307 completed, 31 unknown, 23 terminated, 19 recruiting. 200 Phase 1, 83 Phase 4, 52 Phase 3, 37 Phase 2, 34 Not applicable.
Follow Omeprazole: new trials by email Literature Review of Omeprazole trials Research Report on Omeprazole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only - Hypovitaminosis b 12 | Phase 3 | Not yet recruiting | Tanta University | 23 | 2026-12-30 | 2025-05-13 |
| A Study to Investigate the Effect of Omeprazole and Cyclosporine on Velzatinib in Healthy Participants Velzatinib, Cyclosporine, Omeprazole - Healthy Participants, Gastrointestinal Neoplasms | Phase 1 | Not yet recruiting | GlaxoSmithKline | 36 | 2026-10-16 | 2026-10-07 |
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| Effect of Omeprazole on Gut Microbiota in Adults With Obesity and GERD Omeprazole, Standard Non-pharmacological Recommendations for GERD - Obesity & Overweight, Gastroesophageal Reflux Disease | Phase 4 | Not yet recruiting | Federal State Budgetary Scientific Institution | 26 | 2026-09-25 | 2026-10-01 |
| A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults Itraconazole, Rifampicin, Omeprazole - Healthy Subjects | Phase 1 | Not yet recruiting | InventisBio Co., Ltd | 60 | 2026-09-16 | 2026-10-15 |
| Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo - Helicobacter Pylori Infection, Dyspepsia | Not applicable | Not yet recruiting | Gala Servicios Clinicos S.L. | 140 | 2026-08-31 | 2026-07-27 |
| An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Afimkibart, Caffeine, Warfarin - Active Ulcerative Colitis | Phase 1 | Recruiting | Hoffmann-La Roche | 25 | 2026-06-29 | 2026-10-16 |
| Study of Teprenone in the Treatment of Glucocorticoid-Induced Drug-Related Gastrointestinal Injury Omeprazole, Teprenone - Gastrointestinal and Digestive Disorder | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2026-06-01 | 2026-06-17 |
| A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer GDC-0587, Giredestrant, Omeprazole - Breast Cancer | Phase 1 | Terminated | Genentech, Inc. | 3 | 2026-01-13 | 2026-08-21 |
| Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants Repotrectinib, Metformin, Digoxin - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2025-12-31 | 2026-03-27 |
| Comparison of Two Treatment Regimens of Helicobacter Pylori Infection Clarithromycin, Levofloxacin - Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 156 | 2025-12-01 | 2025-06-15 |
| Treatment of Gastroesophageal Reflux Disease in Infants Protein pump inhibitor., Mother or infant diet, Placebo - Gastroesophageal Reflux, Infant, Newborn, Diseases | Phase 4 | Recruiting | Odense University Hospital | 96 | 2025-10-27 | 2025-11-20 |
| Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants Vorasidenib, Bupropion, Flurbiprofen - Healthy Adult Participants | Phase 1 | Completed | Institut de Recherches Internationales Servier (I.R.I.S.) | 28 | 2025-10-07 | 2026-02-17 |
| A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About BIIB141's Safety in Healthy Adults Aged 18 to 55 Omaveloxolone, Omeprazole - Healthy Volunteer | Phase 1 | Completed | Biogen | 22 | 2025-09-02 | 2025-10-23 |
| Effects of Omeprazole Ingestion on Postprandial Amino Acid Concentrations in Response to a Mixed Meal Omeprazole 20 mg, Placebo - Digestive Health, Gastrointestinal Health | Not applicable | Completed | McGill University | 4 | 2025-09-01 | 2026-07-15 |
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ABS-1230 Given Orally Compared With Placebo in Healthy Participants Aged 18 to 55 Years ABS-1230, Placebo, Omeprazole - KCNT1-Related Epilepsy | Phase 1 | Recruiting | Actio Biosciences, Inc. | 92 | 2025-08-28 | 2026-08-07 |
| A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma. Omeprazole, Dextromethorphan - Hodgkin Lymphoma, Non Hodgkin Lymphoma | Phase 1 | Recruiting | Murdoch Childrens Research Institute | 10 | 2025-07-22 | 2026-08-27 |
| Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg - H Pylori | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 128 | 2025-07-01 | 2025-06-27 |
| Comparing Effectiveness of Steroids and Methotrexate in Treatment of Chronic Inflammatory Breast Disease Prednisolone, Methotrexate, Folic Acid 5 MG - Idiopathic Granulomatous Mastitis | Phase 4 | Not yet recruiting | National University Hospital, Singapore | 40 | 2025-07-01 | 2025-04-24 |
| Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone Atorvastatin 40mg Tablet, Omeprazole 20mg Capsule - Metabolite | Phase 4 | Recruiting | National University Hospital, Singapore | 78 | 2025-06-12 | 2025-07-02 |
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Gastroesophageal Reflux (39) · Dyspepsia (11) · Peptic Ulcer (10) · Heartburn (9) · Neoplasms (9) · Gastrointestinal Hemorrhage (7) · Peptic Ulcer Hemorrhage (7) · Arthritis, Rheumatoid (6) · Breast Neoplasms (6) · Laryngopharyngeal Reflux (6) · Stomach Ulcer (6) · Coronary Artery Disease (5) · Diabetes Mellitus, Type 2 (5) · Esophagitis, Peptic (5) · Non-Erosive Reflux Disease (5)
AstraZeneca (15) · Boehringer Ingelheim (13) · Bristol-Myers Squibb (10) · Eli Lilly and Company (8) · GlaxoSmithKline (8) · Bayer (7) · Pfizer (7) · Janssen Research & Development, LLC (6) · Damascus Hospital (5) · Dr. Reddy's Laboratories Limited (5) · Sanofi (5) · Amgen (4) · Hoffmann-La Roche (4) · Livzon Pharmaceutical Group Inc. (4) · Mayo Clinic (4)
United States (163) · United Kingdom (26) · China (25) · Germany (23) · Canada (16) · Poland (13) · Belgium (12) · South Korea (12) · Netherlands (11) · Brazil (10) · France (10) · Israel (10) · Taiwan (10) · Spain (9) · Switzerland (9)
Marouf M Alhalabi, MD (3) · David Mathews, MD (2) · Maotsugu Oyama, MD, PhD (2)
PMID 20844485, PMID 39604046, PMID 34433773, PMID 35510785, PMID 10049409, PMID 11895791, PMID 12161727, PMID 12526935, PMID 16174856, PMID 16329022, PMID 16481828, PMID 16611267, PMID 16948806, PMID 17442905, PMID 17589721, PMID 17919504, PMID 18407271, PMID 19036078, PMID 19086953, PMID 19298337, PMID 20458079, PMID 20539208, PMID 20578215, PMID 20638563, PMID 20679904, PMID 20858862, PMID 20920599, PMID 20925534, PMID 21284052, PMID 21305536, PMID 21345487, PMID 21347742, PMID 21521834, PMID 21839884, PMID 21908799, PMID 22057678, PMID 22070512, PMID 22109700, PMID 22123802, PMID 22372795, PMID 22464259, PMID 23333143, PMID 23351820, PMID 23429642, PMID 23567357, PMID 23574119, PMID 23630016, PMID 23750331, PMID 23856153, PMID 23917460
2014 (4), 2015 (4), 2023 (4), 2018 (3), 2009 (2), 2017 (2), R01AT007987 (2), 1UG1CA242632-01A1 (1), 2016 (1), 2019 (1), 2025 (1), P01GM032165 (1), P30CA012197 (1), P30CA014089 (1), P30CA014520 (1)