59 completed, 19 unknown, 17 recruiting, 9 not yet recruiting. 50 Not applicable, 13 Phase 2, 8 Phase 1, 6 Phase 4, 5 Phase 3.
Follow Dysphonia: new trials by email Literature Review of Dysphonia trials Research Report on Dysphonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Personalized Voice Restoration Device for Patients With Laryngectomy Surface Electromyography - Dysphonia, Aphonia | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 100 | 2027-12-01 | 2026-06-16 |
| Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia - Cough, Vocal Cord Atrophy | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 200 | 2027-01-01 | 2026-06-16 |
| Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires - Presbylarynx, Aspiration | Not applicable | Not yet recruiting | University of California, San Francisco | 40 | 2026-11-01 | 2026-09-18 |
| EMG-Guided Versus Endoscopic-Catheter Botulinum Toxin Injection for Spasmodic Dysphonia Intervention A - Electromyography (EMG)-Guided BTX Injection, Intervention B - Endoscopic Catheter BTX Injection - Spasmodic Dysphonia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 17 | 2026-10-21 | 2026-10-26 |
| Extended-release Sodium Oxybate (Lumryz) in Spasmodic Dysphonia and Voice Tremor sodium oxybate - Spasmodic Dysphonia, Laryngeal Dystonia | Phase 1 | Not yet recruiting | Kristina Simonyan | 8 | 2026-10-01 | 2026-04-28 |
| Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 132 | 2026-09-01 | 2026-08-17 |
| Laryngeal Vibro-tactile Stimulation as a Non-invasive Symptomatic Treatment for Spasmodic Dysphonia vibro-tactile stimulation (VTS) - Adductor Spasmodic Dysphonia, Abductor Spastic Dysphonia | Phase 2 | Withdrawn | University of Minnesota | 2026-08-01 | 2025-05-16 | |
| Transcranial Magnetic Stimulation in Laryngeal Dystonia Active rTMS, Sham rTMS, Speech-Language Therapy - Laryngeal Dystonia, Spasmodic Dysphonia | Not applicable | Not yet recruiting | Universidade Federal de Pernambuco | 20 | 2026-06-01 | 2026-07-06 |
| PhoRTE® Therapy Efficacy: In-Person Versus Telehealth exuberant voice therapy - Atrophy of Vocal Cord, Presbyphonia | Not applicable | Not yet recruiting | University of Southern California | 30 | 2026-01-25 | 2026-01-13 |
| Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia Vibrotactile Stimulation (VTS) - Laryngeal Dystonia | Not applicable | Recruiting | University of Minnesota | 20 | 2026-01-14 | 2026-03-19 |
| Deconstructing Voice Therapy: Towards Enhanced Communication Outcomes Hierarchical method, Non Hierarchical method - Dysphonia, Primary Muscle Tension Dysphonia (MTD) | Not applicable | Recruiting | Emory University | 120 | 2025-09-03 | 2025-10-20 |
| Gender-affirming Voice Training With Visual Feedback Visual-acoustic biofeedback: experimental - Transgender Women, Voice Alteration | Not applicable | Terminated | University of Cincinnati | 6 | 2025-06-05 | 2025-07-24 |
| The Mechanism Versus PPI Trial Omeprazole 40 MG, Laryngeal Recalibration Therapy, GERD Lifestyle Recommendations - Laryngopharyngeal Reflux, Cough | Phase 4 | Recruiting | University of California, San Diego | 160 | 2025-06-04 | 2025-08-01 |
| Effects of Finger Kazoo Exercise With and Without Oropharyngeal Enlargement in the Operatic Singing Voice Condition A, Condition B - Voice Alteration | Not applicable | Completed | Aveiro University | 15 | 2025-05-30 | 2025-08-19 |
| Correlation Between Voice Pitch Changes and Tension of Suboccipital Muscles In Normal Subjects Voice Change, Suboccipital Muscles Tension | Active not recruiting | Cairo University | 119 | 2025-05-01 | 2025-06-06 | |
| tDCS for Laryngeal Dystonia Starstim system - Laryngeal Dystonia | Not applicable | Recruiting | Yale University | 10 | 2025-04-14 | 2026-02-09 |
| The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy Standard of care voice therapy, Expiratory muscle strength training (EMST) - Dysphonia, Unilateral Vocal Cord Paralysis | Not applicable | Withdrawn | University of Miami | 2025-04-01 | 2025-02-07 | |
| Capturing Key MG-symptoms Using Smartphone Recordings. Myasthenia Gravis, Fatigue | Recruiting | Leiden University Medical Center | 225 | 2025-03-18 | 2026-07-08 | |
| Dysphonia Pain Perception Following Botulinum Toxin Injections Ice Compress, No ice compress - Spasmodic Dysphonia | Not applicable | Completed | University of British Columbia | 116 | 2025-03-04 | 2026-02-18 |
| Voice Rest Versus Hypofunctional Whispering After Phonosurgery Absolute Voice Rest, Hypofunctional Whispering - Dysphonia, Vocal Cord Cyst | Not applicable | Completed | Celal Emre Çavlan | 16 | 2025-02-20 | 2026-07-15 |
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Deglutition Disorders (17) · Voice Disorders (17) · Dystonia (12) · Vocal Cord Paralysis (8) · Hoarseness (6) · Tremor (6) · Dystonic Disorders (5) · Communication Disorders (4) · Laryngeal Diseases (4) · Parkinson Disease (4) · Cough (3) · Dysarthria (3) · Pharyngitis (3) · Anxiety Disorders (2)
Neurologic Manifestations (117) · Otorhinolaryngologic Diseases (117) · Pathological Conditions, Signs and Symptoms (117) · Respiratory Tract Diseases (117) · Signs and Symptoms (117) · Nervous System Diseases (116) · Laryngeal Diseases (113) · Voice Disorders (100) · Digestive System Diseases (19) · Esophageal Diseases (19) · Gastrointestinal Diseases (19) · Pharyngeal Diseases (18) · Dyskinesias (15) · Central Nervous System Diseases (13) · Respiration Disorders (11)
Botulinum Toxins, Type A (4) · Sodium Oxybate (3) · Blood Specimen Collection (2) · Deep Brain Stimulation (2) · Electromyography (2) · Lansoprazole (2) · Saline Solution (2) · Transcranial Magnetic Stimulation (2) · Amifampridine (1) · Biofeedback, Psychology (1) · Botulinum Toxins (1) · Bupivacaine (1) · Dexamethasone (1) · Dextromethorphan (1) · Epinephrine (1)
National Institute of Neurological Disorders and Stroke (NINDS) (8) · University of Minnesota (6) · Kristina Simonyan (5) · Massachusetts Eye and Ear Infirmary (5) · NYU Langone Health (4) · University of British Columbia (3) · University of California, San Francisco (3) · University of Southern California (3) · Cairo University (2) · Emory University (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Marmara University (2) · Mayo Clinic (2) · Taipei Veterans General Hospital, Taiwan (2) · University of California, San Diego (2)
United States (65) · Turkey (Türkiye) (9) · United Kingdom (5) · Canada (4) · France (4) · Taiwan (4) · Egypt (3) · Italy (2) · Japan (2) · South Korea (2) · Austria (1) · Belgium (1) · Croatia (1) · Greece (1) · Hong Kong (1)
Kristina Simonyan, MD, PhD (9) · Juergen Konczak, PhD (2) · Yue Ma, MD (2) · Aaron Johnson (1) · Aaron Johnson, MD (1) · Aaron Rothbart, PhD (1) · Adam T Lloyd, SLP-D, MM, MA (1) · Alexandre Kreisler, MD (1) · Allen R Braun, M.D. (1) · Amanda Gillespie, PhD (1) · Amel M Yousef, PhD (1) · Andrew Vahabzadeh-Hagh, MD (1) · Aurora Ka Yue Tam (1)
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R01DC012545 (2), 2019 (1), K23DC016335 (1), K24DC018603 (1), R01DC011805 (1), R01DC016315 (1), R01DC022026 (1), R01DE030464 (1), R01DK139089 (1), R03DC012429 (1), R15DC021255 (1), R21DC021537 (1), U54NS065701 (1)