70 completed, 23 recruiting, 23 unknown, 10 terminated. 35 Not applicable, 33 Phase 2, 14 Phase 3, 12 Phase 1, 7 Phase 4.
Follow Chronic Cough: new trials by email Literature Review of Chronic Cough trials Research Report on Chronic Cough
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic COUGH Management in Interstitial Lung DisEase Non-pharmacological cough control therapy, Healthy lifestyle - Interstitial Lung Disease, Chronic Cough | Not applicable | Not yet recruiting | Aveiro University | 60 | 2027-12-20 | 2025-01-20 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection - Postoperative Cough, Cough Hypersensitivity Syndrome | Not applicable | Not yet recruiting | Tongji Hospital | 248 | 2026-09-01 | 2026-05-07 |
| Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough BCS+inactive, BCS+active - Chronic Cough (CC), Refractory Chronic Cough | Phase 2 | Recruiting | University of Montana | 135 | 2026-08-13 | 2026-08-18 |
| Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough Acceptance and Commitment Therapy (ACT) - Chronic Cough | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-08-01 | 2026-05-06 |
| A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough SC0032, Placebo - Refractory Chronic Cough and Unexplained Chronic Cough | Phase 2 | Recruiting | Sensory Cloud, Inc. | 60 | 2026-07-13 | 2026-10-14 |
| A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation Prototypes Camlipixant - Cough | Phase 1 | Withdrawn | GlaxoSmithKline | 2026-07-02 | 2026-08-31 | |
| The Effect of Nalbuphine Extended-Release (NAL ER) on Cough in Participants With Refractory Chronic Cough (RCC) NAL ER, Placebo - Refractory Chronic Cough | Phase 2 | Recruiting | Trevi Therapeutics | 100 | 2026-06-22 | 2026-10-13 |
| A Phase 2 Study of HW091077 in Participants With Refractory Chronic Cough Or Unexplained Chronic Cough (RCC/UCC). HW091077, Matching placebo to HW091077 - Refractory Chronic Cough | Phase 2 | Not yet recruiting | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. | 180 | 2026-05-01 | 2026-03-19 |
| Efficacy of Behavioral Therapy for Chronic Refractory Cough Behavioral Therapy - Chronic Cough | Not applicable | Recruiting | Assiut University | 30 | 2026-03-10 | 2026-04-23 |
| Biomarkers and Respiratory Omics as New CHildren Opportunities - Study of Clinical Outcomes and Predictivity Evaluation fiberoptic bronchoscopy, blood sample collection, Respiratory functional tests - Asthma in Children, Protracted Bacterial Bronchitis | Recruiting | Medical University of Warsaw | 160 | 2026-03-06 | 2026-07-30 | |
| Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance High resolution oesophageal manometry with impedance, 24-hour pH metry - Extraesophageal Reflux, Laryngopharyngeal Reflux | Not applicable | Not yet recruiting | University Hospital Ostrava | 160 | 2026-01-01 | 2026-01-23 |
| Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in Children No intervention (observational study) - Chronic Cough (CC) | Not yet recruiting | Shanghai Children's Medical Center | 400 | 2026-01-01 | 2025-12-29 | |
| Finnish Children´s Protracted Cough Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension, Placebo inhalation - Chronic Cough | Phase 3 | Recruiting | Tampere University Hospital | 100 | 2025-12-22 | 2026-05-13 |
| Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough Observational - Asthma, Chronic Obstructive Pulmonary Disease (COPD) | Recruiting | McMaster University | 240 | 2025-12-11 | 2026-09-24 | |
| A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension BLU-5937, Placebo - Refractory Chronic Cough | Phase 3 | Recruiting | GlaxoSmithKline | 75 | 2025-11-21 | 2026-06-16 |
| A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery. Patients were randomly grouped - Chronic Cough, Video-assisted Thoracoscopic Surgery (VATS) | Not applicable | Not yet recruiting | Fujian Medical University Union Hospital | 228 | 2025-10-01 | 2025-09-24 |
| The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges Adenosine 5'-triphosphate - Chronic Cough (CC), Asthma | Phase 1 | Recruiting | McMaster University | 33 | 2025-08-05 | 2025-08-29 |
| Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILD Sputum-guided management, Standard of Care - ILD | Not applicable | Recruiting | McMaster University | 120 | 2025-05-22 | 2026-10-07 |
| Validation of a Questionnaire to Measure Cough Severity Questionnaire - Cough | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 100 | 2025-05-01 | 2025-09-15 |
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Cough (51) · Gastroesophageal Reflux (10) · Asthma (9) · Pulmonary Disease, Chronic Obstructive (6) · cough hypersensitivity syndrome (6) · Respiratory Tract Diseases (5) · Respiration Disorders (4) · Signs and Symptoms, Respiratory (4) · Bronchiectasis (3) · COVID-19 (3) · Cough-Variant Asthma (3) · Pulmonary Fibrosis (3) · upper airway cough syndrome (3) · Fibrosis (2)
Pathological Conditions, Signs and Symptoms (138) · Signs and Symptoms (136) · Respiration Disorders (134) · Signs and Symptoms, Respiratory (134) · Respiratory Tract Diseases (133) · Cough (87) · Lung Diseases (21) · Bronchial Diseases (16) · Lung Diseases, Obstructive (15) · Pathologic Processes (13) · Digestive System Diseases (12) · Esophageal Diseases (12) · Esophageal Motility Disorders (12) · Gastrointestinal Diseases (12) · Deglutition Disorders (11)
Gefapixant (14) · BLU-5937 (5) · Sodium Chloride (4) · Bronchoscopy (3) · Lidocaine (3) · Surveys and Questionnaires (3) · Amitriptyline (2) · Azithromycin (2) · BID protein, human (2) · Behavior Therapy (2) · Blood Specimen Collection (2) · Data Collection (2) · Duloxetine Hydrochloride (2) · Nalbuphine (2) · Pregabalin (2)
McMaster University (7) · Merck Sharp & Dohme LLC (7) · Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (6) · GlaxoSmithKline (5) · Mayo Clinic (5) · University of Montana (5) · Bayer (4) · Bellus Health Inc. - a GSK company (4) · Medical University of Warsaw (4) · Manchester University NHS Foundation Trust (3) · The First Affiliated Hospital of Guangzhou Medical University (3) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Guangdong Hengrui Pharmaceutical Co., Ltd (2) · Guangzhou Institute of Respiratory Disease (2) · Guangzhou Medical University (2)
United States (42) · United Kingdom (33) · China (23) · Canada (20) · Poland (12) · Czechia (9) · Spain (8) · France (7) · Germany (7) · Italy (7) · Japan (7) · Netherlands (6) · Australia (5) · Hungary (5) · Israel (5)
Imran Satia, MD, PhD (2) · Kian Fan Chung, MD (2) · Laurie J Slovarp, PhD (2) · Vivek N Iyer, MD (2) · Ahmet Tutuncu, MD, PhD (1) · Alyn H Morice, MD, Mphil (1) · Amanda Gillespie, PhD (1) · Andrew J Lipton, M.D. (1) · Anna M Nathan (1) · Annamaria Staiano (1) · Anthony R Harnden (1)
PMID 26426314, PMID 35248186, PMID 35569802, PMID 11511368, PMID 12403874, PMID 1285737, PMID 12927665, PMID 15672845, PMID 17053496, PMID 18006882, PMID 18828160, PMID 20585638, PMID 20864608, PMID 21330456, PMID 21458735, PMID 21830316, PMID 21885727, PMID 22018993, PMID 22230731, PMID 22349069, PMID 22819521, PMID 23146374, PMID 23630581, PMID 23646159, PMID 24229360, PMID 24461900, PMID 24482322, PMID 24521788, PMID 25079477, PMID 25307313, PMID 25467586, PMID 25516281, PMID 25638182, PMID 26285610, PMID 26492842, PMID 26741046, PMID 26842959, PMID 27214047, PMID 28232410, PMID 28265556, PMID 28502417, PMID 28839984, PMID 28923239, PMID 29016626, PMID 29080708, PMID 29225146, PMID 30215382, PMID 30722097, PMID 31023759, PMID 31023843
2017 (5), 2015 (4), 2019 (4), 2018 (1), 2023 (1), 2025 (1), K23HL169934 (1), R34HL132369 (1), R34HL174877 (1)