157 completed, 45 unknown, 37 recruiting, 30 terminated. 127 Not applicable, 18 Phase 2, 15 Phase 1, 12 Phase 4, 10 Early Phase 1.
Follow Barrett Esophagus: new trials by email Literature Review of Barrett Esophagus trials Research Report on Barrett Esophagus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial Cancer Screening, Computer-Assisted Intervention, Endoscopic Procedure - Barrett Esophagus, Esophageal Adenocarcinoma | Not applicable | Not yet recruiting | Mayo Clinic | 1010 | 2026-12-01 | 2026-06-24 |
| Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy | Not yet recruiting | Hospital de Mataró | 60 | 2026-12-01 | 2026-05-26 | |
| Lucid BE Biomarkers Study Tissue - Barrett's Esophagus, Barrett's Esophagus With Dysplasia | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2026-12-01 | 2026-10-21 | |
| Ursodeoxycholic Acid in Barrett's Endotherapy Barrett's Esophagus With Dysplasia | Not yet recruiting | Columbia University | 15 | 2026-11-01 | 2026-08-11 | |
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| Efficacy of Potassium-Competitive Acid Blockers in Barrett's Esophagus (PCAB BE Study) Potassium-Competitive Acid Blockers (PCABs) - Barrett Esophagus | Phase 4 | Not yet recruiting | University of North Carolina, Chapel Hill | 12 | 2026-08-31 | 2026-08-26 |
| Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus Biopsy Procedure, Biospecimen Collection, Endoscopic Procedure - Barrett Esophagus, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2026-06-23 | 2026-09-14 |
| A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer Risk profile disclosure - Barrett Esophagus, Barrett Esophagus Adenocarcinoma | Not applicable | Not yet recruiting | University Hospital, Antwerp | 266 | 2026-06-01 | 2026-03-06 |
| Digma System First in Human (FIH) Study Endoscopic Gastrointestinal Ablation Device (EGAD) - Barrett's Esophagus (BE) | Not applicable | Recruiting | Digma Medical Ltd. | 20 | 2026-05-25 | 2026-08-17 |
| Enhancing Screening Practices for BE Screening Reminder - Barrett's Esophagus | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 3000 | 2026-05-01 | 2026-05-05 |
| Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma Non-Interventional Study - Barrett Esophagus, Esophageal Adenocarcinoma | Enrolling by invitation | Mayo Clinic | 450 | 2025-11-17 | 2026-09-29 | |
| Impact of RFA on Esophageal Distensibility and Mucosal Impedance Radiofrequency ablation alone - Dysplastic Barrett's Esophagus, Radiofrequency Ablation | Recruiting | Mayo Clinic | 10 | 2025-08-19 | 2026-10-14 | |
| A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer Endoscopic brush cytology - Barrett's Esophagus, Esophageal Adenocarcinoma | Not applicable | Recruiting | University Hospital, Antwerp | 50 | 2025-08-13 | 2026-02-24 |
| BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY) Eosinophilic Esophagitis (EoE) | Completed | IRCCS San Raffaele | 100000 | 2025-07-23 | 2026-03-11 | |
| Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy. - Obese Patients, Tobacco Use | Not applicable | Recruiting | Louis Stokes VA Medical Center | 400 | 2025-04-11 | 2025-06-05 |
| Barrett's Esophagus in Patients with GERD Upper endoscopy - Barrett Esophagus | Not applicable | Not yet recruiting | Assiut University | 70 | 2025-04-01 | 2025-03-27 |
| Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms EsoCheck, EsoGuard - Barrett Esophagus, Gastroesophageal Reflux | Not applicable | Recruiting | Case Comprehensive Cancer Center | 800 | 2025-03-10 | 2026-09-15 |
| "Less-is-more in Barrett-surveillance" Care Evaluation of Barrett's Patients With Low-Risk in Whom Endoscopic Surveillance is Stopped. The BLISS Project. Discontinued endoscopic surveillance - Barrett Esophagus, Barrett Esophagus Adenocarcinoma | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 3156 | 2025-03-01 | 2025-10-03 | |
| Navicam for Detection of Barrett's Esophagus NaviCam Detachable String Capsule - Barrett's Esophagus | Not applicable | Recruiting | Mayo Clinic | 57 | 2025-02-20 | 2026-08-19 |
| Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples Barrett's Esophagus Test (LDT) - Barrett Esophagus | Recruiting | Cyted Health Inc | 700 | 2025-02-05 | 2026-07-29 |
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Gastroesophageal Reflux (69) · Adenocarcinoma Of Esophagus (56) · Esophageal Neoplasms (54) · Stomach Neoplasms (8) · Adenocarcinoma (6) · Esophagitis, Peptic (6) · Precancerous Conditions (6) · Eosinophilic Esophagitis (4) · Esophageal Diseases (4) · Esophagitis (4) · Heartburn (4) · Neoplasms (4) · Obesity (4) · Carcinoma in Situ (3)
Digestive System Diseases (303) · Gastrointestinal Diseases (302) · Esophageal Diseases (300) · Neoplasms (300) · Precancerous Conditions (298) · Esophageal Motility Disorders (69) · Deglutition Disorders (66) · Neoplasms by Site (63) · Digestive System Neoplasms (62) · Gastrointestinal Neoplasms (60) · Head and Neck Neoplasms (54) · Pathological Conditions, Signs and Symptoms (21) · Gastroenteritis (15) · Stomach Diseases (14) · Intestinal Diseases (13)
Endoscopy (15) · Endoscopy, Digestive System (13) · Biopsy (11) · Endoscopic Mucosal Resection (8) · Esomeprazole (7) · Radiofrequency Ablation (7) · Specimen Handling (7) · Gastroscopy (6) · Aspirin (4) · Omeprazole (4) · Proflavine (4) · Breath Tests (3) · Diagnostic Imaging (3) · Narrow Band Imaging (3) · 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (2)
Mayo Clinic (39) · Massachusetts General Hospital (17) · Midwest Biomedical Research (10) · University of North Carolina, Chapel Hill (9) · National Cancer Institute (NCI) (8) · Columbia University (7) · Johns Hopkins University (7) · University of Colorado, Denver (6) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (5) · CDx Diagnostics (5) · Case Comprehensive Cancer Center (5) · Lucid Diagnostics, Inc. (5) · Pentax Medical (5) · University Medical Center Groningen (5) · University of Cambridge (5)
United States (205) · Netherlands (27) · United Kingdom (23) · France (13) · Germany (13) · Belgium (9) · Sweden (6) · Australia (5) · Canada (5) · Italy (5) · Taiwan (4) · Austria (3) · Ireland (3) · Czechia (2) · Denmark (2)
Prateek Sharma, MD (13) · Nicholas Shaheen, MD, MPH (8) · Guillermo Tearney, MD, PhD (6) · Sachin Wani, MD (6) · Kenneth K Wang, MD (5) · Julian Abrams, MD (4) · Prasad G Iyer, MD (4) · Amitabh Chak, MD (3) · Cadman Leggett, MD (3) · Guillermo Tearney, MD PhD (3) · Jacques Bergman, MD (3) · Kenneth Wang, MD (3) · Norman Nishioka, MD (3) · Prasad G. Iyer, MD (3) · W.B. Nagengast, MD, PhD, PharmD (3)
PMID 22315471, PMID 24165758, PMID 26253018, PMID 33549871, PMID 38513982, PMID 14745410, PMID 16344051, PMID 17057569, PMID 17258973, PMID 18045592, PMID 18360296, PMID 18561930, PMID 19268726, PMID 19474425, PMID 19559419, PMID 19960205, PMID 20485617, PMID 20598302, PMID 20626453, PMID 20857372, PMID 21059667, PMID 21309920, PMID 21407181, PMID 21531411, PMID 21679712, PMID 21741642, PMID 21997553, PMID 22134936, PMID 22178570, PMID 22409435, PMID 22415199, PMID 22489016, PMID 22749368, PMID 22796132, PMID 22965650, PMID 23113846, PMID 23534776, PMID 23953402, PMID 24462171, PMID 24556051, PMID 24604584, PMID 24714327, PMID 24767575, PMID 25218668, PMID 25360316, PMID 25488897, PMID 25499989, PMID 26104794, PMID 26260107, PMID 26426999
R01CA184102 (4), R01CA103769 (3), R01CA241164 (3), P30CA046592 (2), R01CA210544 (2), UG1CA242632 (2), 2004 (1), K23DK068149 (1), K24DK100548 (1), N01CN00034 (1), N01CN35000 (1), N01CN35158 (1), N01CN35159 (1), P30CA013696 (1), P30CA014520 (1)