7 completed, 5 terminated, 4 recruiting, 4 unknown. 8 Phase 4, 6 Not applicable, 5 Phase 2, 4 Phase 1, 2 Phase 3.
Follow Metolazone: new trials by email Literature Review of Metolazone trials Research Report on Metolazone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Add-on Diuretics in Acute Decompensated Heart Failure empagliflozin, Acetazolamide, metolazone - Acute Decompensated Heart Failure | Phase 2 | Recruiting | Tanta University | 66 | 2026-02-01 | 2026-02-04 |
| Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure Acetazolamide, Metolazone - Acute Decompensated Heart Failure, Heart Failure, Diastolic | Not applicable | Recruiting | University of Health Sciences Lahore | 320 | 2025-10-11 | 2025-10-03 |
| Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload Acetazolamide, Metolazone 2.5 MG, Double-placebo - Acute Heart Failure | Phase 4 | Recruiting | Johannes Grand | 939 | 2024-09-05 | 2026-08-14 |
| Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload Acetazolamide, Metolazone, IV Loop Diuretics - Acute Decompensated Heart Failure, Volume Overload | Phase 4 | Unknown | Cairo University | 110 | 2024-07-01 | 2024-07-24 |
| Role of Active Deresuscitation After Resuscitation: Furosemide Injection, Metolazone Tablets - Fluid Overload, Critical Illness | Phase 2 | Unknown | Unity Health Toronto | 120 | 2024-05-01 | 2024-03-22 |
| Acetazolamide or Metolazone in Acute Heart Failure Acetazolamide 250 MG, Metolazone 2.5 MG, Furosemide Injection - Heart Failure Acute, Decompensated Heart Failure | Not applicable | Not yet recruiting | Clinica Alemana de Santiago | 1050 | 2024-05-01 | 2024-03-18 |
| Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance Furosemide, Metolazone, Acetazolamide - Acute Heart Failure, Diuretic Resistance | Phase 4 | Terminated | Stadtspital Zürich | 13 | 2023-10-10 | 2025-02-14 |
| DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance Dapagliflozin 10 MG Oral Tablet, Metolazone Tablets - Heart Failure | Phase 3 | Unknown | NHS Greater Glasgow and Clyde | 61 | 2021-04-27 | 2023-04-10 |
| Ertugliflozin in Chronic Heart Failure Ertugliflozin, Metolazone, Placebo - Heart Failure | Phase 2 | Recruiting | Yale University | 60 | 2021-03-10 | 2025-10-08 |
| Efficacy of Diuretics in Kidney Disease Metolazone, Placebo - Chronic Kidney Disease, End Stage Renal Disease | Phase 2 | Terminated | Stanford University | 17 | 2021-03-01 | 2025-06-05 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Sequential Nephron Blockade in Acute Heart Failure Metolazone, Loop Diuretics - Acute Heart Failure | Phase 3 | Unknown | Policlinico Casilino ASL RMB | 310 | 2019-10-01 | 2019-11-19 |
| Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing Metolazone 60 minutes prior to furosemide, Metolazone concurrently with furosemide - Fluid Overload, Heart Failure Acute | Phase 4 | Terminated | University of Maryland, Baltimore | 3 | 2019-01-01 | 2021-10-22 |
| Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance Metolazone Oral Tablet, Chlorothiazide Injection - Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 4 | Terminated | University of Virginia | 5 | 2018-06-01 | 2021-02-16 |
| Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure tolvaptan, Chlorothiazide, Metolazone - Heart Failure | Phase 4 | Completed | Vanderbilt University | 60 | 2016-02-01 | 2019-11-08 |
| AiDing Diuresis wIth Tolvaptan (ADD-IT) Tolvaptan 30 mg + IV Diuretics, Metolazone 5 mg + IV Diuretics, 2.5 times the Diuretics Dose - Cardiomyopathy, Congestive Heart Failure | Phase 1 | Completed | Emory University | 14 | 2016-01-01 | 2019-03-27 |
| Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure Placebo, Metolazone - Acute Decompensated Heart Failure | Phase 2 | Withdrawn | Scripps Health | 2014-03-01 | 2022-12-01 | |
| A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II) Furosemide, metolazone, furosemid/spironolactone - Congestive Heart Failure | Not applicable | Withdrawn | Yonsei University | 2014-01-01 | 2016-09-07 | |
| A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1) furosemide/no spironolactone, metolazone/no spironolactone, furosemid/spironolactone - Congestive Heart Failure | Not applicable | Withdrawn | Yonsei University | 2013-03-01 | 2014-02-19 |
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Heart Failure (8) · Edema (4) · Cardiovascular Diseases (2) · Hypertension (2) · COVID-19 (1) · Cardiomyopathies (1) · Coronavirus Infections (1) · Critical Illness (1) · Heart Failure, Diastolic (1) · Heart Failure, Systolic (1) · Hypernatremia (1) · Kidney Failure, Chronic (1) · Multiple Trauma (1) · Renal Insufficiency, Chronic (1) · Respiratory Distress Syndrome (1)
Mylan Pharmaceuticals Inc (3) · Yonsei University (2) · Cairo University (1) · Clinica Alemana de Santiago (1) · Emory University (1) · Johannes Grand (1) · NHS Greater Glasgow and Clyde (1) · National University of Ireland, Galway, Ireland (1) · Oregon Health and Science University (1) · Policlinico Casilino ASL RMB (1) · Scripps Health (1) · Stadtspital Zürich (1) · Stanford University (1) · Tanta University (1) · Unity Health Toronto (1)
United States (14) · Egypt (2) · Canada (1) · Denmark (1) · Ireland (1) · Italy (1) · Pakistan (1) · Switzerland (1) · United Kingdom (1)
Adam P Bress, PharmD, MS (1) · Brent Reed, PharmD (1) · Dalia A Gomaa, MSc in clinical pharmacy (1) · Dan Hagg, MS MD (1) · David Steiger, JD MD (1) · Divya Gupta, MD (1) · Dorian Williams, M.D. (1) · Gennaro Cice, MD (1) · James T Heywood, MD (1) · Jeffrey Testani, MD (1) · Jo E. Rodgers, PharmD (1) · Johannes Grand, MD, Phd, MPH (1) · John C Marshall, MD (1) · John McMurray, MBChB (1) · John William McEvoy, MBBCh MHS (1)