107 completed, 54 unknown, 35 recruiting, 14 not yet recruiting. 126 Not applicable, 14 Phase 2, 9 Phase 3, 9 Phase 4, 7 Phase 1.
Follow Mouth Abnormalities: new trials by email Literature Review of Mouth Abnormalities trials Research Report on Mouth Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Indications and Evaluation of Microfat Grafting in Cleft Lip Nasal Deformities Microfat grafting - Cleft Lip and Nose | Not applicable | Not yet recruiting | Assiut University | 30 | 2027-05-01 | 2026-10-29 |
| Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block - Cleft Lip, Cleft Palate +/- Lip | Not applicable | Not yet recruiting | Children's National Research Institute | 144 | 2026-12-16 | 2026-10-23 |
| Donor Site Morbidity and Buccinator Muscle Integrity After Buccinator Myomucosal Flap Surgery in Patients With Velopharyngeal Incompetence Bilateral posteriorly based buccinator myomucosal flap surgery - Donor Site, Morbidity | Recruiting | Sohag University | 15 | 2026-10-04 | 2026-10-06 | |
| Furlow With Buccinator and Fistula Formation furlow with buccinator, two flap palatoplasty - Cleft Palate | Not applicable | Not yet recruiting | Fayoum University | 20 | 2026-09-25 | 2026-09-25 |
| Effect of Velopharyngeal Gap Size on Laryngeal Morphology and Vocal Function in Children With VPI Velopharyngeal Insufficiency | Not yet recruiting | Assiut University | 92 | 2026-09-25 | 2026-09-24 | |
| Cleft Lip and Palate Treatment Outcomes Study Cleft Lip and Palate | Not yet recruiting | University of Florida | 100 | 2026-08-01 | 2026-07-07 | |
| Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF in Cleft Palate Standard palatoplasty ( control), Platelet _ Rich Fibrin ( PRF), gentamicin_ loaded PRF - Cleft Palate, Unilateral Cleft Palate | Not applicable | Recruiting | Al-Thawra Modern General Hospital | 90 | 2026-08-01 | 2026-08-07 |
| Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip Non-linear based phonological speech intervention, Linear-based speech intervention - Cleft Palate +/- Lip | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 12 | 2026-07-24 | 2026-07-09 |
| Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring Standard General Anesthesia per Institutional Protocol - Cleft Palate, Cleft Lip | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 150 | 2026-06-27 | 2026-06-16 | |
| MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair Modified Furlow Palatoplasty combined with buccinator myomucosal flap - Cleft Palate, Cleft Palate, Unilateral, Complete | Not applicable | Not yet recruiting | Cairo University | 10 | 2026-06-01 | 2026-04-07 |
| Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients Velopharyngeal Insufficiency, Swallowing | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 28 | 2026-05-01 | 2026-03-20 | |
| Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study Pharyngeal Wall Augmentation Injection - Velopharyngeal Insufficiency, Head and Neck Cancer | Not applicable | Recruiting | Vanessa Torrecillas | 20 | 2026-03-24 | 2026-04-28 |
| Speech Intervention Via Telepractice for Children With Repaired Cleft Palate Speech therapy via teleprace, Face-to-face speech therapy - Cleft Palate Children, Speech Sound Disorder | Not applicable | Not yet recruiting | Texas Tech University Health Sciences Center | 64 | 2026-03-02 | 2026-02-27 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma AdMSC, Placebo - Systemic Scleroderma | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 50 | 2026-01-01 | 2026-01-08 |
| Effects of AlignBabyCleft (ABaCleft) Appliance. Orthodontic appliance to carry out dentoalveolar movement - Cleft Lip, Cleft Palate | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 30 | 2025-11-21 | 2025-04-25 |
| Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation. Early intervention for language, articulation and palatal function skills - Cleft Lip and Cleft Palate, Cleft Lip Palate | Not applicable | Not yet recruiting | Old Dominion University | 200 | 2025-10-21 | 2025-10-22 |
| Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery ketamine, Nalbuphine, Dexmedetomidine - Orofacial Clefts, Cleft Lip and Palate | Not applicable | Recruiting | University Medical Centre Ljubljana | 60 | 2025-09-01 | 2026-01-14 |
| Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate Mailing and completing CLEFT-Q and NOSE questionnaires - Cleft Lip and Cleft Palate | Recruiting | University Hospital, Montpellier | 80 | 2025-07-09 | 2025-07-22 | |
| Clinical Effectiveness of a Patient-tailored Orthosis Based on 3-dimensional (3D) Scanner Modeling and 3D Printing Technology for Microstomia Caused by Burns : Pilot Study patient's tailored mouthpiece fitting - Burn, 3D Printing | Not applicable | Enrolling by invitation | Hangang Sacred Heart Hospital | 10 | 2025-07-05 | 2025-12-04 |
Showing 20 of 236. Sign in to see all of them.
Cleft Lip (144) · Cleft Palate (114) · Velopharyngeal Insufficiency (20) · Congenital Abnormalities (8) · Microstomia (8) · Communication Disorders (7) · Cicatrix (6) · Retrognathia (6) · Speech (5) · Agnosia (4) · Craniofacial Abnormalities (4) · Pain, Postoperative (4) · Otitis Media (3) · Scleroderma, Systemic (3) · Sleep Apnea, Obstructive (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (236) · Mouth Diseases (236) · Stomatognathic Diseases (235) · Stomatognathic System Abnormalities (235) · Congenital Abnormalities (228) · Lip Diseases (144) · Musculoskeletal Diseases (120) · Musculoskeletal Abnormalities (119) · Craniofacial Abnormalities (116) · Jaw Diseases (116) · Jaw Abnormalities (115) · Maxillofacial Abnormalities (114) · Pathological Conditions, Signs and Symptoms (39) · Otorhinolaryngologic Diseases (29)
Bupivacaine (5) · Nasoalveolar Molding (5) · Saline Solution (5) · Alveolar Bone Grafting (4) · Dexmedetomidine (4) · Orthognathic Surgery (4) · Acetaminophen (3) · Sodium Chloride (3) · Surveys and Questionnaires (3) · Botulinum Toxins, Type A (2) · Fentanyl (2) · Folic Acid (2) · Ketamine (2) · Ketorolac (2) · Levobupivacaine (2)
Cairo University (26) · Assiut University (13) · Chang Gung Memorial Hospital (6) · Fayoum University (6) · Faculty of Dental Medicine for Girls (5) · The University of Texas Health Science Center, Houston (5) · Mansoura University (4) · University Ghent (4) · University Hospital, Basel, Switzerland (4) · University of Florida (4) · Assistance Publique - Hôpitaux de Paris (3) · Centre Hospitalier Universitaire, Amiens (3) · Duke University (3) · Hospital Sirio-Libanes (3) · Oslo University Hospital (3)
Egypt (55) · United States (48) · France (18) · Belgium (8) · Brazil (8) · Canada (8) · Sweden (6) · Turkey (Türkiye) (6) · United Kingdom (6) · Norway (5) · Taiwan (5) · Switzerland (4) · Czechia (3) · Germany (3) · Hong Kong (3)
Cuneyt M Alper, MD (2) · Jeff Murray, M.D. (2) · Kristiane Van Lierde, PhD (2) · Stephen Yen, DMD, PhD (2) · Adel F Hassan, Phd (1) · Ahmed M Ali, lecturer (1) · Alexander C Allori, MD, MPH (1) · Allen Wilcox, M.D. (1) · Amany M. Diab, PhD (1) · Andrzej Brudnicki, MD DDS PhD (1) · Ashley Lentz, MD (1) · Axel Sauter, MD PhD (1)
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R21DC017553 (2), 2014 (1), P50DC007667 (1), R01DC011524 (1), R01DE010437 (1), R01DE013814 (1), R01DE022438 (1), R01DE028554 (1), R21HL087819 (1), U01DE017958 (1), U01DE018837 (1), U01DE020057 (1), U01HD040561 (1)