18 completed, 5 unknown, 3 terminated, 1 enrolling by invitation. 16 Not applicable, 5 Phase 2, 3 Phase 3, 3 Phase 4, 2 Phase 1.
Follow Propylene Glycol: new trials by email Literature Review of Propylene Glycol trials Research Report on Propylene Glycol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial to Assess the Pharmacokinetic Profile of Propylene Glycol (PG) in Healthy Adults Following PG Exposure Propylene glycol - Healthy, Pharmacokinetic Profile | Not applicable | Completed | American Beverage Association | 30 | 2026-07-09 | 2026-09-29 |
| Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5% - Dry Eye Disease (DED) | Phase 4 | Recruiting | Andover Research Eye Institute | 60 | 2026-06-03 | 2026-06-30 |
| Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles - Pain, Postoperative, Root Resorption | Not applicable | Enrolling by invitation | Ain Shams University | 108 | 2025-07-01 | 2026-09-29 |
| Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye Preservative-free sterile ophthalmic solution, with 0.3% propylene glycol and 0.4% polyethylene glycol (400) - Dry Eye Disease | Unknown | Tecnoquimicas | 132 | 2023-03-15 | 2023-12-08 | |
| 3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars 3Mixtatin paste: Simvastatin mixed with modified triple antibiotic, 3Mix: Modified triple antibiotic mix in propylene glycol - Necrotic Primary Molars | Not applicable | Unknown | Cairo University | 24 | 2023-03-01 | 2023-01-10 |
| Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles Double antibiotic paste mixed with chitosan nanoparticles, Double antibiotic paste mixed with propylene glycol - Resorption of Tooth or Root | Phase 3 | Unknown | Ain Shams University | 36 | 2021-12-01 | 2021-11-08 |
| Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars Hyaluronic acid, Propylene glycol - Resorption of Tooth or Root | Phase 3 | Unknown | Ain Shams University | 36 | 2021-11-01 | 2021-11-11 |
| A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19 Ambrisentan, Placebo - Covid19, Hypoxemia | Phase 2 | Terminated | Noorik Biopharmaceuticals AG | 88 | 2021-02-08 | 2023-03-21 |
| Clinical Trial to Compare the Safety and Efficacy of Nanodrop® Nanodrop®, Systane Balance - Dry Eye | Phase 1 / Phase 2 | Completed | Laboratorios Sophia S.A de C.V. | 126 | 2020-12-01 | 2025-07-16 |
| Post-Operative Constipation Following Total Knee Arthroplasty Propylene Glycol, Docusate Sodium - Constipation | Phase 2 | Completed | The Cleveland Clinic | 154 | 2020-02-21 | 2022-01-19 |
| Acute Effects of Propylene Glycol/Glycerol Intake on Blood Parameters Propylene glycol and Glycerol intake, Mimicking intake - Metabolic Complication | Not applicable | Completed | Université Libre de Bruxelles | 24 | 2018-01-15 | 2019-04-17 |
| A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients Reference cigarette, Cigarette with carob bean extract, Cigarette with cocoa powder - Healthy Volunteers, Smoking | Not applicable | Completed | British American Tobacco (Investments) Limited | 40 | 2017-09-12 | 2022-12-07 |
| Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL], Propylene Glycol - Vitamin D Deficiency, Polytrauma | Phase 1 / Phase 2 | Suspended | New York City Health and Hospitals Corporation | 60 | 2017-07-01 | 2019-04-04 |
| Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract Ocimum sanctum, Chlorhexidine Gluconate, Propylene Glycol - Periodontal Diseases, Gingivitis | Not applicable | Completed | Government College of Dentistry, Indore | 90 | 2017-04-12 | 2018-04-17 |
| Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors Propylene Glycol, vegetable glycerin, PG+VG - Healthy Lifetime Non-smokers | Not applicable | Terminated | University of Miami | 30 | 2017-02-22 | 2020-01-14 |
| Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV) PRO-087, Systane Ultra, Systane Ultra Preservative Free - Dry Eye Syndrome | Phase 4 | Completed | Laboratorios Sophia S.A de C.V. | 326 | 2016-10-13 | 2019-10-31 |
| Clinical Outcomes Following Treatment With SYSTANE® BALANCE Propylene glycol, 0.6% eye drops, Lubricant eye drops - Dry Eye | Not applicable | Completed | Alcon Research | 308 | 2016-07-29 | 2019-06-19 |
| Clinical Evaluation of Systane® Balance in Dry Eye Subjects Propylene Glycol 0.6% eye drops - Dry Eye | Not applicable | Terminated | Alcon Research | 14 | 2015-11-26 | 2018-10-31 |
| Comparison of Topical Minoxidil 5% in Ethanol Plus Propylene Glycol Versus Minoxidil 5% in Ethanol Alone in Treatment of Women With Female Pattern Hair Loss Topical minoxidil 5% in 90% ethanol and 5% propylene glycol, Topical minoxidil 5% in pure ethanol alone, Placebo (Ethanol) - Female Pattern Hair Loss | Phase 4 | Completed | Sohag University | 60 | 2015-05-30 | 2019-09-26 |
| Clinical Evaluation of Systane® Gel Drops in Dry Eye Subjects Polyethylene Glycol, 0.4%, Propylene Glycol, 0.3% eye drops - Dry Eye | Not applicable | Completed | Alcon Research | 207 | 2015-05-14 | 2018-07-02 |
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Dry Eye Syndromes (12) · COVID-19 (1) · Constipation (1) · Dental Pulp Necrosis (1) · Gingivitis (1) · Hypoxia (1) · Marijuana Abuse (1) · Meibomian Gland Dysfunction (1) · Multiple Trauma (1) · Musculoskeletal Diseases (1) · Pain, Postoperative (1) · Periodontal Diseases (1) · Periodontitis (1) · Persistent Infection (1) · Respiratory Distress Syndrome (1)
Alcon Research (5) · Ain Shams University (3) · Laboratorios Sophia S.A de C.V. (3) · American Beverage Association (1) · Andover Research Eye Institute (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · British American Tobacco (Investments) Limited (1) · Cairo University (1) · Centre for Addiction and Mental Health (1) · Erasme University Hospital (1) · Government College of Dentistry, Indore (1) · New York City Health and Hospitals Corporation (1) · Noorik Biopharmaceuticals AG (1) · Ophthalmic Consultants of Connecticut (1) · Sohag University (1)
United States (7) · Mexico (3) · Belgium (2) · Canada (2) · India (2) · Argentina (1) · Bangladesh (1) · Colombia (1) · Croatia (1) · Egypt (1) · Spain (1) · United Kingdom (1)
Amira S Badran, PhD (1) · Anne Delbaere, Ph.D. (1) · Bernard Le Foll (1) · David Crowley (1) · Dr. Subhash Garg, M.D.S. (1) · Eric Donnenfeld, M.D. (1) · Jerry R Paugh, OD, PhD (1) · John J Voorhees, MD (1) · Johnston Stewart, MB (1) · Kathleen Gonzalez, RN, MSN (1) · Leopoldo Baiza, MD (1)
PMID 18794456, PMID 27645318, PMID 37077305, PMID 37708528, PMID 42251079