109 completed, 21 unknown, 6 terminated, 4 recruiting. 34 Not applicable, 30 Phase 3, 30 Phase 4, 19 Phase 2, 14 Phase 1.
Follow Heartburn: new trials by email Literature Review of Heartburn trials Research Report on Heartburn
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia | Not applicable | Not yet recruiting | McMaster University | 96 | 2026-10-01 | 2026-08-10 |
| New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial) Esophageal barrier medical device, Placebo oral formulation - GERD (Gastroesophageal Reflux Disease), NERD | Not applicable | Recruiting | Cellmedis | 50 | 2026-05-28 | 2026-07-10 |
| Potassium Competitive Acid Blocker (PCAB) Test-Guided vs Physiologic Test-Guided Treatment in Patients With Typical Reflux Symptoms PCAB-test guided - GERD, Acid Reflux, Treatment | Not applicable | Enrolling by invitation | Mahidol University | 120 | 2026-03-18 | 2026-07-16 |
| A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes PepZinGI, Placebo - Heartburn | Not applicable | Completed | NutriScience Innovations, LLC | 50 | 2026-01-15 | 2026-06-17 |
| Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI Therapy Hydrotalcite (Talcid, BAYX002833) - Gastroesophageal Reflux | Recruiting | Bayer | 167 | 2025-11-18 | 2026-07-07 | |
| A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring Vonoprazan - Erosive Esophagitis, Heartburn | Recruiting | Phathom Pharmaceuticals, Inc. | 728 | 2025-05-15 | 2026-09-18 | |
| Observationa Study is a Prospective and Multi-institutional Observational Study. Erosive Reflux Disease, Heartburn | Completed | Jeil Pharmaceutical Co., Ltd. | 5536 | 2024-11-01 | 2025-05-13 | |
| The Anti-gastroesophageal Reflux Effect of Anvitra Gastric Suspension on Outpatients With Gastroesophageal Reflux Disease Anvitra Gastric Suspension - GERD (Heartburn, Regurgitation, and Dyspepsia) Frequency, GERD (Heartburn, Regurgitation, and Dyspepsia) Severity | Not applicable | Completed | Haiphong University of Medicine and Pharmacy | 27 | 2024-08-06 | 2025-09-15 |
| A Pre-market, Two-stages Interventional Clinical Investigation to Evaluate the Safety and the Performance of Fibroin Syrup in Reducing the Gastroesophageal Reflux Disease (GERD) Symptomatology in Nonerosive Reflux Disease (NERD) Patients Syrup made by hyaluronic acid - GERD (Heartburn, Regurgitation, and Dyspepsia), Gastroesophageal Reflux (GERD) | Not applicable | Completed | Rose Pharma SA | 47 | 2024-07-24 | 2026-05-04 |
| A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily Vonoprazan - Erosive Esophagitis, Heartburn | Phase 1 | Completed | Phathom Pharmaceuticals, Inc. | 15 | 2024-05-07 | 2025-03-25 |
| Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers Antareit - Heartburn, Acid-dependent Diseases of the Gastrointestinal Tract | Not applicable | Unknown | Valenta Pharm JSC | 50 | 2024-04-25 | 2024-07-22 |
| A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants bi-layer calcium carbonate tablet (BAY1180654), Immediate release calcium carbonate tablet (BAY1180654) - Heartburn, Indigestion | Phase 1 | Completed | Bayer | 21 | 2024-03-06 | 2024-07-03 |
| Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional Dyspepsia Itopride Hydrochloride 150 mg extended release tablets, Itopride Hydrochloride 50 mg film coated tablets - Functional Dyspepsia | Phase 3 | Completed | Abbott | 564 | 2024-02-28 | 2026-04-03 |
| A Study of Breath Testing for Small Intestinal Bacterial Overgrowth Breath Testing - Gastroesophageal Reflux, Regurgitation | Not applicable | Recruiting | Mayo Clinic | 50 | 2023-11-17 | 2026-02-12 |
| Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo - Gut Health | Not applicable | Completed | Supplement Formulators, Inc. | 143 | 2023-10-31 | 2026-01-13 |
| The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Symptoms. LEFT smartwatch app - Gastroesophageal Reflux, Heartburn | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 18 | 2023-10-01 | 2025-05-31 |
| Smartphone App-assisted PPI App-based treatment support - Heartburn, Dyspepsia | Not applicable | Completed | University Hospital, Basel, Switzerland | 60 | 2023-09-05 | 2025-02-13 |
| Prevalence of Fuctional Heartburn in Patients With IBS . Heartburn | Unknown | Assiut University | 100 | 2023-07-01 | 2023-06-13 | |
| Primary carE PPi dEprescRibing Trial de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate - Heartburn, Dyspepsia | Phase 4 | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 724 | 2023-05-12 | 2025-01-31 |
| Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD MHS-1031, Placebo - Gastroesophageal Reflux | Phase 2 | Completed | Microbiome Health Sciences | 255 | 2023-03-03 | 2026-07-27 |
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Gastroesophageal Reflux (92) · Dyspepsia (19) · Esophagitis (9) · Abdominal Pain (7) · Nausea (6) · Non-Erosive Reflux Disease (5) · Barrett Esophagus (4) · Diarrhea (4) · Esophagitis, Peptic (4) · Laryngopharyngeal Reflux (4) · Constipation (3) · Parasomnias (3) · Sleep Initiation and Maintenance Disorders (3) · Sleep Wake Disorders (3)
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Esomeprazole (22) · Lansoprazole (17) · Dexlansoprazole (9) · Omeprazole (9) · Rabeprazole (9) · Pantoprazole (5) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (4) · Alginates (3) · Famotidine (3) · lesogaberan (3) · tegaserod (3) · Calcium Carbonate (2) · Magnesium Hydroxide (2) · Nortriptyline (2) · Restraint, Physical (2)
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PMID 19735233, PMID 25141241, PMID 27331882, PMID 29788903, PMID 31297231, PMID 15233698, PMID 15365964, PMID 16688361, PMID 18267026, PMID 18561877, PMID 18721738, PMID 19028251, PMID 19116333, PMID 19140233, PMID 19210493, PMID 19392864, PMID 19925497, PMID 20132153, PMID 20456300, PMID 21129076, PMID 21224838, PMID 21317257, PMID 21320138, PMID 21402616, PMID 21716130, PMID 22155561, PMID 22372795, PMID 22510027, PMID 22730470, PMID 22923162, PMID 23318482, PMID 23426452, PMID 23451835, PMID 23919738, PMID 24024757, PMID 24063425, PMID 24118079, PMID 24328943, PMID 24378321, PMID 24494987, PMID 24533896, PMID 24899360, PMID 25246239, PMID 25284142, PMID 25304129, PMID 25478944, PMID 25887111, PMID 25973022, PMID 26063325, PMID 26149189
2008 (2), R01DA003890 (1), R01DK063621 (1)