14 completed, 7 unknown, 3 terminated, 2 not yet recruiting. 11 Not applicable, 9 Phase 4, 4 Phase 2, 2 Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser - Telangiectasias, Reticular Veins | Phase 4 | Recruiting | University of Sao Paulo | 70 | 2026-09-01 | 2026-10-05 |
| Polidocanol 1% and Steroid in Keloids and Hypertrophic Scars Group 1 (polidocanol 1% group):, Group 2 (Triamcinolone acetonide group):, Group 3 (combined Triamcinolone acetonide and polidocanol 1% group): - Keloid and Hypertrophic Scars | Not applicable | Not yet recruiting | Sohag University | 90 | 2026-08-01 | 2026-05-26 |
| Outcomes of Different Treatment Options in Chronic Venous Disease Radiofrequency ablation using Closure fast, Aethoxysclerol, Daflon - Chronic Venous Disease | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 2000 | 2024-07-01 | 2024-06-28 | |
| Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas Deoxycholic Acid, Polidocanol, 1064nm Nd:YAG laser - Neurofibromatosis 1 | Phase 1 | Completed | Massachusetts General Hospital | 13 | 2024-03-01 | 2025-11-21 |
| A Comparison of Flexible Endoscopic Polidocanol Liquid and Foam Sclerotherapy in Cirrhotic Patients With Bleeding From Internal Hemorrhoids Sclerotherapy with 1.5% polidocanol, Foam sclerotherapy. - Liver Cirrhosis, Internal Hemorrhoid | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 60 | 2023-09-07 | 2023-09-15 |
| Comparative Study of Polidocanol and Absolute Alcohol for Percutaneous us Guided Treatment of Benign Thyroid Cyst Polidocanol, Alcohol - Benign Thyroid Nodule, Thyroid Lump | Phase 4 | Unknown | Assiut University | 30 | 2023-04-01 | 2023-04-05 |
| Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS) Varithena®, FDA-approved Endothermal Ablation (ETA) systems - Varicose Veins | Phase 4 | Terminated | Boston Scientific Corporation | 43 | 2023-02-10 | 2026-03-20 |
| Dosing and Tolerability of Deoxycholic Acid vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas Kybella, Asclera - Neurofibromatosis 1 | Phase 1 | Completed | Massachusetts General Hospital | 20 | 2022-12-06 | 2025-02-21 |
| Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections Polidocanol - Venous Reflux, Venous Insufficiency | Not applicable | Unknown | ProMedica Health System | 30 | 2020-09-30 | 2022-12-01 |
| Intralesional Sclerosant for in Transit and Cutaneous Melanoma Metastases Polidocanol Injection - Melanoma, In-Transit Metastasis of Cutaneous Melanoma | Phase 2 | Withdrawn | Melanoma Institute Australia | 2020-05-20 | 2022-07-14 | |
| A Safety and Tolerability Study of 10XB-101 Injections in Adult Subjects With Extra Fat Under the Chin ("Double Chin") 10XB-101 Solution for Injection - Submental Fat | Phase 2 | Completed | 10xBio, LLC | 15 | 2019-10-10 | 2024-04-10 |
| Treatment of Venous Malformation Direct Puncture Repair / Ethanol, Direct Puncture Repair / Polidocanol - Venous Malformation | Not applicable | Completed | Al-Azhar University | 20 | 2018-10-01 | 2022-10-19 |
| Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU) Varithena - Venous Leg Ulcer | Completed | Boston Scientific Corporation | 76 | 2017-09-29 | 2021-12-14 | |
| Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Polidocanol Endovenous Microfoam (PEM) - Leg Ulcer, Veins, Varicose | Phase 4 | Withdrawn | OhioHealth | 2017-04-10 | 2017-09-15 | |
| Pilot RCT Evaluating a One Stop Vein Clinic One Stop Vein Clinic, Radiofrequency ablation, Endovenous laser ablation - Varicose Veins | Not applicable | Terminated | Imperial College London | 3 | 2015-10-01 | 2025-05-16 |
| An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst polidocanol, infra-red coagulation, cryotherapy - Ganglion Cysts | Phase 4 | Terminated | University of Edinburgh | 10 | 2015-07-27 | 2024-05-30 |
| Secondary Prophylaxis of Gastric Variceal Bleed Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate - Gastric Varices | Not applicable | Completed | West China Hospital | 64 | 2015-06-01 | 2019-01-08 |
| Acute Gastric Variceal Bleeding: Endoscopic Treatment Versus BRTO Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate - Gastric Varices | Not applicable | Unknown | West China Hospital | 70 | 2015-06-01 | 2019-01-08 |
| Primary Prophylaxis of Gastric Variceal Bleed Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate - Gastric Varices | Not applicable | Unknown | West China Hospital | 70 | 2015-06-01 | 2021-11-23 |
| COMFORT: A Multicenter, Open-label, Randomized, Crossover Study Varithena®, Radiofrequency ablation - Varicose Veins | Phase 4 | Completed | Boston Scientific Corporation | 35 | 2015-05-01 | 2021-04-21 |
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Varicose Veins (9) · Esophageal and Gastric Varices (4) · Varicose Ulcer (3) · Venous Insufficiency (3) · Gastroesophageal Reflux (2) · Neurofibromatosis 1 (2) · Telangiectasis (2) · Ulcer (2) · Cicatrix, Hypertrophic (1) · Foramen Ovale, Patent (1) · Ganglion Cysts (1) · Hyperpigmentation (1) · Hypersensitivity (1) · Hypertension, Portal (1) · Infections (1)
Boston Scientific Corporation (4) · West China Hospital (3) · Massachusetts General Hospital (2) · UPECLIN HC FM Botucatu Unesp (2) · 10xBio, LLC (1) · Al-Azhar University (1) · Assiut University (1) · Hannover Medical School (1) · Imperial College London (1) · Institute of Liver and Biliary Sciences, India (1) · Melanoma Institute Australia (1) · Northern Orthopaedic Division, Denmark (1) · OhioHealth (1) · ProMedica Health System (1) · Shanghai Zhongshan Hospital (1)
United States (9) · China (4) · Brazil (3) · United Kingdom (3) · Egypt (2) · Australia (1) · Canada (1) · Denmark (1) · France (1) · Germany (1) · India (1) · Norway (1) · Sweden (1)
Richard R Anderson, MD (2) · Christopher T Lee, MPharm (1) · David Wright, MD (1) · Diona Damian (1) · Fedor Lurie, PhD, MD (1) · Janet Rush, MD (1) · Jian-Mei Li, MBBS MD PhD (1) · Jihad Abbas, MD (1) · John Dobak, MD (1) · Karsten Knobloch, MD (1) · Mark S Whiteley, MS (1) · Matheus Bertanha, Dr (1)