169 completed, 40 unknown, 20 recruiting, 15 terminated. 108 Not applicable, 51 Phase 3, 25 Phase 4, 23 Phase 2, 6 Phase 1.
Follow Otitis Media: new trials by email Literature Review of Otitis Media trials Research Report on Otitis Media
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EarFlo: A Non-Invasive Treatment for Otitis Media With Effusion & Eustachian Tube Dysfunction in Adults EarFlo Device - Otitis Media With Effusion (OME), Eustachian Tube Dysfunction | Not applicable | Not yet recruiting | Philip Perez | 100 | 2026-11-20 | 2026-11-10 |
| Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children Amoxicillin, Amoxicillin + Clavulanate, Placebo - Acute Otitis Media, AOM - Acute Otitis Media | Phase 4 | Not yet recruiting | Kuopio University Hospital | 219 | 2026-11-01 | 2026-10-16 |
| Short-term Application of Lactoferrin Ventilation Tubes Ventilation tube insertion - Otitis Media With Effusion (OME) | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 20 | 2026-10-25 | 2026-11-03 |
| Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results? Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty - Tympanic Membrane Perforation, Otitis Media | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-10-01 | 2026-09-22 |
| Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media) Amoxicillin, Amoxicillin-Clavulanate, Amoxicillin Placebo - Acute Otitis Media (AOM) | Phase 4 | Recruiting | Nader Shaikh | 1100 | 2026-10-01 | 2026-10-20 |
| Towards Implementation of Universal Newborn Hearing Screening in Kenya Hearing and ear health screening - Hearing Loss, Bilateral or Unilateral, Otitis Media With Effusion in Children | Not applicable | Recruiting | University of Washington | 400 | 2026-09-24 | 2026-10-16 |
| Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care Center Tonsillitis Acute, Pneumonia - Bacterial | Not yet recruiting | University Hospital, Montpellier | 191 | 2026-09-01 | 2026-07-17 | |
| Parent-led Assessment and Recognition of AOM Using Digital Ear Imaging Assigning of a digital otoscope to the families in the intervention group - Acute Otitis Media, Otitis Media | Not applicable | Recruiting | Turku University Hospital | 40 | 2026-09-01 | 2026-09-08 |
| Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis Media Experimental Osteopathic Manipulative Treatment (OMT) Protocol, Control Osteopathic Manipulative Treatment (OMT) Protocol - Otitis Media, Otitis Media Effusion | Not applicable | Not yet recruiting | Sarah Vidal | 200 | 2026-08-01 | 2026-06-10 |
| The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health 'Standard of Care PLUS' - Preterm Birth, Preeclampsia | Not applicable | Not yet recruiting | GrowBaby Life Project | 500 | 2026-08-01 | 2026-04-30 |
| CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes CLiKX® Tympanostomy Tube Delivery System - Otitis Media, Otitis Media Chronic | Not applicable | Recruiting | ClinQure, Inc. | 80 | 2026-07-07 | 2026-11-03 |
| Post-Market Clinical Follow-Up Study of the Solo+ Tympanostomy Tube Device Solo+ Tympanostomy Tube Device (Solo+ TTD) - Otitis Media, Middle Ear Infections | Recruiting | AventaMed DAC | 160 | 2026-05-21 | 2026-08-13 | |
| SWIR Otoscopy Study SWIR device - Otitis Media, Otitis Media Chronic | Not applicable | Recruiting | Stanford University | 100 | 2026-04-30 | 2026-07-24 |
| Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young Children Device: Digital Otoscope - Otitis Media, Antimicrobial Stewardship | Not applicable | Active not recruiting | Boston Children's Hospital | 36 | 2026-03-01 | 2026-05-22 |
| Evaluating Laser Otoscope for Middle Ear Effusion Detection Laser otoscope examination - Middle Ear Effusion, Otitis Media | Not yet recruiting | MSTATT LLC | 150 | 2026-03-01 | 2026-03-06 | |
| Validating and AI Software for Assessment of Children With Ear Concerns Otalgia, Otitis Media | Not yet recruiting | Glimpse Diagnostics, Inc. | 658 | 2026-01-01 | 2025-11-21 | |
| Laser Acupuncture for Otitis Media With Effusion in Children Laser Acupuncture, Sham Laser Acupuncture - Otitis Media With Effusion | Not applicable | Completed | Universitas Indonesia | 32 | 2025-12-29 | 2026-06-04 |
| Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds Standard Clinical Ear Exam, AI app ear exam and diagnosis - Acute Otitis Media (AOM), Upper Respiratory Infection | Not applicable | Recruiting | Timothy Shope | 300 | 2025-12-04 | 2026-10-08 |
| Gamified Training and AI Support for Improving Ear Infection Diagnosis in Primary Care AOM Dx Trainer (gamified educational program), No Intervention - Standard Care - Otitis Media Acute, Otitis Media Effusion | Not applicable | Not yet recruiting | Vastra Gotaland Region | 200 | 2025-12-01 | 2025-11-24 |
| Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care Antibiotic prescribing according to guidelines - Angina, Acute Bronchiolitis | Not applicable | Recruiting | University Hospital, Caen | 4500 | 2025-12-01 | 2026-01-22 |
Showing 20 of 277. Sign in to see all of them.
Otitis Media with Effusion (81) · Otitis (40) · Respiratory Tract Infections (13) · Pneumonia (12) · Hearing Loss (10) · Hearing Loss, Conductive (8) · Pharyngitis (8) · Tympanic Membrane Perforation (8) · Otitis Media, Suppurative (7) · Streptococcal Infections (7) · Pain (6) · Pneumococcal Infections (6) · Community-Acquired Pneumonia (5) · Mastoiditis (5)
Ear Diseases (277) · Otorhinolaryngologic Diseases (277) · Otitis (237) · Infections (57) · Pathological Conditions, Signs and Symptoms (42) · Respiratory Tract Diseases (40) · Signs and Symptoms (32) · Nervous System Diseases (25) · Neurologic Manifestations (25) · Respiratory Tract Infections (24) · Lung Diseases (20) · Bacterial Infections and Mycoses (17) · Stomatognathic Diseases (17) · Bacterial Infections (16)
Amoxicillin-Potassium Clavulanate Combination (13) · Middle Ear Ventilation (11) · Amoxicillin (8) · Adenoidectomy (7) · Ciprofloxacin (6) · Azithromycin (4) · Benzocaine (4) · PHiD-CV vaccine (4) · 13-valent pneumococcal vaccine (3) · Cefdinir (3) · Data Collection (3) · Dexamethasone (3) · Educational Status (3) · Hepatitis A Vaccines (3) · Hepatitis B Vaccines (3)
GlaxoSmithKline (11) · Integra LifeSciences Corporation (9) · University of Pittsburgh (8) · Alcon Research (7) · Pfizer (7) · Boston Children's Hospital (5) · Children's Hospital of Philadelphia (5) · Menzies School of Health Research (5) · Otonomy, Inc. (5) · AventaMed DAC (4) · National Institute on Deafness and Other Communication Disorders (NIDCD) (4) · University of Washington (4) · Abbott (3) · Arbor Pharmaceuticals, Inc. (3) · Assiut University (3)
United States (113) · Canada (13) · Finland (12) · Israel (12) · Australia (8) · France (8) · Costa Rica (7) · Belgium (6) · Italy (6) · Panama (6) · Turkey (Türkiye) (6) · Sweden (5) · Argentina (4) · Chile (4) · Czechia (4)
Amanda J Leach, PhD (4) · Carl LeBel, PhD (4) · Cuneyt M Alper, MD (4) · Matija Daniel (4) · Alejandro Hoberman, MD (3) · Louis Vernacchio, MD, MSc (3) · Aino Ruohola, MD, PhD (2) · Edward K Mulholland, DM (2) · Hao Xiong (2) · Hasse Ejnell (2)
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P50DC007667 (3), 2008 (2), 2025 (2), 2014 (1), 2015 (1), 2023 (1), P50AT000008 (1), R01DC002620 (1), R01DC005630 (1), R01DC011524 (1), R01DC019412 (1), R01DC021326 (1), R21DC013167 (1), R21DC017553 (1), R33DC021643 (1)