113 completed, 45 unknown, 29 recruiting, 11 terminated. 95 Not applicable, 31 Phase 2, 20 Phase 3, 14 Phase 1, 6 Phase 4.
Follow Lip Diseases: new trials by email Literature Review of Lip Diseases trials Research Report on Lip Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block - Cleft Lip, Cleft Palate +/- Lip | Not applicable | Not yet recruiting | Children's National Research Institute | 144 | 2026-12-16 | 2026-10-23 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-09-30 | 2026-08-13 |
| Cleft Lip and Palate Treatment Outcomes Study Cleft Lip and Palate | Not yet recruiting | University of Florida | 100 | 2026-08-01 | 2026-07-07 | |
| Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip Non-linear based phonological speech intervention, Linear-based speech intervention - Cleft Palate +/- Lip | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 12 | 2026-07-24 | 2026-07-09 |
| Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring Standard General Anesthesia per Institutional Protocol - Cleft Palate, Cleft Lip | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 150 | 2026-06-27 | 2026-06-16 | |
| MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair Modified Furlow Palatoplasty combined with buccinator myomucosal flap - Cleft Palate, Cleft Palate, Unilateral, Complete | Not applicable | Not yet recruiting | Cairo University | 10 | 2026-06-01 | 2026-04-07 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Effects of AlignBabyCleft (ABaCleft) Appliance. Orthodontic appliance to carry out dentoalveolar movement - Cleft Lip, Cleft Palate | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 30 | 2025-11-21 | 2025-04-25 |
| Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation. Early intervention for language, articulation and palatal function skills - Cleft Lip and Cleft Palate, Cleft Lip Palate | Not applicable | Not yet recruiting | Old Dominion University | 200 | 2025-10-21 | 2025-10-22 |
| Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery ketamine, Nalbuphine, Dexmedetomidine - Orofacial Clefts, Cleft Lip and Palate | Not applicable | Recruiting | University Medical Centre Ljubljana | 60 | 2025-09-01 | 2026-01-14 |
| Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate Mailing and completing CLEFT-Q and NOSE questionnaires - Cleft Lip and Cleft Palate | Recruiting | University Hospital, Montpellier | 80 | 2025-07-09 | 2025-07-22 | |
| CDH1-associated Blepharocheilodontic Syndrome Registry Blepharocheilodontic Syndrome | Recruiting | Ohio State University | 100 | 2025-06-17 | 2025-08-21 | |
| Evaluation of a Novel Nasal Conformer in Pediatric Patients use of an anatomically designed nasal conformer - Cleft Lip, Nasal Surgical Procedures | Phase 2 | Enrolling by invitation | East Tennessee Children's Hospital | 20 | 2025-06-01 | 2026-09-16 |
| Microbiome in Head and Neck Squamous Cell Carcinoma Metagenomic sequencing, Metabolic analysis - Head and Neck Cancer, Lip Cancer | Recruiting | University of Colorado, Denver | 60 | 2025-05-23 | 2026-02-24 | |
| High and Low Intensity Speech Intervention in Children With a Cleft Palate: Perceptions of Children, Their Caregivers and Speech-language Pathologists High intensive combined phonetic-phonological intervention, Low intensive combined phonetic-phonological intervention - Cleft Lip and Palate, Speech Disorders in Children | Recruiting | University Ghent | 175 | 2025-05-01 | 2025-03-26 | |
| Indications and Evaluation of Microfat Grafting in Cleft Lip Nasal Deformities Microfat grafting - Cleft Lip and Nose | Not applicable | Unknown | Assiut University | 30 | 2025-05-01 | 2024-06-18 |
| Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the Mixed Dentition Stage clear aligners - Maxillary Deficiency, Cleft Lip and Palate | Not applicable | Recruiting | Cairo University | 10 | 2025-04-06 | 2025-06-12 |
| Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy. Modified Millard rotation advancement flap technique, botulinum toxin injection (BTX A) before surgical intervention - Unilateral Cleft Lip | Not applicable | Completed | Mansoura University | 32 | 2025-03-15 | 2026-07-22 |
| Perceptions of High and Low Intensity Speech Intervention in Children With a Cleft Palate High-intensity speech therapy for children with cleft palate, Low-intensity speech therapy for children with cleft palate - Cleft Lip and Palate, Cleft Palate Children | Recruiting | University Ghent | 45 | 2025-03-01 | 2026-08-24 | |
| The Financial and Emotional Impact of Cleft Palate Questionnaires, Semi-structured interviews - Cleft Lip and Cleft Palate | Recruiting | University Hospital, Ghent | 300 | 2025-03-01 | 2025-04-01 |
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Cleft Lip (143) · Herpes Labialis (52) · Cleft Palate (44) · Lip Neoplasms (20) · Carcinoma, Squamous Cell (11) · Herpes Simplex (11) · Mouth Neoplasms (10) · Squamous Cell Carcinoma of Head and Neck (9) · Tongue Neoplasms (9) · Head and Neck Neoplasms (8) · Skin Neoplasms (8) · Oropharyngeal Neoplasms (7) · Carcinoma, Basal Cell (6) · Cicatrix (6) · Congenital Abnormalities (6)
Mouth Diseases (217) · Stomatognathic Diseases (217) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (144) · Mouth Abnormalities (143) · Stomatognathic System Abnormalities (143) · Congenital Abnormalities (137) · Skin and Connective Tissue Diseases (65) · Skin Diseases (63) · Infections (58) · DNA Virus Infections (57) · Herpesviridae Infections (56) · Virus Diseases (55) · Musculoskeletal Diseases (52) · Skin Diseases, Viral (52)
Acyclovir (6) · Alveolar Bone Grafting (4) · ME 609 (4) · Nasoalveolar Molding (4) · Orthognathic Surgery (4) · squaric acid dibutyl ester (4) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (3) · Botulinum Toxins, Type A (3) · Famciclovir (3) · Surveys and Questionnaires (3) · Ethanol (2) · Folic Acid (2) · Neurofibromin 2 (2) · Ointments (2) · Orthodontics (2)
Cairo University (22) · Alpha Tau Medical LTD. (6) · Chang Gung Memorial Hospital (6) · Faculty of Dental Medicine for Girls (5) · The University of Texas Health Science Center, Houston (5) · Assiut University (4) · Medivir (4) · NanoBio Corporation (4) · University Ghent (4) · University Hospital, Basel, Switzerland (4) · Assistance Publique - Hôpitaux de Paris (3) · GlaxoSmithKline (3) · Hospital Sirio-Libanes (3) · Squarex, LLC (3) · University Hospital, Montpellier (3)
United States (69) · Egypt (30) · France (12) · Brazil (9) · United Kingdom (8) · Germany (6) · Taiwan (6) · Belgium (5) · Israel (5) · Switzerland (5) · Turkey (Türkiye) (5) · Czechia (4) · Hong Kong (3) · Netherlands (3) · Norway (3)
Christopher M Hull, MD (2) · Jeff Murray, M.D. (2) · Quynh-Thu Le (2) · Stephen Yen, DMD, PhD (2) · Adel F Hassan, Phd (1) · Ahmed M Ali, lecturer (1) · Alexander C Allori, MD, MPH (1) · Alexandra B Kimball, MD (1) · Alicia Bucko, DO (1) · Allen Wilcox, M.D. (1) · Alper Sindel, DDS, PhD (1)
PMID 35142535, PMID 40981509, PMID 12401105, PMID 12733951, PMID 14707617, PMID 1472517, PMID 15529491, PMID 15748109, PMID 15865457, PMID 15988248, PMID 16563165, PMID 18177192, PMID 18177193, PMID 18177194, PMID 18177195, PMID 18452361, PMID 19143902, PMID 19273678, PMID 19382840, PMID 19421339, PMID 19697433, PMID 19717655, PMID 20185131, PMID 20439935, PMID 20500076, PMID 20851499, PMID 21178655, PMID 21247345, PMID 21328261, PMID 21823827, PMID 21948638, PMID 22133956, PMID 22204448, PMID 22591614, PMID 22639469, PMID 22906391, PMID 23050657, PMID 23181832, PMID 23213503, PMID 23237432, PMID 23459720, PMID 23643382, PMID 23669628, PMID 23832974, PMID 24705041, PMID 24962045, PMID 25206201, PMID 25394172, PMID 25770054, PMID 25900054
2014 (1), P30CA023074 (1), P50CA261605 (1), R01DE010437 (1), R01DE013814 (1), R01DE028554 (1), R01DE029672 (1), R21HL087819 (1), U01DE017958 (1), U01DE020057 (1), U01HD040561 (1)