 active not recruiting. 6 Not applicable, 4 Phase 1, 3 Phase 4, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 5, Unknown 1 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 4 | 3 | Active not recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Reflux: new trials by email Literature Review of Reflux trials Research Report on Reflux
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Mechanism Versus PPI Trial Omeprazole 40 MG, Laryngeal Recalibration Therapy, GERD Lifestyle Recommendations - Laryngopharyngeal Reflux, Cough | Phase 4 | Recruiting | University of California, San Diego | 160 | 2025-06-04 | 2025-08-01 |
| Primary carE PPi dEprescRibing Trial de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate - Heartburn, Dyspepsia | Phase 4 | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 724 | 2023-05-12 | 2025-01-31 |
| Role of ARMA in Selective Subset of Refractory GERD Patients. ARMA, UGI Endoscopy - GERD, Reflux | Not applicable | Completed | Asian Institute of Gastroenterology, India | 50 | 2023-03-30 | 2025-04-04 |
| Protocol for the ESREFLUJO Study: Epidemiological Study of Heartburn and Gastroesophageal Reflux in Community Pharmacy Reflux | Unknown | Universidad Miguel Hernandez de Elche | 1200 | 2022-03-01 | 2021-12-17 | |
| Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study Endoscopic Surgery - Achalasia, Gastric Outlet Obstruction | Unknown | Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University | 5000 | 2021-02-17 | 2023-05-26 | |
| Mechanism of Weight Loss After Endoscopic and Laparoscopic Sleeve Procedures Metabolic and Hormonal profile - Weight Loss, Reflux | Terminated | Northwell Health | 4 | 2019-07-01 | 2022-02-14 | |
| The Role of Laryngopharyngeal Reflux in IPF IPF, Reflux | Recruiting | National Jewish Health | 60 | 2018-08-01 | 2024-11-14 | |
| Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Polidocanol Endovenous Microfoam (PEM) - Leg Ulcer, Veins, Varicose | Phase 4 | Withdrawn | OhioHealth | 2017-04-10 | 2017-09-15 | |
| Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? Quercetin - Gastroesophageal Reflux Disease, GERD | Phase 1 | Completed | University of North Carolina, Chapel Hill | 26 | 2014-08-01 | 2016-12-20 |
| Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists Laryngitis, Reflux | Completed | Chuncheon Sacred Heart Hospital | 21 | 2014-01-01 | 2014-04-07 | |
| Efficacy of a Dietary Supplementation With Lactobacillus Reuteri for Digestive Health in an Elderly Population Placebo, Lactobacillus reuteri DSM 17938 - Constipation, Diarrhea | Phase 3 | Completed | Örebro University, Sweden | 290 | 2013-04-01 | 2014-12-05 |
| HEP-FYN 12-Years Follow-up 13C-Urea breath test for Helicobacter Pylori, Questionaire - Peptic Ulcer, Dyspepsia | Not applicable | Unknown | Odense University Hospital | 10000 | 2012-03-01 | 2014-11-20 |
| RESULT (REflux Surgery in Lung Transplantation) Preliminary Study Protocol Reflux, Gastroesophageal Reflux Disease (GERD) | Completed | Duke University | 647 | 2011-09-01 | 2014-09-12 | |
| Cough Monitoring Study Cough, Reflux | Completed | Vanderbilt University | 33 | 2010-11-01 | 2015-06-08 | |
| Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects AZD2516, 5 mg, AZD2516, 16 mg, AZD2516, 40 mg - Reflux | Phase 2 | Completed | AstraZeneca | 20 | 2010-05-01 | 2012-08-30 |
| On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus. Esomeprazole 40mg, Esomeprazole - Barrett Esophagus, Proton Pump Inhibitor | Not applicable | Completed | Kaohsiung Veterans General Hospital. | 218 | 2010-02-02 | 2020-04-03 |
| Prospective Randomized Trial Evaluating the Utility of Esophageal Stitches During Laparoscopic Fundoplication esophageal stitches during fundoplication, no esophageal stitches placed during fundoplication - Reflux | Not applicable | Completed | Children's Mercy Hospital Kansas City | 65 | 2010-02-01 | 2017-01-26 |
| Renal Impairment Study AZD3355 - Reflux, Renal Excretion | Phase 1 | Completed | AstraZeneca | 23 | 2009-03-01 | 2011-01-24 |
| Evaluation Study of a Management Strategy for Gastroesophageal Reflux Disease (GERD) Reflux, Heartburn | Completed | AstraZeneca | 2370 | 2009-01-01 | 2009-12-23 | |
| Do Patients Who Have Had Surgery for Achalasia Suffer From Reflux pH study - Reflux | Not applicable | Completed | Kenneth Luberice | 100 | 2007-06-01 | 2012-08-15 |
Showing 20 of 25. Sign in to see all of them.
Gastroesophageal Reflux (25) · Dyspepsia (4) · Esophagitis (3) · Heartburn (3) · Barrett Esophagus (2) · Cough (2) · Esophageal Achalasia (2) · Peptic Ulcer (2) · Abdominal Abscess (1) · Abdominal Pain (1) · Acidosis (1) · Chronic Cough (1) · Constipation (1) · Diarrhea (1) · Dysphonia (1)
Deglutition Disorders (25) · Digestive System Diseases (25) · Esophageal Diseases (25) · Esophageal Motility Disorders (25) · Gastrointestinal Diseases (25) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Signs and Symptoms, Digestive (6) · Gastroenteritis (4) · Stomach Diseases (4) · Duodenal Diseases (3) · Intestinal Diseases (3) · Neurologic Manifestations (3) · Respiratory Tract Diseases (3) · Body Weight (2)
Esomeprazole (3) · Alginates (1) · Endoscopy (1) · Lansoprazole (1) · Metabolic Networks and Pathways (1) · Omeprazole (1) · Pantoprazole (1) · Pharmaceutical Preparations (1) · Polidocanol (1) · Quercetin (1) · Ringer's Lactate (1) · lesogaberan (1) · tetrachloroisophthalonitrile (1)
AstraZeneca (4) · Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University (1) · Asian Institute of Gastroenterology, India (1) · Children's Mercy Hospital Kansas City (1) · Chuncheon Sacred Heart Hospital (1) · Duke University (1) · Kaohsiung Veterans General Hospital. (1) · Kenneth Luberice (1) · Main Line Health (1) · National Jewish Health (1) · Northwell Health (1) · Odense University Hospital (1) · OhioHealth (1) · Takeda (1) · Tel-Aviv Sourasky Medical Center (1)
United States (11) · Sweden (3) · Belgium (2) · Austria (1) · Canada (1) · India (1) · Israel (1) · Italy (1) · Netherlands (1) · Norway (1) · Spain (1)
Andrei Keidar, MD (1) · Digvijay Chavan (1) · Dong Kyu Kim, MD (1) · Idit Matot, MD (1) · James M Mullin, Ph.D. (1) · Lynne Durborow (1) · Mark Berner Hansen (1) · Marta Illueca (1) · Matthew Koslow, DO (1) · Mattijs E Numans, MD, PhD (1) · Michael Vaezi, MD, PhD (1) · Michel Kahaleh, MD (1) · Neeraj Singla, MD (1)
PMID 22510027, PMID 23426452, PMID 26492842, PMID 27612653, PMID 27875488, PMID 28606845, PMID 32010745, PMID 34754155, PMID 35947304, PMID 35997700, PMID 36011453, PMID 36109362, PMID 39713795, PMID 41997699
R01DK139089 (1), R21DK097529 (1), R34HL105422 (1)