319 completed, 139 recruiting, 111 unknown, 58 terminated. 194 Phase 2, 178 Not applicable, 123 Phase 1, 72 Phase 3, 32 Early Phase 1.
Follow Scleroderma, Systemic: new trials by email Literature Review of Scleroderma, Systemic trials Research Report on Scleroderma, Systemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Systemic Sclerosis (SSc) Refractory to Standard Therapy C-CAR168 - Systemic Sclerosis (SSc), Systemic Sclerosis | Phase 1 | Not yet recruiting | AbelZeta Inc. | 12 | 2027-03-01 | 2026-10-13 |
| A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis BMS-986353, Fludarabine, Cyclophosphamide - Systemic Sclerosis | Phase 3 | Not yet recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 92 | 2027-02-03 | 2026-09-18 |
| Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune Diseases HN2302 Injection - Autoimmune Disease, Systemic Lupus Erythematosus | Phase 1 | Not yet recruiting | Shenzhen MagicRNA Biotechnology Co., Ltd | 12 | 2026-12-31 | 2026-08-12 |
| Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases anti-CD19 CAR-T cells - Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) | Phase 1 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 6 | 2026-12-01 | 2026-09-02 |
| Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies biological samples - Systememic Lupus Erythematosus, Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 120 | 2026-12-01 | 2026-09-24 |
| Mycophenolate After Stem Cell Transplant for Systemic Sclerosis Mycophenolate Mofetil 1000 mg twice daily - Systemic Sclerosis (SSc) | Phase 2 | Not yet recruiting | Ottawa Hospital Research Institute | 6 | 2026-12-01 | 2026-10-19 |
| A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases PF-08154225 - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 / Phase 2 | Not yet recruiting | Pfizer | 54 | 2026-11-19 | 2026-10-01 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| Catestatin as a Novel Biomarker for Cardiovascular and Microvascular Involvement in Systemic Sclerosis Systemic Sclerosis | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2025-10-07 | |
| Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial Hyaluronidase (Hylenex) - Systemic Sclerosis, Sclerodactyly | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 10 | 2026-11-01 | 2026-10-16 |
| Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis Hyperpolarized 129 Xenon Gas - Interstitial Lung Disease, Pulmonary Hypertension | Phase 2 | Not yet recruiting | Bastiaan Driehuys | 51 | 2026-11-01 | 2026-09-15 |
| Obinutuzumab in Systemic Sclerosis Obinutuzumab, Placebo - Systemic Sclerosis in Adults | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2026-11-01 | 2026-09-25 |
| Using AI-Assisted Cameras to Track Hand Exercises in Scleroderma Patients AI-powered, camera-based, exercise-focused telerehabilitation, Physiotherapist-supervised, exercise-focused rehabilitation - Systemic Scleroderma | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 40 | 2026-11-01 | 2026-10-14 |
| A Clinical Study on Systemic Sclerosis and the Validation of French-language Questionnaires Assessing Disability, Quality of Life, and Disease Status. Questionnaires - Scleroderma | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 200 | 2026-11-01 | 2026-10-22 | |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs) Blood Sample Collection - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University Hospital, Montpellier | 16 | 2026-10-27 | 2026-10-29 |
| A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have Symptomatic Raynaud's Phenomenon Attacks LIQ861 (treprostinil) inhalation powder - Dose Titration Arm, LIQ861 (treprostinil) inhalation powder - fixed dose arm - Raynaud's Phenomenon Secondary to Systemic Sclerosis | Phase 2 | Not yet recruiting | Liquidia Technologies, Inc. | 75 | 2026-10-26 | 2026-08-07 |
| Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis Home-based exercise programme, Usual Care - Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | University of Aarhus | 270 | 2026-10-15 | 2026-09-25 |
| Combined Growth Differentiation Factor-15 (GDF-15) and Lung Ultrasound for ILD Screening in Rheumatoid Arthritis and Systemic Sclerosis Lung ultrasound, GDF-15 level (ELISA), CT scan - Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc) | Not yet recruiting | Assiut University | 110 | 2026-10-15 | 2026-09-25 | |
| Nebulized UC-EVs for Recurrent or Refractory IMIDs With Lung Involvement nebulized human umbilical cord mesenchymal stromal cell-derived extracellular vesicles - IgG4 Related Disease, Systemic Sclerosis (SSc) | Early Phase 1 | Not yet recruiting | Qiubai Li | 18 | 2026-10-14 | 2026-09-08 |
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Scleroderma, Diffuse (307) · Lupus Erythematosus, Systemic (114) · Myositis (73) · Arthritis, Rheumatoid (72) · Autoimmune Diseases (65) · Sjogren's Syndrome (58) · Lung Diseases, Interstitial (51) · Raynaud Disease (43) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (42) · Dermatomyositis (35) · Hypertension, Pulmonary (32) · Connective Tissue Diseases (31) · digital ulcers (25) · Antiphospholipid Syndrome (21)
Skin and Connective Tissue Diseases (753) · Skin Diseases (744) · Connective Tissue Diseases (722) · Immune System Diseases (186) · Musculoskeletal Diseases (156) · Cardiovascular Diseases (146) · Vascular Diseases (141) · Autoimmune Diseases (121) · Joint Diseases (119) · Nervous System Diseases (118) · Respiratory Tract Diseases (117) · Lung Diseases (108) · Arthritis (106) · Neuromuscular Diseases (106)
Cyclophosphamide (32) · Blood Specimen Collection (21) · Mycophenolic Acid (19) · fludarabine (18) · Bosentan (12) · Rituximab (12) · Imatinib Mesylate (8) · tocilizumab (7) · Methotrexate (6) · Nitroglycerin (6) · Sildenafil Citrate (6) · Surveys and Questionnaires (6) · fludarabine phosphate (6) · treprostinil (6) · Hematologic Tests (5)
Assistance Publique - Hôpitaux de Paris (24) · University of Michigan (20) · University Hospital, Lille (14) · Assiut University (13) · Actelion (11) · University Hospital, Strasbourg, France (11) · Johns Hopkins University (10) · Lady Davis Institute (9) · Duke University (8) · Assistance Publique Hopitaux De Marseille (7) · Istanbul University (7) · University Hospital, Bordeaux (7) · Hacettepe University (6) · Khon Kaen University (6) · MediQuest Therapeutics (6)
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