2371 completed, 986 unknown, 747 recruiting, 359 terminated. 1655 Not applicable, 1108 Phase 2, 604 Phase 1, 420 Phase 3, 238 Phase 4.
Follow Esophageal Diseases: new trials by email Literature Review of Esophageal Diseases trials Research Report on Esophageal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Neoadjuvant Therapy for Esophageal Cancer Neoadjuvant concurrent chemoradiotherapy - Esophageal Carcinoma, Neoadjuvant Therapy | Not applicable | Enrolling by invitation | Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center | 43 | 2028-03-01 | 2025-05-25 |
| AI-Enabled Mobile App for Safe Eating in Older Adults With Dysphagia AI-Enabled Mobile Application plus Standard Care, Standard Dysphagia Education - Deglutition Disorders, Dysphagia | Not applicable | Not yet recruiting | KAM Chi Shan Anna | 332 | 2028-01-01 | 2026-09-23 |
| Oral Fosamprenavir for GERD Fosamprenavir Calcium 700 MG Oral Tablet, Placebo - Refractory Gastroesophageal Reflux Disease, Gastroesophageal Reflux Disease | Phase 2 | Not yet recruiting | Medical College of Wisconsin | 60 | 2027-10-01 | 2026-09-10 |
| Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment - Dysphagia, Critical Illness | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 120 | 2027-07-01 | 2026-10-14 |
| Parent Implemented Oral Nutrition, Eating, and Esophageal Reflexes Reintegration Protocol: RCT PIONEER Protocol - Deglutition Disorders in Infants, Chronic Tube Feeding in Hospitalized Infants | Not applicable | Not yet recruiting | Nationwide Children's Hospital | 130 | 2027-07-01 | 2026-08-28 |
| Swallowing Impairments in ICU Survivors and Community-Dwelling Adults Dysphagia, Healthy Aging | Withdrawn | Vanderbilt University Medical Center | 2027-04-01 | 2026-06-02 | ||
| Maximizing Quality of Life After Cancer Through Rehabilitation TIMELY REHAB - Head and Neck Cancer, Hearing Loss | Not applicable | Not yet recruiting | VA Office of Research and Development | 74 | 2027-03-01 | 2026-06-03 |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
| Interest of Telemedicine in Primary Care in an Multidisability Population Institutionalized Experimental procedure: swallowing assessment by telemedicine, Standard procedure: day hospitalization - Deglutition Disorders in Disabled Persons | Not applicable | Not yet recruiting | University Hospital, Toulouse | 62 | 2027-01-01 | 2026-08-28 |
| Endoscopic Band Ligation for Treating Reflux Disease Band Ligation - GERD | Not applicable | Not yet recruiting | El Katib Hospital | 10 | 2027-01-01 | 2026-09-10 |
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD Effortful swallow - Dysphagia, Parkinson Disease (PD) | Not applicable | Not yet recruiting | University of Alberta | 74 | 2027-01-01 | 2026-08-19 |
| Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia - Cough, Vocal Cord Atrophy | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 200 | 2027-01-01 | 2026-06-16 |
| Deep Brain Stimulation + Therapy for Stroke Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol - Stroke, Dysarthria | Not applicable | Not yet recruiting | Pirondini, Elvira, PhD | 15 | 2027-01-01 | 2026-09-30 |
| PhII Study of Toripalimab Followed by Definitive CRT & Adjuvant Toripalimab in Locally Advanced ESCC Toripalimab, Carboplatin + Paclitaxel - Esophageal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Vanderbilt-Ingram Cancer Center | 20 | 2026-12-31 | 2026-09-23 |
| Disposable Endoscope Platform in Third Space Endoscopic Procedures (Esophageal or Gastric) Per-Oral Endoscopic Myotomy - Achalasia, Gastroparesis | Withdrawn | Baylor College of Medicine | 2026-12-30 | 2026-10-01 | ||
| Effects of Different-Frequency Electroacupuncture on Suprahyoid Muscles in Post-Stroke Dysphagia: Efficacy and Neural Networks Low Frequency EA, Medium Frequency EA, High Frequency EA - Stroke Sequelae, Deglutition Disorders | Not applicable | Not yet recruiting | Kaili Chen | 102 | 2026-12-21 | 2026-09-24 |
| Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial Cancer Screening, Computer-Assisted Intervention, Endoscopic Procedure - Barrett Esophagus, Esophageal Adenocarcinoma | Not applicable | Not yet recruiting | Mayo Clinic | 1010 | 2026-12-01 | 2026-06-24 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy | Not yet recruiting | Hospital de Mataró | 60 | 2026-12-01 | 2026-05-26 |
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Esophageal Neoplasms (1840) · Gastroesophageal Reflux (1171) · Deglutition Disorders (832) · Esophageal Squamous Cell Carcinoma (622) · Stomach Neoplasms (586) · Barrett Esophagus (304) · Adenocarcinoma Of Esophagus (252) · Pancreatic Neoplasms (248) · Eosinophilic Esophagitis (234) · Carcinoma, Non-Small-Cell Lung (229) · Lung Neoplasms (207) · Colorectal Neoplasms (202) · Head and Neck Neoplasms (185) · Breast Neoplasms (178) · Neoplasms (161)
Digestive System Diseases (5161) · Gastrointestinal Diseases (5141) · Neoplasms (2514) · Neoplasms by Site (2405) · Digestive System Neoplasms (2327) · Gastrointestinal Neoplasms (2274) · Head and Neck Neoplasms (2192) · Esophageal Motility Disorders (1365) · Deglutition Disorders (1357) · Neoplasms by Histologic Type (998) · Pathological Conditions, Signs and Symptoms (938) · Neoplasms, Glandular and Epithelial (936) · Otorhinolaryngologic Diseases (922) · Carcinoma (882)
Cisplatin (241) · Paclitaxel (184) · Radiotherapy (176) · Fluorouracil (167) · Esomeprazole (119) · Carboplatin (111) · Oxaliplatin (100) · pembrolizumab (90) · Docetaxel (86) · Irinotecan (78) · Drug Therapy (73) · Capecitabine (71) · Lansoprazole (64) · Leucovorin (64) · Radiation (61)
Mayo Clinic (111) · AstraZeneca (110) · National Taiwan University Hospital (61) · Fudan University (54) · National Cancer Institute (NCI) (53) · Sun Yat-sen University (47) · Takeda (45) · Memorial Sloan Kettering Cancer Center (42) · Shanghai Zhongshan Hospital (41) · M.D. Anderson Cancer Center (35) · Massachusetts General Hospital (34) · Tianjin Medical University Cancer Institute and Hospital (33) · Assiut University (29) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (29) · Chinese Academy of Medical Sciences (27)
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Nieto Luis, Master (22) · Prateek Sharma, MD (17) · Nicholas Shaheen, MD, MPH (12) · David H. Ilson, MD, PhD (11) · Ronnie Fass, MD (10) · Nieto Luis (9) · Paula Fernstrom (9) · Aminah Jatoi, MD (8) · David S Schrump, M.D. (8)
PMID 19735233, PMID 33538338, PMID 20354937, PMID 21129076, PMID 22646630, PMID 26808342, PMID 36990609, PMID 20195905, PMID 26254683, PMID 30089078, PMID 10922086, PMID 1451966, PMID 17270511, PMID 18309943, PMID 21441148, PMID 21684205, PMID 22068665, PMID 22146488, PMID 22609984, PMID 23451835, PMID 24118079, PMID 26313683, PMID 33373868, PMID 34454674, PMID 35623069, PMID 41309527, PMID 42031097, PMID 7721004, PMID 10235156, PMID 10734019, PMID 10744834, PMID 11176287, PMID 11208820, PMID 11870157, PMID 12003381, PMID 14687818, PMID 15044898, PMID 15100955, PMID 15544027, PMID 16137276, PMID 16437729, PMID 17141231, PMID 17643723, PMID 17997404, PMID 18167180, PMID 18590344, PMID 18590345, PMID 18760173, PMID 19183157, PMID 19465425
2023 (26), 2019 (17), 2015 (10), 2018 (10), 2014 (9), 2017 (9), 2008 (8), 2025 (7), 2016 (6), P30CA043703 (6), P30CA008748 (5), P30CA068485 (5), U10CA032102 (5), 2009 (4), P30CA015083 (4)