126 completed, 37 unknown, 23 recruiting, 14 active not recruiting. 151 Not applicable, 19 Phase 2, 12 Phase 1, 10 Phase 3, 10 Phase 4.
Follow Osteo Arthritis Knee: new trials by email Literature Review of Osteo Arthritis Knee trials Research Report on Osteo Arthritis Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals Electrodermal Activity signal - Osteo Arthritis Knee | Not applicable | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 15 | 2026-08-01 | 2026-03-06 |
| The Role of Rumination and Worry in Pain and Functional Limitation in Knee Osteoarthritis Osteo Arthritis Knee, Worries; Pain or Disability | Completed | Fatih Sultan Mehmet Training and Research Hospital | 103 | 2026-03-01 | 2026-09-01 | |
| Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis Arthrosamid® 2.5% iPAAG injectable implant, Steroid Drug - Osteo Arthritis Knee, Osteoarthritis | Phase 4 | Recruiting | Cappagh National Orthopaedic Hospital | 200 | 2026-01-29 | 2026-04-28 |
| Multimodal Treatment of Knee Osteoarthritis: Therapeutic Exercise and Noninvasive Neuromodulation (NESA) Versus Therapeutic Exercise and Transcutaneous Electrical Nerve Stimulation (TENS) in People Over 60 Years of Age. Therapeutic exercise and NESA VS. Therapeutic exercise and TENS - Osteo Arthritis Knee | Not applicable | Completed | University of Jaén | 110 | 2026-01-07 | 2026-07-21 |
| Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis PRP + HA injection, PRP injection, HA injection - Osteo Arthritis Knee | Not applicable | Recruiting | Istituto Ortopedico Rizzoli | 288 | 2025-12-11 | 2026-02-03 |
| Safety and Tolerability of StroMel™ in Subjects with Moderate to Severe Osteoarthritis of the Knee Joint StroMel - Osteo Arthritis Knee | Phase 1 / Phase 2 | Not yet recruiting | Akan Biosciences, LLC | 20 | 2025-10-01 | 2025-01-29 |
| Osteoarthritis Care Tools for Primary Care Providers OACareTools+ - Arthritis, Osteo Arthritis Knee | Not applicable | Completed | University of North Carolina, Chapel Hill | 75 | 2025-08-21 | 2026-09-24 |
| Effects of Blood Flow Restriction Combined With Electrostimulation After Knee Arthroplasty Blood flow restriction combined with electrostimulation. - Osteo Arthritis Knee | Not applicable | Active not recruiting | University of Pavia | 60 | 2025-07-10 | 2025-08-26 |
| The Role of Vitamin K on Knee Osteoarthritis Outcomes Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg - Osteo Arthritis Knee | Phase 1 / Phase 2 | Active not recruiting | Boston University | 49 | 2025-06-03 | 2026-09-21 |
| Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia Tailored Physical Activity Program - Pain, Chronic, Dementia, Mild | Not applicable | Not yet recruiting | Drexel University | 40 | 2025-06-02 | 2025-03-11 |
| An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint OA-SYS - Osteoarthritis, Osteo Arthritis Knee | Phase 2 | Recruiting | Ageless Biotech, Inc. | 400 | 2025-05-21 | 2025-09-18 |
| Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis Intermittent Hypoxia-Hyperoxia Therapy (IHHT), Conventional Physical Therapy, Normoxic Air Placebo - Osteo Arthritis Knee | Not applicable | Completed | Khyber Medical University Peshawar | 60 | 2025-05-15 | 2026-06-25 |
| In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA MicroPort Medial Pivot TKA, DePuy Attune PCR TKA - Total Knee Arthroplasty, Osteo Arthritis Knee | Withdrawn | The University of Tennessee, Knoxville | 2025-05-01 | 2026-05-05 | ||
| Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2) Sub Acute Whole Body Vibration Training - Whole Body Vibration, Osteo Arthritis Knee | Not applicable | Recruiting | Augusta University | 30 | 2025-04-25 | 2026-05-14 |
| Impact of Breathing and Yoga Poses on Kinesiophobia in Knee Osteoarthritis Patients Deep Breathing exercise, Three typical yoga poses - Kinesiophobia, Osteo Arthritis Knee | Not applicable | Completed | Saveetha University | 40 | 2024-12-20 | 2026-01-08 |
| SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization SakuraBead Resorbable Microspheres, Corticosteroid Injection - Osteo Arthritis Knee, Joint Diseases | Not applicable | Active not recruiting | CrannMed | 89 | 2024-11-28 | 2026-03-18 |
| The Effect of a 2-week Preoperative Vegan Diet Versus Omnivorous Diet on the Protein Turnover in the Osteoarthritic Knee Vegan diet, Omnivorous diet - Osteo Arthritis Knee, Protein Synthesis | Not applicable | Recruiting | Wageningen University | 40 | 2024-10-22 | 2025-04-01 |
| Radiographic Migration Analysis of the ATTUNE Cementless CR Fixed-Bearing Total Knee Replacement Attune Cementless - Osteo Arthritis Knee | Not applicable | Active not recruiting | Canadian Radiostereometric Analysis Network | 30 | 2024-10-21 | 2025-12-04 |
| Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches - Osteo Arthritis Knee, Arthritis | Phase 2 | Completed | ZetrOZ, Inc. | 307 | 2024-10-01 | 2026-06-30 |
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Osteoarthritis (68) · Osteoarthritis, Knee (38) · Pain (22) · Arthritis (14) · Chronic Pain (9) · Joint Diseases (8) · Osteoarthritis, Hip (8) · Pain, Postoperative (7) · Knee Injuries (6) · Motor Activity (6) · Anterior Cruciate Ligament Injuries (4) · Musculoskeletal Diseases (4) · Agnosia (3) · Arthritis, Rheumatoid (3) · Inflammation (3)
Musculoskeletal Diseases (100) · Joint Diseases (93) · Rheumatic Diseases (92) · Arthritis (86) · Pathological Conditions, Signs and Symptoms (51) · Signs and Symptoms (46) · Neurologic Manifestations (43) · Osteoarthritis (25) · Pain (18) · Pathologic Processes (14) · Nervous System Diseases (10) · Wounds and Injuries (9) · Leg Injuries (8) · Behavior (7) · Postoperative Complications (7)
Arthroplasty, Replacement, Knee (12) · Exercise (7) · Adrenal Cortex Hormones (4) · Sodium Chloride (4) · Congresses as Topic (3) · Physical Therapy Modalities (3) · Acetaminophen (2) · Bupivacaine (2) · Educational Status (2) · Low-Level Light Therapy (2) · Metformin (2) · Pharmaceutical Preparations (2) · Ropivacaine (2) · Saline Solution (2) · Tranexamic Acid (2)
Assiut University (5) · University of Calgary (5) · ZetrOZ, Inc. (4) · Corin (3) · NYU Langone Health (3) · Rothman Institute Orthopaedics (3) · University of North Carolina, Chapel Hill (3) · Campbell Clinic (2) · Eastern Mediterranean University (2) · Eli Lilly and Company (2) · Genascence Corporation (2) · Istituto Ortopedico Rizzoli (2) · Lipogems International spa (2) · Maharishi Markendeswar University (Deemed to be University) (2) · Majmaah University (2)
United States (76) · Canada (18) · Turkey (Türkiye) (17) · United Kingdom (12) · Egypt (9) · Netherlands (9) · Pakistan (7) · Spain (7) · India (6) · Poland (6) · Denmark (5) · France (5) · Italy (5) · Brazil (4) · Thailand (4)
Fares S Haddad (2) · George K Lewis, Ph.D. (2) · Hyochol Ahn, PhD, RN, MSN (2) · Leigh Callahan, PhD (2) · Richard Komistek, Ph.D. (2) · Shane A Shapiro (2) · A Howard (1) · Aamer Naeem, BSPT, PPDPT, MSOMPT, PhD* (1) · Adarsh K Srivastav, MPT (1) · Ahmed Fayez, Demonstrator (1) · Alberto Bazzocchi, MD, PhD (1) · Aleksi Reito, MD, PhD (1)
PMID 3068365, PMID 3741515, PMID 10561434, PMID 10685827, PMID 10796386, PMID 11014340, PMID 11092795, PMID 11869080, PMID 11886970, PMID 12029492, PMID 12081113, PMID 12465137, PMID 14613558, PMID 14667565, PMID 14722211, PMID 1563970, PMID 15676628, PMID 15880810, PMID 16263424, PMID 16949439, PMID 17022849, PMID 17308312, PMID 17381835, PMID 18542984, PMID 18687270, PMID 18687278, PMID 18843657, PMID 1991946, PMID 19930546, PMID 20305774, PMID 20418016, PMID 20476023, PMID 20603892, PMID 20861497, PMID 20972347, PMID 22200383, PMID 22421811, PMID 22488283, PMID 22491387, PMID 2287948, PMID 22925619, PMID 22982712, PMID 23140489, PMID 23144161, PMID 23157967, PMID 23337796, PMID 23516797, PMID 23831631, PMID 23998731, PMID 24284270
2019 (1), 2023 (1), K22NS102334 (1), K23AG081547 (1), K23AR082938 (1), P30AG059297 (1), R01AG060992 (1), R01NR019051 (1), R15NR018050 (1), U48DP006837 (1)