49 completed, 36 unknown, 23 recruiting, 9 terminated. 72 Not applicable, 10 Phase 2, 7 Phase 3, 7 Phase 4, 2 Phase 1.
Follow Esophageal Achalasia: new trials by email Literature Review of Esophageal Achalasia trials Research Report on Esophageal Achalasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Disposable Endoscope Platform in Third Space Endoscopic Procedures (Esophageal or Gastric) Per-Oral Endoscopic Myotomy - Achalasia, Gastroparesis | Withdrawn | Baylor College of Medicine | 2026-12-30 | 2026-10-01 | ||
| PREcision MEDicine In Achalasia (PREMEDIA) - Cohort Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features | Recruiting | Northwestern University | 200 | 2026-12-01 | 2026-10-13 | |
| POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication - Esophageal Achalasia, Esophageal Motility Disorders | Not applicable | Recruiting | Minia University | 220 | 2026-09-20 | 2026-09-22 |
| Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions EndoFlip - Dysphagia, Esophageal Stricture | Not applicable | Recruiting | Johns Hopkins University | 25 | 2026-07-24 | 2026-08-24 |
| Short Versus Long Submucosal Tunneling in Per-oral Endoscopic Myotomy (POEM) for Type II Achalasia. per-oral endoscopic myotomy - Esophageal Achalasia | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-06-28 | 2026-07-07 |
| Biological Optimization Versus Standard Care in Post-POEM Achalasia Patients (BIO-POEM) Structured Biological Optimization - Achalasia Cardia, GERD (Gastroesophageal Reflux Disease) | Not applicable | Active not recruiting | Asian Institute of Gastroenterology, India | 166 | 2026-05-20 | 2026-06-02 |
| PREcision MEDicine In Achalasia (PREMEDIA) Standard Myotomy, Tailored Short Myotomy - Type I Achalasia, Type II Achalasia | Phase 3 | Recruiting | Northwestern University | 372 | 2026-04-29 | 2026-10-13 |
| PRospective Registry of Esophageal Motility No intervention - Esophageal Diseases, Achalasia | Recruiting | IRCCS San Raffaele | 10000 | 2026-03-09 | 2026-04-02 | |
| Transverse vs Longitudinal Mucosal Incision During POEM Transverse Mucosal Incision During POEM, Longitudinal Mucosal Incision During POEM - Esophageal Achalasia, Spastic Esophageal Motility Disorders | Phase 3 | Not yet recruiting | Universidad Nacional de Colombia | 140 | 2026-02-22 | 2026-02-24 |
| Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures AI generated segmentation mask for sub-mucosal blood vessels - Achalasia Cardia, Tumor | Not applicable | Completed | Asian Institute of Gastroenterology, India | 40 | 2026-02-10 | 2026-09-22 |
| Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM) Esophageal Motility Disorders, Achalasia | Recruiting | Baylor College of Medicine | 40 | 2026-01-15 | 2026-06-17 | |
| Metabolic Changes Associated With Weight Gain After Treatment of Achalasia Achalasia, Esophageal | Not yet recruiting | Assaf-Harofeh Medical Center | 30 | 2026-01-15 | 2026-01-13 | |
| Comparative Study of Per-oral Endoscopic Myotomy (POEM) in Treatment - naïve Achalasia Patients Versus Patients With Previous Pneumatic Dilation per-oral endoscopic myotomy (POEM) - Achalasia, Esophageal | Not applicable | Not yet recruiting | Assiut University | 32 | 2025-12-15 | 2025-12-17 |
| Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD Conventional POEM, Sling Fiber-Preserving POEM - Achalasia, Esophageal, GERD (Gastroesophageal Reflux Disease) | Not applicable | Not yet recruiting | University of California, Irvine | 120 | 2025-12-01 | 2025-10-22 |
| Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia POEM, BALLOON DILATATION - Achalasia Cardia | Not applicable | Not yet recruiting | Asian Institute of Gastroenterology, India | 70 | 2025-09-03 | 2025-09-11 |
| Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial Full thickness myotomy, Progressive thickness myotomy - Achalasia Cardia, Achalasia | Phase 2 | Recruiting | Cairo University | 70 | 2025-08-01 | 2026-10-15 |
| INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE achalasia treatments - Achalasia Cardia, Esophageal Cancer (EsC) | Active not recruiting | IRCCS San Raffaele | 47000 | 2025-06-03 | 2025-07-30 | |
| Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy Botulinum Toxin A (Botox ), Pyloromyotomy - Esophageal Cancer Surgery, Esophagectomy | Phase 2 / Phase 3 | Recruiting | The Cleveland Clinic | 170 | 2024-12-03 | 2026-02-25 |
| The Impact of Anesthetics on FLIP FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation. - Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction | Not applicable | Enrolling by invitation | Baylor Research Institute | 30 | 2024-11-22 | 2026-03-09 |
| Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM SpydrBlade Flex - Achalasia, EGJ Outflow Obstruction | Not applicable | Recruiting | Chinese University of Hong Kong | 73 | 2024-11-01 | 2026-02-12 |
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Deglutition Disorders (18) · Gastroesophageal Reflux (17) · Esophageal Motility Disorders (9) · Gastroparesis (6) · Esophageal Diseases (5) · Esophageal Spasm, Diffuse (4) · Esophageal Neoplasms (3) · Eosinophilic Esophagitis (2) · Esophagitis (2) · Fistula (2) · Gastric Outlet Obstruction (2) · Hernia, Hiatal (2) · Neoplasms (2) · Obesity (2)
Digestive System Diseases (139) · Gastrointestinal Diseases (138) · Esophageal Diseases (134) · Esophageal Motility Disorders (130) · Deglutition Disorders (121) · Otorhinolaryngologic Diseases (19) · Pharyngeal Diseases (18) · Pathological Conditions, Signs and Symptoms (17) · Signs and Symptoms (13) · Neurologic Manifestations (10) · Stomach Diseases (9) · Gastroenteritis (7) · Neoplasms (6) · Paralysis (6) · Pathological Conditions, Anatomical (6)
Heller Myotomy (6) · Botulinum Toxins, Type A (3) · Endoscopy (3) · nephronectin (3) · Anesthesia, General (2) · Laparoscopy (2) · Pyloromyotomy (2) · Receptors, Opioid, delta (2) · Saline Solution (2) · 1-palmitoyl-2-oleoylphosphatidylethanolamine (1) · Adrenal Cortex Hormones (1) · Amyl Nitrite (1) · Anti-Bacterial Agents (1) · Biopsy (1) · Blood Specimen Collection (1)
Asian Institute of Gastroenterology, India (7) · Shanghai Zhongshan Hospital (6) · Baylor College of Medicine (5) · Chinese University of Hong Kong (5) · Johns Hopkins University (5) · Mayo Clinic (5) · Northwestern University (5) · Peking Union Medical College Hospital (3) · Universitätsklinikum Hamburg-Eppendorf (3) · Vanderbilt University Medical Center (3) · Asan Medical Center (2) · Assiut University (2) · Baylor Research Institute (2) · Cairo University (2) · Federico II University (2)
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Ping-Hong Zhou, MD,PhD (3) · Antoine Debourdeau (2) · Hon Chi Yip, FRCSEd (2) · Karthik Ravi, MD (2) · Mohamed Othman, MD (2) · Thomas Roesch, Prof. Dr. (2) · Xiangbin Xing, MD, PhD (2) · Abhishek Tyagi (1) · Albert Jan Bredenoord, MD, PhD, Prof (1) · Alessandro Repici, MD (1) · Alexander S Rosemurgy, MD (1) · Anand Jain, MD (1) · Anders Thorell, Professor (1)
PMID 20354937, PMID 22068665, PMID 22609984, PMID 1451966, PMID 23665071, PMID 25469569, PMID 27609778, PMID 11413123, PMID 11709516, PMID 11789770, PMID 12010876, PMID 12730729, PMID 1417178, PMID 15273542, PMID 15633138, PMID 15836451, PMID 15930992, PMID 1593914, PMID 16538107, PMID 16675239, PMID 16722998, PMID 17090769, PMID 17440784, PMID 17703382, PMID 18722376, PMID 19028319, PMID 19072391, PMID 19106675, PMID 19453516, PMID 19911238, PMID 20955445, PMID 21111876, PMID 22562023, PMID 23007004, PMID 23043852, PMID 23054897, PMID 23105999, PMID 23394838, PMID 23549760, PMID 23581563, PMID 23871090, PMID 23877351, PMID 23891074, PMID 23973923, PMID 24074429, PMID 24232052, PMID 24282373, PMID 24362953, PMID 24892729, PMID 25088923
K23DK131317 (1), R03DK145962 (1)