130 completed, 59 terminated, 46 active not recruiting, 40 unknown. 100 Not applicable, 33 Phase 4, 22 Phase 2, 14 Phase 1, 12 Phase 3.
Follow Osteonecrosis: new trials by email Literature Review of Osteonecrosis trials Research Report on Osteonecrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| DEXA Bone Density Analysis of the CoreHip® Prosthesis System Primary hip replacement with cementless stem - Primary Osteoarthritis, Cartilage Degeneration | Not applicable | Not yet recruiting | Aesculap AG | 40 | 2026-12-01 | 2026-10-16 |
| Effect of HBOT on Femoral Head Avascular Necrosis (AVN) Hyperbaric Oxygen Therapy - Osteonecrosis, Avascular Necrosis | Not applicable | Not yet recruiting | Yale University | 400 | 2026-12-01 | 2026-07-01 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| E-Type - Early Wear of Polyethylene Liners Used in DMC Total Hip Arthroplasty - Osteoarthritis, Osteonecrosis | Phase 4 | Recruiting | Uppsala University | 40 | 2026-10-08 | 2026-10-09 |
| Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial Total Hip Arthroplasty, Total Knee Arthroplasty, Unicondylar knee artrhoplasty - Knee Osteoarthritis, Hip Osteoarthritis | Not yet recruiting | Helse Møre og Romsdal HF | 300 | 2026-10-01 | 2026-09-22 | |
| Screening for Biomarkers of Osteonecrosis of the Femoral Head Osteonecrosis of the Femoral Head | Recruiting | The First Affiliated Hospital of Xinxiang Medical College | 300 | 2026-04-20 | 2026-04-22 | |
| Clinical Transformation of Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Avascular Necrosis of Femur Head Tissue-engineered bone - Avascular Necrosis of Femur Head | Not applicable | Recruiting | The First Affiliated Hospital of Xinxiang Medical College | 30 | 2026-04-20 | 2026-05-04 |
| Topical Oxygen Therapy for BRONJ Topical Blue®m application, PRF membrane placement - Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen | Not applicable | Active not recruiting | Mansoura University | 36 | 2026-04-01 | 2026-07-24 |
| Alendronate for Osteonecrosis in Adults With Sickle Cell Disease Alendronate Sodium - Sickle Cell Disease, Sickle Cell Anemia | Phase 2 | Recruiting | University of California, Davis | 30 | 2026-03-09 | 2026-07-16 |
| Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ Piezoelectric surgery, Conventional surgery - Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 34 | 2025-12-01 | 2025-09-22 |
| Early Feasibility Study of Cartilage Defect Repair ReNew Hip Implant - Osteoarthritis, Hip, Femoroacetabular Impingement | Not applicable | Active not recruiting | Cytex Therapeutics, Inc. | 15 | 2025-11-06 | 2026-09-16 |
| EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN)) EMPHASYS Cup with VHN - Osteoarthritis, Traumatic Arthritis | Not applicable | Recruiting | DePuy Orthopaedics | 118 | 2025-10-24 | 2026-09-25 |
| Z1 Hip System: Post-Market Clinical Follow Up Study Z1 Femoral Hip System - Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck | Recruiting | Zimmer Biomet | 300 | 2025-10-13 | 2026-10-16 | |
| Influence of Antiseptic Washes on Wound Healing Complications After THA lavage chlorhexidine, lavage povidone-iodine - Hip Osteoarthritis, Avascular Necrosis of Femur Head | Not applicable | Recruiting | F. Johannes Plate | 420 | 2025-10-09 | 2026-02-05 |
| Comparison of the Efficacy of Pericapsular Nerve Group Block Alone Versus Pericapsular Nerve Group Block Combined With Superior Cluneal and Superior Gluteal Nerve Blocks in Patients Undergoing Hip Surgery 15 ml Bupivacaine Hcl 0.25% injection, 20 mL bupivacaine 0.25% injection - Hip Osteoarthritis, Osteonecrosis of the Femoral Head | Not applicable | Enrolling by invitation | Ataturk University | 60 | 2025-09-01 | 2025-12-08 |
| Investigation of the Effect of Hyperbaric Oxygen Therapy in Patients With Avascular Necrosis Avascular Necrosis of Femur Head | Active not recruiting | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 20 | 2025-08-19 | 2025-08-26 | |
| Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert EVOLUTION® NitrX™ - Osteoarthitis, Arthritis Knee | Active not recruiting | MicroPort Orthopedics Inc. | 100 | 2025-08-18 | 2026-02-06 | |
| Robotic Arm-assisted THA Vs. Conventional THA in Legg-Calvé-Perthes Disease robotic arm-assisted total hip replacement, conventional total hip replacement - Legg-Calvé-Perthes Disease | Not applicable | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2025-07-28 | 2025-08-14 |
| Clinical Outcomes of Primary Cementless Total Hip Arthroplasty Using the Collarless Actis Stem Collarless Actis femoral stem - Osteoarthritis, Hip, Femur Head Necrosis | Not applicable | Recruiting | Seoul National University Bundang Hospital | 210 | 2025-06-18 | 2026-09-18 |
Showing 20 of 334. Sign in to see all of them.
Osteoarthritis (137) · Arthritis, Rheumatoid (102) · Femur Head Necrosis (64) · Osteoarthritis, Hip (42) · Hip Dislocation, Congenital (35) · Arthritis (34) · Legg-Calve-Perthes Disease (25) · Joint Diseases (23) · Femoral Neck Fractures (18) · Hip Fractures (16) · Bisphosphonate-Associated Osteonecrosis of the Jaw (14) · Osteoarthritis, Knee (14) · Slipped Capital Femoral Epiphyses (14) · Collagen Diseases (13)
Bone Diseases (330) · Musculoskeletal Diseases (329) · Pathological Conditions, Signs and Symptoms (323) · Pathologic Processes (322) · Necrosis (321) · Rheumatic Diseases (190) · Joint Diseases (186) · Arthritis (167) · Skin and Connective Tissue Diseases (113) · Connective Tissue Diseases (111) · Immune System Diseases (111) · Autoimmune Diseases (104) · Wounds and Injuries (64) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (50)
Arthroplasty, Replacement, Hip (22) · Arthroplasty, Replacement, Knee (6) · Zoledronic Acid (6) · Alendronate (3) · Hyperbaric Oxygenation (3) · Saline Solution (3) · Arthroplasty, Replacement, Shoulder (2) · Arthroscopy (2) · Bupivacaine (2) · Magnetic Resonance Imaging (2) · Magnetic Resonance Spectroscopy (2) · Observation (2) · Osteotomy (2) · Pentoxifylline (2) · Propofol (2)
Zimmer Biomet (49) · DePuy International (17) · Medacta International SA (15) · MicroPort Orthopedics Inc. (15) · DePuy Orthopaedics (11) · Biomet Orthopedics, LLC (9) · Aesculap AG (7) · Corin (7) · Smith & Nephew, Inc. (7) · Stryker Trauma and Extremities (6) · Encore Medical, L.P. (5) · Ewha Womans University (4) · Mayo Clinic (3) · Seoul National University Bundang Hospital (3) · St. Jude Children's Research Hospital (3)
United States (110) · Germany (35) · France (32) · United Kingdom (32) · Italy (22) · Canada (21) · Spain (20) · China (18) · Switzerland (16) · Belgium (15) · South Korea (13) · Austria (11) · Norway (9) · Netherlands (8) · Turkey (Türkiye) (7)
Hassan Achakri (8) · Hillary Overholser (7) · Paola Vivoda (6) · Emilie Rohmer (5) · Kenneth J Beres, MD (4) · Paul Beaule, MD (4) · Rebecca Gibson (3) · Russell Schenck, PhD (3) · Dave Whalen, BS, DC (2) · Hamid Gourabi, PhD (2) · Kathy Trier, Ph.D. (2) · Li Cao (2) · Nasser Aghdami, MD,PhD (2) · Olga Di Fede, Professor (2) · Oyebimpe O Adesina, MD, MS (2)
PMID 35866376, PMID 10913211, PMID 11095169, PMID 11728921, PMID 11810611, PMID 15615504, PMID 1613218, PMID 16525984, PMID 17418764, PMID 18331175, PMID 18547784, PMID 19915292, PMID 19934701, PMID 20097039, PMID 20145794, PMID 20458640, PMID 20971577, PMID 21082586, PMID 21411700, PMID 21643924, PMID 21964452, PMID 22127729, PMID 23079689, PMID 23234268, PMID 2348055, PMID 23695220, PMID 24474088, PMID 24721376, PMID 24908421, PMID 25315149, PMID 25769789, PMID 25873151, PMID 26021713, PMID 26396935, PMID 2643938, PMID 26566324, PMID 28988340, PMID 29432651, PMID 29765616, PMID 29788942, PMID 30224340, PMID 30415580, PMID 30507834, PMID 30786996, PMID 31122988, PMID 31555714, PMID 32419366, PMID 32678055, PMID 32871293, PMID 33381769
K23HL148310 (2), 2014 (1), 2018 (1), K08CA250418 (1), K23DE020197 (1), R01AR052293 (1), U01AR080993 (1)