Diarrhea: Clinical Trials

488 completed, 89 unknown, 56 terminated, 32 recruiting. 260 Not applicable, 144 Phase 2, 130 Phase 3, 69 Phase 4, 61 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	260	Completed 177, Unknown 34, Terminated 16, Recruiting 13, Active not recruiting 8, Not yet recruiting 7, Withdrawn 3, Enrolling by invitation 2
Phase 2	144	Completed 91, Terminated 19, Unknown 14, Recruiting 7, Withdrawn 7, Not yet recruiting 3, Active not recruiting 2, Suspended 1
Phase 3	130	Completed 95, Terminated 13, Unknown 12, Withdrawn 7, Recruiting 2, Suspended 1
Phase 4	69	Completed 50, Unknown 8, Terminated 4, Withdrawn 3, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1
Phase 1	61	Completed 45, Recruiting 4, Terminated 4, Unknown 3, Not yet recruiting 2, Withdrawn 2, Active not recruiting 1
Early Phase 1	6	Completed 2, Not yet recruiting 2, Recruiting 1, Terminated 1

Follow Diarrhea: new trials by email Literature Review of Diarrhea trials Research Report on Diarrhea

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Impact Evaluation of Accelerating Climate-Resilient Water, Sanitation and Hygiene Services for Schools and Healthcare Facilities in Karamoja Climate-resilient school WASH infrastructure package, WASH and menstrual health capacity building and social and behaviour change package - Diarrhea, Respiratory Tract Infections (RTI)	Not applicable	Recruiting	Elijah Kipchumba	16380	2026-10-19	2026-09-16
Rural Water Filtration and Health Study Water filter - Diarrhea, Enteric Pathogens	Not applicable	Not yet recruiting	Virginia Polytechnic Institute and State University	1584	2026-09-01	2026-09-14
Rash & Diarrhea Prophylaxis With Capivasertib Capivasertib, Loperamide, Fulvestrant - Metastatic HR+/HER2- Breast Cancer	Phase 2	Recruiting	Maryam Lustberg	108	2026-08-15	2026-07-29
Vedolizumab for the Prevention of ICI Related Diarrhea or Colitis in Patients With Cancer Vedolizumab, Placebo - IrAE, Immune-related Adverse Event	Phase 2 / Phase 3	Recruiting	AHS Cancer Control Alberta	36	2026-08-13	2026-08-27
GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity GLP-1 receptor agonist therapy - Morbid Obesity, Anorectal Diseases		Not yet recruiting	Gazi University	100	2026-08-01	2026-06-25
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns step-by-step parent education, active father participation in breastfeeding support - Prematurity, Low Birth Weight	Not applicable	Active not recruiting	Taipei Medical University Shuang Ho Hospital	80	2026-08-01	2026-09-22
Safety of Lactobacillus LB Postbiotic in Immunocompromised Paediatric Patients With Diarrhoeal Disease Lactobacillus LB - Diarrhea	Phase 1 / Phase 2	Not yet recruiting	Hospital Infantil de Mexico Federico Gomez	30	2026-07-13	2026-08-11
Bristol Stool Scale-Based Care Pathway for Enteral Nutrition-Associated Diarrhea in Critically Ill Patients BSFS-Based Diarrhea Care Pathway, Routine ICU Enteral Nutrition Care - Critical Illness, Diarrhea	Not applicable	Not yet recruiting	Tang-Du Hospital	60	2026-06-15	2026-07-06
Improved Child Nutrition and Development Through Social Transfers Social Transfer - Breastfeeding, Breastfeeding Education	Not applicable	Not yet recruiting	Swiss Tropical & Public Health Institute	1040	2026-06-01	2026-05-06
A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health Essential Fibre+ - Gut Health, Microbiome	Not applicable	Active not recruiting	Artah Nutrition Limited	50	2026-06-01	2026-08-24
Evaluating In-line Chlorination in Nigeria In-line Chlorination (ILC) with Behavioral Change Communication (BCC) - Diarrhea, Water Quality	Not applicable	Not yet recruiting	University of California, Berkeley	2655	2026-05-26	2026-05-22
Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis Gastroenteritis Acute, Dehydration		Recruiting	Aydin Adnan Menderes University	180	2026-05-15	2026-05-28
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D) LY3537031, Placebo - Irritable Bowel Syndrome, Diarrhea	Phase 2	Recruiting	Eli Lilly and Company	531	2026-05-06	2026-10-08
The Utility and Feasibility of Accessible Diarrhea Etiology Prediction Tool (ADEPT) in an Informal Healthcare Setting Diagnostic test: Accessible Diarrhea Etiology Prediction Tool (ADEPT) - Diarrhea Infectious, Algorithms	Not applicable	Completed	Daniel Leung	30	2026-04-12	2026-10-08
A Post-marketing Observational Study of Oral Cholera Vaccine Recombinant subunit B/bacterial cholera vaccine (enteric-coated capsules), Placebo - Diarrhea	Phase 4	Enrolling by invitation	Shanghai United Cell Biotechnology Co., Ltd	6000	2026-04-10	2026-07-10
The Impact of Shigellosis and Recommended Treatment in Children Azithromycin, Placebo - Diarrhea Infectious, Shigella	Phase 2	Recruiting	Johns Hopkins Bloomberg School of Public Health	700	2026-03-18	2026-03-30
Randomized, Blinded, Placebo-Controlled Evaluation of BioAmicus Complete BioAmicus Complete, Placebo - Infantile Colics, Constipation	Not applicable	Recruiting	NovoNatum Ltd	140	2026-03-16	2026-05-11
The Auxiliary Effect of Artificial Intelligence in the Detection of Precancerous Lesions in Proximal Colon Cancer AI group, Serial group, Standard colonoscopy group - Abdominal Pain, Black Stools		Not yet recruiting	Limian Er	1200	2026-02-26	2026-01-14
Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea Rifaximin 200 mg Tablet, Oral Rehydration Therapy (ORT) - Diarrhea, Gastroenteritis	Phase 4	Recruiting	Bausch Health Americas, Inc.	54	2026-02-11	2026-08-13
Impact of B. Adolescentis iVS-1 Probiotic on Gastrointestinal Outcomes Probiotic, Placebo - Digestive Disease, Gut Health	Not applicable	Completed	Synbiotic Health	92	2026-01-20	2026-10-19

Showing 20 of 719. Sign in to see all of them.

Narrower conditions

Irritable Bowel Syndrome (66)  ·  Constipation (61)  ·  Abdominal Pain (55)  ·  Gastroenteritis (34)  ·  Pneumonia (34)  ·  Clostridium Infections (32)  ·  Diarrhea, Infantile (26)  ·  Malaria (25)  ·  Malnutrition (25)  ·  Vomiting (23)  ·  Respiratory Tract Infections (21)  ·  Acquired Immunodeficiency Syndrome (20)  ·  HIV Infections (20)  ·  Cholera (18)

Broader conditions

Pathological Conditions, Signs and Symptoms (719)  ·  Signs and Symptoms (719)  ·  Signs and Symptoms, Digestive (715)  ·  Digestive System Diseases (227)  ·  Gastrointestinal Diseases (216)  ·  Infections (213)  ·  Intestinal Diseases (168)  ·  Bacterial Infections and Mycoses (94)  ·  Colonic Diseases (94)  ·  Pathologic Processes (86)  ·  Bacterial Infections (80)  ·  Respiratory Tract Diseases (77)  ·  Nutritional and Metabolic Diseases (72)  ·  Neurologic Manifestations (71)  ·  Gastroenteritis (64)

Interventions

Probiotics (32)  ·  Zinc (21)  ·  Rifaximin (18)  ·  Vancomycin (14)  ·  Loperamide (12)  ·  Azithromycin (11)  ·  ORALIT (10)  ·  Zinc Sulfate (10)  ·  Fecal Microbiota Transplantation (9)  ·  Octreotide (9)  ·  Sugars (9)  ·  maltodextrin (8)  ·  RIX4414 vaccine (7)  ·  Irinotecan (6)  ·  Sanitation (6)

Sponsors

London School of Hygiene and Tropical Medicine (16)  ·  International Centre for Diarrhoeal Disease Research, Bangladesh (14)  ·  Bausch Health Americas, Inc. (11)  ·  Johns Hopkins Bloomberg School of Public Health (10)  ·  Centers for Disease Control and Prevention (9)  ·  PATH (9)  ·  Mayo Clinic (8)  ·  Society for Applied Studies (8)  ·  International Vaccine Institute (7)  ·  Medical University of Warsaw (7)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (7)  ·  Aga Khan University (6)  ·  GlaxoSmithKline (6)  ·  Société des Produits Nestlé (SPN) (6)  ·  Stanford University (6)

Countries

United States (210)  ·  Bangladesh (43)  ·  Canada (37)  ·  India (35)  ·  China (31)  ·  United Kingdom (28)  ·  Kenya (25)  ·  Mexico (21)  ·  Poland (18)  ·  Germany (17)  ·  Italy (17)  ·  France (16)  ·  Pakistan (16)  ·  Zambia (13)  ·  Spain (12)

Top investigators

Nita Bhandari, PhD (5)  ·  Faming Zhang, PhD (4)  ·  Oliver Cumming, MSc (4)  ·  Stephen Freedman, MD (4)  ·  Halvor Sommerfelt, MD, PhD (3)  ·  Robin McKenzie, M.D. (3)  ·  Amy Pickering, PhD (2)  ·  Anna Lyra, PhD (2)  ·  Anthony Lembo, MD (2)

Results publications

PMID 42286373, PMID 36994923, PMID 41245385, PMID 36922331, PMID 20412178, PMID 21208106, PMID 22520120, PMID 22752857, PMID 22752865, PMID 23715579, PMID 23996605, PMID 24599770, PMID 24697851, PMID 24912386, PMID 28167156, PMID 30624600, PMID 32747931, PMID 10545590, PMID 10729239, PMID 11321031, PMID 11514838, PMID 11522739, PMID 11692292, PMID 12042580, PMID 12052800, PMID 12721240, PMID 12809830, PMID 12827001, PMID 12972590, PMID 15017618, PMID 15106189, PMID 15123074, PMID 15139502, PMID 15374659, PMID 15848292, PMID 15893282, PMID 15897530, PMID 15961682, PMID 16051399, PMID 16205711, PMID 16254536, PMID 16531144, PMID 16553931, PMID 16601430, PMID 16800167, PMID 16950955, PMID 17132678, PMID 17382603, PMID 17604300, PMID 18450870

NIH funding

2008 (3), 2009 (2), 2014 (2), 2019 (2), R01NR005337 (2), UL1RR024150 (2), 1DP5OD019893 (1), 2015 (1), 2025 (1), 5UM1AI148684-04 (1), DP5OD019893 (1), K01TW008401 (1), K01TW009208 (1), K23DK124567 (1), P01CA081403 (1)