202 completed, 47 unknown, 44 recruiting, 28 terminated. 85 Not applicable, 72 Phase 2, 54 Phase 3, 26 Phase 1, 24 Phase 4.
Follow Esophagitis: new trials by email Literature Review of Esophagitis trials Research Report on Esophagitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy | Not yet recruiting | Hospital de Mataró | 60 | 2026-12-01 | 2026-05-26 | |
| The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States Esophageal string test - Dysphagia, Eosinophilic Esophagitis | Not applicable | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 70 | 2026-10-26 | 2026-10-21 |
| PPI Dosing Per CYP2C19 Genotype CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose - Gastroesophageal Reflux Disease With Esophagitis | Phase 4 | Not yet recruiting | University of Florida | 200 | 2026-10-01 | 2026-09-28 |
| A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis Upadacitinib 30mg Dose, Upadacitinib Matching Placebo - EoE, Eosinophilic Esophagitis | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 52 | 2026-09-30 | 2026-10-06 |
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| Sino-Russian Comparison of Outcomes After Proximal Gastrectomy With Double-Tract Reconstruction Proximal gastrectomy with double-tract reconstruction - Gastric Adenocarcinoma, Adenocarcinoma of the Esophagogastric Junction | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 250 | 2026-08-15 | 2026-09-02 | |
| Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions EndoFlip - Dysphagia, Esophageal Stricture | Not applicable | Recruiting | Johns Hopkins University | 25 | 2026-07-24 | 2026-08-24 |
| Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal Disorders Elimination Diet - Eosinophilic Gastrointestinal Disorders (EGID) | Recruiting | Cukurova University | 34 | 2026-07-01 | 2026-08-21 | |
| Using Red Light Therapy to Ease Skin Side Effects and Mouth Side Effects, in Children and Young People Aged 0 to 16 Years Old, Receiving Radiotherapy Photobiomodulation - Radio Dermatitis, Mucositis Oral | Not applicable | Not yet recruiting | The Christie NHS Foundation Trust | 248 | 2026-06-01 | 2026-03-19 |
| The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic Esophagitis Eosinophilic Esophagitis (EoE), Dysphagia, Esophageal | Enrolling by invitation | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 25 | 2026-05-01 | 2026-07-29 | |
| Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis Partial enteral nutrition (PEN) with dairy elimination, Dairy elimination alone - Eosinophilic Esophagitis (EoE) | Not applicable | Recruiting | Kate Farms Inc | 36 | 2026-03-18 | 2026-04-16 |
| PRospective Registry of Esophageal Motility No intervention - Esophageal Diseases, Achalasia | Recruiting | IRCCS San Raffaele | 10000 | 2026-03-09 | 2026-04-02 | |
| Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis. Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], budesonide oral suspension - Eosinophilic Esophagitis (EoE) | Early Phase 1 | Enrolling by invitation | Mayo Clinic | 60 | 2026-02-04 | 2026-05-04 |
| Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD Conventional POEM, Sling Fiber-Preserving POEM - Achalasia, Esophageal, GERD (Gastroesophageal Reflux Disease) | Not applicable | Not yet recruiting | University of California, Irvine | 120 | 2025-12-01 | 2025-10-22 |
| A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County) Sedated gastroscopy - Reflux Esophagitis | Recruiting | Jilin University | 60 | 2025-12-01 | 2026-08-10 | |
| Utility of Mucosal Impedance Device in Chronic Esophageal Disorders: MuVI Esophageal mucosal impedance testing - Gerd, Eosinophilic Esophagitis | Recruiting | Medical College of Wisconsin | 50 | 2025-11-20 | 2026-07-27 | |
| A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis dupilumab - Eosinophilic Esophagitis (EoE) | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 20 | 2025-11-10 | 2026-09-29 |
| A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks Vonoprazan, Placebo - Eosinophilic Esophagitis | Phase 2 | Active not recruiting | Phathom Pharmaceuticals, Inc. | 95 | 2025-10-30 | 2026-10-13 |
| Natural History of Eosinophilic Esophagitis in Adult and Pediatric Population Eosinophilic Esophagitis (EoE) | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 200 | 2025-09-01 | 2026-06-29 | |
| Surface EMG Testing on Swallowing in EoE Patients Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing - Eosinophilic Esophagitis (EoE) | Active not recruiting | Mayo Clinic | 30 | 2025-08-04 | 2026-07-17 |
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Eosinophilic Esophagitis (234) · Esophagitis, Peptic (81) · Gastroesophageal Reflux (73) · Deglutition Disorders (22) · Eosinophilic enteropathy (18) · Esophageal Diseases (17) · Barrett Esophagus (14) · Gastrointestinal Diseases (12) · Stomach Neoplasms (12) · Eosinophilia (11) · Heartburn (11) · Hypersensitivity (11) · Food Hypersensitivity (10) · Esophageal Neoplasms (9)
Digestive System Diseases (368) · Gastroenteritis (368) · Gastrointestinal Diseases (364) · Esophageal Diseases (359) · Hemic and Lymphatic Diseases (234) · Immune System Diseases (232) · Hypersensitivity, Immediate (230) · Hematologic Diseases (229) · Leukocyte Disorders (229) · Eosinophilia (223) · Hypersensitivity (223) · Intestinal Diseases (95) · Stomach Diseases (93) · Duodenal Diseases (87)
Fluticasone (17) · dupilumab (15) · Lansoprazole (14) · Esomeprazole (13) · Budesonide (12) · Omeprazole (11) · Rabeprazole (9) · Dexlansoprazole (8) · Endoscopy, Digestive System (8) · AK002 (6) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (5) · APT-1011 (5) · BID protein, human (4) · Endoscopy (4) · Pantoprazole (4)
Mayo Clinic (26) · AstraZeneca (15) · Children's Hospital Medical Center, Cincinnati (13) · Takeda (13) · University of North Carolina, Chapel Hill (9) · University of Colorado, Denver (8) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Regeneron Pharmaceuticals (7) · Allakos Inc. (6) · Ann & Robert H Lurie Children's Hospital of Chicago (6) · Dr. Falk Pharma GmbH (5) · IRCCS San Raffaele (5) · Pfizer (5) · Shire (5) · Celgene (4)
United States (212) · China (26) · Canada (24) · Italy (23) · Japan (21) · United Kingdom (21) · Germany (20) · Switzerland (17) · Australia (16) · Spain (14) · Belgium (13) · Netherlands (11) · Poland (11) · France (10) · Israel (9)
Evan S Dellon, MD, MPH (8) · Craig Paterson, MD (5) · David Katzka, MD (5) · Joshua B Wechsler, MD (5) · Marc E Rothenberg, MD, PhD (5) · Karthik Ravi, MD (4) · Marc E. Rothenberg, M.D., Ph.D. (4) · Calies Menard-Katcher, MD (3) · Evan Dellon, MD, MPH (3) · Pingsheng Hu, Ph.D (3)
PMID 19735233, PMID 20195905, PMID 21129076, PMID 42031097, PMID 19183157, PMID 19681809, PMID 22607579, PMID 23451835, PMID 24118079, PMID 28809387, PMID 34182150, PMID 36574003, PMID 37718471, PMID 39735351, PMID 41711386, PMID 41749054, PMID 10049409, PMID 10332535, PMID 15180722, PMID 16268977, PMID 16329022, PMID 16553582, PMID 16997628, PMID 17305763, PMID 17488253, PMID 17919504, PMID 19210298, PMID 19828470, PMID 19935783, PMID 19960205, PMID 20010088, PMID 20379093, PMID 20457157, PMID 20542323, PMID 20920599, PMID 20925534, PMID 21356058, PMID 22111863, PMID 22206777, PMID 22464259, PMID 22510027, PMID 22561055, PMID 22895393, PMID 23333143, PMID 23426452, PMID 23567357, PMID 24177377, PMID 24314292, PMID 24768678, PMID 24907494
U54AI117804 (4), 2014 (3), 2018 (2), 2019 (2), UL1TR001082 (2), 2009 (1), 2016 (1), 2023 (1), K23DK090073 (1), K23DK129784 (1), P30CA069533 (1), P30CA072720 (1), R01CA103769 (1), R01DK063621 (1), R01DK068158 (1)