243 completed, 73 unknown, 51 recruiting, 27 terminated. 221 Not applicable, 60 Phase 2, 31 Phase 3, 30 Phase 1, 26 Phase 4.
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM) | Phase 2 | Not yet recruiting | HealthPartners Institute | 80 | 2027-01-01 | 2026-10-23 |
| The BRIGHT Study (Device Name: HALO System) The HALO System - Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2 | Not applicable | Not yet recruiting | Indigo Diabetes NV | 12 | 2026-12-01 | 2026-08-04 |
| Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 60 | 2026-12-01 | 2026-10-21 |
| Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise | Not applicable | Not yet recruiting | McGill University | 18 | 2026-11-01 | 2026-10-20 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes PAL-119, Placebo - Healthy Volunteers and Diabetes Participants | Phase 1 / Phase 2 | Not yet recruiting | Paulex Bio Inc. | 147 | 2026-11-01 | 2026-10-28 |
| LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes | Not applicable | Recruiting | German Institute of Human Nutrition | 300 | 2026-10-26 | 2026-10-28 |
| Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis | Not applicable | Recruiting | McGill University | 18 | 2026-10-23 | 2026-10-23 |
| Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit Metabolic Acidosis, Acid-Base Imbalance | Not yet recruiting | Assiut University | 140 | 2026-10-01 | 2026-09-03 | |
| Perfusion Index for Predicting Diabetic Ketoacidosis Severity in the Emergency Department Diabetic Ketoacidosis | Recruiting | Ankara Etlik City Hospital | 140 | 2026-09-15 | 2026-09-16 | |
| A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis | Phase 4 | Recruiting | Mayo Clinic | 250 | 2026-09-14 | 2026-09-21 |
| Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis Diabetic Ketoacidosis, Diabetes Mellitus | Not yet recruiting | Assiut University | 120 | 2026-09-10 | 2026-09-16 | |
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness Delayed nutrition, Standard nutrition, Fasting - Critical Illness, Fasting State | Not applicable | Not yet recruiting | Karolinska University Hospital | 200 | 2026-08-31 | 2026-09-01 |
| Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits Fibre Arm, Control Arm - Fasting, Dietary Fibre | Not applicable | Recruiting | Buchinger Wilhelmi Development & Holding GmbH | 75 | 2026-08-31 | 2026-09-30 |
| Ketones for Opioid Craving Treatment with Ketone Supplement, Treatment with Placebo - Opioid Use Disorder | Phase 2 | Recruiting | University of Maryland, Baltimore | 50 | 2026-07-16 | 2026-08-25 |
| Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis Oral sodium bicarbonate, Increased Dialysate Bicarbonate - End-stage Renal Disease (ESRD), Chronic Hemodialysis | Not applicable | Not yet recruiting | University of Sfax | 37 | 2026-07-01 | 2026-07-21 |
| Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis Ventilatory support via nasal high flow, Ventilatory support via NIV - Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis | Not applicable | Recruiting | University Hospital, Montpellier | 174 | 2026-06-16 | 2026-06-22 |
| Exogenous Ketone Supplementation in ICU Delirium Ketone monoester, Placebo - ICU Delirium, Critical Illness | Phase 2 | Recruiting | Vanderbilt University Medical Center | 40 | 2026-06-09 | 2026-08-24 |
| Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies Metabolic Diseases, Diabetes Mellitus (Type 2) | Not yet recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 118 | 2026-06-01 | 2026-05-08 |
Showing 20 of 449. Sign in to see all of them.
Ketosis (213) · Diabetic Ketoacidosis (73) · Acidosis, Lactic (47) · Diabetes Mellitus, Type 1 (31) · Diabetes Mellitus (26) · Diabetes Mellitus, Type 2 (22) · Renal Insufficiency, Chronic (21) · Acidosis, Respiratory (20) · Motor Activity (20) · Obesity (15) · Hypoxia (13) · Insulin Resistance (13) · Acute Kidney Injury (12) · Hyperglycemia (12)
Nutritional and Metabolic Diseases (448) · Acid-Base Imbalance (444) · Metabolic Diseases (440) · Pathological Conditions, Signs and Symptoms (148) · Endocrine System Diseases (115) · Pathologic Processes (89) · Diabetes Mellitus (86) · Glucose Metabolism Disorders (84) · Signs and Symptoms (79) · Diabetes Complications (72) · Ketosis (68) · Urogenital Diseases (64) · Female Urogenital Diseases and Pregnancy Complications (62) · Female Urogenital Diseases (58)
Sodium Bicarbonate (21) · formic acid 4-(3-oxobutyl)phenyl ester (16) · Diet, Ketogenic (14) · Sodium Chloride (12) · Ringer's Lactate (10) · Saline Solution (9) · Ketones (8) · Blood Specimen Collection (7) · Insulin (7) · Insulin Glargine (7) · dapagliflozin (7) · 3-Hydroxybutyric Acid (6) · Dichloroacetic Acid (6) · Metformin (6) · Continuous Glucose Monitoring (5)
Université de Sherbrooke (18) · University of Aarhus (17) · University of British Columbia (13) · Johns Hopkins University (8) · University of Colorado, Denver (8) · KU Leuven (7) · University of Florida (6) · Albert Einstein College of Medicine (5) · Assiut University (5) · Duke University (5) · McGill University (5) · Ohio State University (5) · Sohag University (5) · University of Pennsylvania (5) · Emory University (4)
United States (146) · Canada (56) · Denmark (34) · United Kingdom (27) · France (25) · Germany (21) · Italy (21) · Belgium (19) · Spain (11) · Australia (10) · Egypt (9) · Turkey (Türkiye) (9) · Switzerland (8) · Israel (7) · Netherlands (7)
Corinde Wiers, Ph.D. (4) · Eric H Kossoff, MD (4) · Stephen Cunnane, PhD (4) · Jonathan Jun, MD (3) · Karim Brohi, MD (3) · Antonio Paoli, MD (2) · Christophe De Block, MD, PhD (2) · Giacomo Grasselli, MD (2) · Guillermo Umpierrez, MD (2) · Jacob T Mey, PhD, RD (2) · Jeff Volek, PhD (2) · Jessica Kendrick, MD (2)
PMID 42458538, PMID 32071135, PMID 33074729, PMID 37889573, PMID 39804761, PMID 40043832, PMID 41315088, PMID 10064682, PMID 10102718, PMID 10189326, PMID 10218526, PMID 10371175, PMID 10546860, PMID 10563713, PMID 10634199, PMID 10789605, PMID 10971863, PMID 10988097, PMID 11046201, PMID 11071184, PMID 11188837, PMID 11216928, PMID 11262215, PMID 11366976, PMID 11399982, PMID 11604980, PMID 11719381, PMID 11722270, PMID 11737323, PMID 11740189, PMID 11807691, PMID 12008784, PMID 12126821, PMID 12134254, PMID 12172088, PMID 12186514, PMID 12243433, PMID 12534953, PMID 12553482, PMID 12558340, PMID 12640206, PMID 12741625, PMID 12819520, PMID 12853195, PMID 12859325, PMID 12891060, PMID 12957089, PMID 14518432, PMID 14581998, PMID 14627784
2018 (2), 2023 (2), K23HL161348 (2), R21AA031088 (2), 2008 (1), 2015 (1), 2016 (1), 2025 (1), K01HL169491 (1), K23HL128814 (1), P30AG028740 (1), P30AG059297 (1), R01AA031570 (1), R01CA125618 (1), R01DK072433 (1)