Vitamin D Deficiency: Clinical Trials

645 completed, 141 unknown, 48 recruiting, 43 terminated. 356 Not applicable, 110 Phase 2, 107 Phase 4, 86 Phase 3, 50 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	356	Completed 254, Unknown 45, Recruiting 16, Terminated 14, Withdrawn 10, Not yet recruiting 8, Active not recruiting 7, Enrolling by invitation 1, Suspended 1
Phase 2	110	Completed 73, Unknown 12, Withdrawn 9, Terminated 7, Recruiting 5, Active not recruiting 2, Not yet recruiting 1, Suspended 1
Phase 4	107	Completed 76, Unknown 17, Terminated 7, Active not recruiting 3, Recruiting 2, Not yet recruiting 1, Withdrawn 1
Phase 3	86	Completed 64, Unknown 9, Terminated 6, Withdrawn 5, Active not recruiting 1, Recruiting 1
Phase 1	50	Completed 34, Unknown 8, Terminated 4, Withdrawn 2, Recruiting 1, Suspended 1
Early Phase 1	18	Completed 9, Unknown 5, Recruiting 2, Terminated 2

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D. Vitamin D3, Calcium, and Vitamin C - Hypovitaminosis D	Not applicable	Not yet recruiting	Atlantic Health System	200	2027-01-01	2026-10-20
Vitamin D Status and Its Influencing Factors in Zhejiang Province: A Multicenter Cross-Sectional Study Vitamin D Deficiency		Enrolling by invitation	First Affiliated Hospital of Zhejiang University	10000	2026-10-31	2026-10-08
Osteoporosis & Renal Disease: Research in Primary Health Care Services Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA) - Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder		Not yet recruiting	Universidade do Porto	622	2026-10-01	2026-09-30
Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS) Vitamin D 4000IU daily, Placebo - Polycystic Ovarian Syndrome in Adolescent Females, Vitamin D Deficiency	Not applicable	Recruiting	Yale University	60	2026-09-01	2026-08-20
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis intra-oral 3D optical impression - Osteogenesis Imperfecta, Rare Bone Disorders	Not applicable	Not yet recruiting	University Hospital, Bordeaux	240	2026-09-01	2026-06-24
Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma Bronchial Asthma, Vitamin D Deficiency		Not yet recruiting	Sinai University	134	2026-07-26	2026-07-29
Vitamin D Status and Lipid Profile in Obese Adults With Type 2 Diabetes Type 2 Diabetes Mellitus, Obesity		Not yet recruiting	Sinai University	150	2026-07-25	2026-07-27
Treatment Patterns, Biochemical Profiles and Clinical Outcomes in Adults With X-Linked Hypophosphatemia No treatment given - X-linked Hypophosphatemia (XLH)		Withdrawn	Novo Nordisk A/S		2026-07-07	2026-08-28
Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Hypertension	Phase 2	Not yet recruiting	University of Texas Southwestern Medical Center	60	2026-07-01	2026-06-22
Medium Cut-Off and High-Flux Membranes on Mineral and Bone Metabolism in Hemodialysis Patients Medium Cut-Off Hemodialysis Membrane, High-Flux Hemodialysis Membrane - End Stage Kidney Disease (ESKD), Hemodialysis	Not applicable	Active not recruiting	Gazi University	30	2026-07-01	2026-09-14
The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases Non-surgical periodontal treatment, Vitamin D administration, Oral Hygiene Education and Patient Motivation - Periodontal Diseases, Gingivitis	Not applicable	Recruiting	Recep Tayyip Erdogan University Training and Research Hospital	120	2026-06-03	2026-06-10
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections Serum 25-Hydroxyvitamin D Assessment - Acute Respiratory Infections, Critical Illness in Children		Not yet recruiting	Assiut University	63	2026-06-01	2026-05-08
The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency Urotherapy - Overactive Bladder, Vitamin D Deficiency	Not applicable	Not yet recruiting	Tarik Emre Sener	52	2026-05-01	2026-04-07
Calcium Isotope Ratios to Assess Calcium Bone Balance in Dialysis Children Receiving Cinacalcet Supplementary blood samples and urines samples - Children Over 3 Undergoing Dialysis With Secondary Hyperparathyroidism		Recruiting	Hospices Civils de Lyon	20	2026-04-29	2026-05-22
Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D Deficiency Vitamin D2, Calcitriol - Cholestatic Liver Disease, Chronic Liver Disease (CLD)	Phase 4	Recruiting	Chulalongkorn University	54	2026-04-28	2026-08-03
Effect of Vitamin D Supplementation on Brain Waves in Female Major Depressive Disorder Patients With Hypovitaminosis D Dietary vitamin D - Major Depressive Disorder (MDD), Hypovitaminosis D	Not applicable	Enrolling by invitation	Bangladesh Medical University	34	2026-04-25	2026-05-12
ALPCO 25(OH) Vitamin D CLIA Kit - Fresh Versus Frozen Serum and Plasma Stability Study ALPCO 25(OH) Vitamin D CLIA Kit - Vitamin D Deficiency, Vitamin D Insufficiency		Enrolling by invitation	American Laboratory Products Company	80	2026-04-18	2026-05-04
Association Between Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency . Vitamin D - Benign Paroxysmal Positional Vertigo (BPPV)		Recruiting	Sohag University	160	2026-04-01	2026-06-18
Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency Vitamin D Deficiency		Recruiting	Istanbul Physical Medicine Rehabilitation Training and Research Hospital	24	2026-03-05	2026-10-06
High-Dose vs Standard Ergocalciferol for Vitamin D Normalization in Aggressive Non-Hodgkin Lymphoma High-Dose Loading Ergocalciferol, Standard Weekly Ergocalciferol - Vitamin D 25-Hydroxylase Deficiency, Lymphoma Non-Hodgkin	Not applicable	Not yet recruiting	Phramongkutklao College of Medicine and Hospital	52	2026-02-01	2026-01-26

Showing 20 of 955. Sign in to see all of them.

Narrower conditions

Chronic Kidney Disease-Mineral and Bone Disorder (73)  ·  Familial Hypophosphatemic Rickets (49)  ·  Renal Insufficiency, Chronic (49)  ·  Obesity (48)  ·  Insulin Resistance (37)  ·  Rickets (36)  ·  Osteomalacia (34)  ·  Osteoporosis (34)  ·  Bone Diseases, Metabolic (26)  ·  Hyperparathyroidism, Secondary (26)  ·  Bone Diseases (24)  ·  Diabetes Mellitus (23)  ·  Kidney Failure, Chronic (23)  ·  Diabetes Mellitus, Type 2 (20)

Broader conditions

Nutritional and Metabolic Diseases (955)  ·  Deficiency Diseases (954)  ·  Nutrition Disorders (953)  ·  Avitaminosis (950)  ·  Malnutrition (947)  ·  Metabolic Diseases (302)  ·  Pathological Conditions, Signs and Symptoms (240)  ·  Musculoskeletal Diseases (224)  ·  Urogenital Diseases (215)  ·  Female Urogenital Diseases and Pregnancy Complications (204)  ·  Calcium Metabolism Disorders (186)  ·  Bone Diseases (185)  ·  Bone Diseases, Metabolic (180)  ·  Female Urogenital Diseases (180)  ·  Endocrine System Diseases (169)

Interventions

Cholecalciferol (305)  ·  Vitamin D (178)  ·  Ergocalciferols (54)  ·  burosumab (22)  ·  Calcium (21)  ·  Calcitriol (18)  ·  Blood Specimen Collection (17)  ·  Calcifediol (15)  ·  Calcium Carbonate (14)  ·  asfotase alfa (10)  ·  Sugars (8)  ·  Dietary Supplements (6)  ·  paricalcitol (6)  ·  Metformin (5)  ·  Cinacalcet (4)

Sponsors

University of Wisconsin, Madison (14)  ·  Alexion Pharmaceuticals, Inc. (13)  ·  Kyowa Kirin Co., Ltd. (11)  ·  Massachusetts General Hospital (11)  ·  University of Aarhus (11)  ·  Ain Shams University (10)  ·  Creighton University (10)  ·  Medical University of Graz (10)  ·  Cairo University (9)  ·  Boston University (8)  ·  Hospices Civils de Lyon (8)  ·  Mayo Clinic (8)  ·  National Taiwan University Hospital (8)  ·  Second Affiliated Hospital of Wenzhou Medical University (8)  ·  Assiut University (7)

Countries

United States (310)  ·  Turkey (Türkiye) (48)  ·  United Kingdom (47)  ·  China (41)  ·  Egypt (40)  ·  Canada (35)  ·  France (34)  ·  Denmark (29)  ·  Italy (22)  ·  Israel (20)  ·  Germany (19)  ·  Austria (18)  ·  Mexico (17)  ·  Sweden (17)  ·  Japan (14)

Top investigators

Mahmoud S Abu-Samak, PhD (4)  ·  Michael F Holick, PhD, MD (4)  ·  Muhammad M Hammami, MD, PhD (4)  ·  Neil Binkley, M.D. (4)  ·  Benjamin U Nwosu, MD (3)  ·  Joel Melnick, MD (3)  ·  Laura A Armas, MD (3)  ·  Mary S McCarthy, PhD (3)  ·  Patricia Loranca-Moreno, M.D., M.Sc. (3)  ·  Ambika Ashraf (2)  ·  Amy Zhang, PhD (2)  ·  Bess Dawson-Hughes, M.D. (2)  ·  Carlos Bernal-Mizrachi, MD (2)  ·  Carol L Wagner, MD (2)

Results publications

PMID 33305842, PMID 39151033, PMID 39077939, PMID 26529632, PMID 40576086, PMID 21646368, PMID 32417537, PMID 32721016, PMID 32762706, PMID 35018442, PMID 40962182, PMID 18400738, PMID 22586483, PMID 22780885, PMID 23527013, PMID 25777546, PMID 25919461, PMID 26151421, PMID 27699270, PMID 32390123, PMID 33158822, PMID 36854566, PMID 11146455, PMID 11158062, PMID 11500705, PMID 12520530, PMID 12605179, PMID 14688154, PMID 14693936, PMID 14985208, PMID 15181052, PMID 15930998, PMID 16163440, PMID 16493517, PMID 16541901, PMID 17177140, PMID 17468488, PMID 17591525, PMID 17634462, PMID 17693256, PMID 17927502, PMID 18180395, PMID 18190464, PMID 18238736, PMID 18302509, PMID 18326608, PMID 18362359, PMID 18385391, PMID 18397701, PMID 18400741

NIH funding

2018 (3), 2008 (2), 2009 (2), 2014 (2), 2017 (2), 2019 (2), K23DK073356 (2), R01DK084986 (2), 1RC1HD063562 (1), 1UL1TR001863-01 (1), 2015 (1), 2016 (1), K23AG040708 (1), K23AR050995 (1), K23DK081677 (1)